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Variation in the amount of petrolatum preparation applied at patch testing.

Bruze, Magnus LU ; Frick-Engfeldt, Malin; Gruvberger, Birgitta LU and Isaksson, Marléne LU (2007) In Contact Dermatitis 56(1). p.38-42
Abstract
The elicitation of a positive patch test reaction in a given individual depends upon the dose of the sensitizer applied, the patch test technique and the occlusion time. The dose is determined by the concentration and volume/amount of test preparation applied. If the same amount/volume of a test preparation is applied all the time with the same test technique (same area of skin) and occlusion time, it is appropriate to use concentration as a dose parameter. Most contact sensitizers are incorporated in petrolatum (pet.). With pet. as vehicle, it is impossible to repeatedly apply an exact volume/amount. This study was performed to investigate the inter- and intra-individual variation of pet. preparation applied at patch testing by 3... (More)
The elicitation of a positive patch test reaction in a given individual depends upon the dose of the sensitizer applied, the patch test technique and the occlusion time. The dose is determined by the concentration and volume/amount of test preparation applied. If the same amount/volume of a test preparation is applied all the time with the same test technique (same area of skin) and occlusion time, it is appropriate to use concentration as a dose parameter. Most contact sensitizers are incorporated in petrolatum (pet.). With pet. as vehicle, it is impossible to repeatedly apply an exact volume/amount. This study was performed to investigate the inter- and intra-individual variation of pet. preparation applied at patch testing by 3 technicians. Weighing demonstrated that the 3 technicians had about the same precision in their pet. application. The investigation demonstrates that there is both an inter-individual (statistically significant) and intra-individual variation in the amounts of pet. applied at patch testing for the 3 technicians. Presently, there is no recommendation on what amount of pet. preparation to apply, which merits a decision to be taken based on thorough investigations on the appropriate volumes of pet. preparation to be applied in various patch test systems. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
weighing, standard series, intra-individual, inter-individual, (R), Finn Chamber, dose/area, allergic contact dermatitis, contact allergy
in
Contact Dermatitis
volume
56
issue
1
pages
38 - 42
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000242658800008
  • scopus:33845520814
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2007.00985.x
language
English
LU publication?
yes
id
3a49df0a-676d-4d93-a1c6-8cf897677952 (old id 163910)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17177708&dopt=Abstract
date added to LUP
2007-07-16 14:41:56
date last changed
2017-08-27 04:08:53
@article{3a49df0a-676d-4d93-a1c6-8cf897677952,
  abstract     = {The elicitation of a positive patch test reaction in a given individual depends upon the dose of the sensitizer applied, the patch test technique and the occlusion time. The dose is determined by the concentration and volume/amount of test preparation applied. If the same amount/volume of a test preparation is applied all the time with the same test technique (same area of skin) and occlusion time, it is appropriate to use concentration as a dose parameter. Most contact sensitizers are incorporated in petrolatum (pet.). With pet. as vehicle, it is impossible to repeatedly apply an exact volume/amount. This study was performed to investigate the inter- and intra-individual variation of pet. preparation applied at patch testing by 3 technicians. Weighing demonstrated that the 3 technicians had about the same precision in their pet. application. The investigation demonstrates that there is both an inter-individual (statistically significant) and intra-individual variation in the amounts of pet. applied at patch testing for the 3 technicians. Presently, there is no recommendation on what amount of pet. preparation to apply, which merits a decision to be taken based on thorough investigations on the appropriate volumes of pet. preparation to be applied in various patch test systems.},
  author       = {Bruze, Magnus and Frick-Engfeldt, Malin and Gruvberger, Birgitta and Isaksson, Marléne},
  issn         = {0105-1873},
  keyword      = {weighing,standard series,intra-individual,inter-individual,(R),Finn Chamber,dose/area,allergic contact dermatitis,contact allergy},
  language     = {eng},
  number       = {1},
  pages        = {38--42},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Variation in the amount of petrolatum preparation applied at patch testing.},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2007.00985.x},
  volume       = {56},
  year         = {2007},
}