Advanced

Calpain activity in retinal degeneration.

Paquet-Durand, Francois LU ; Johnson, Leif LU and Ekström, Per LU (2007) In Journal of Neuroscience Research 85(4). p.693-702
Abstract
Retinal degenerations such as retinitis pigmentosa (RP) or glaucoma are a major cause of blindness in humans. Understanding the mechanisms underlying the various types of retinal degeneration is a pre-requisite for the development of rational therapies for these diseases. Activation of the calcium dependent protease, calpain, has been suggested to play an important role in cell death in various neuronal tissues including the retina. Improved detection and analysis of calpain activity during degenerative processes is likely to expand the list of pathological conditions with calpain involvement. We give a short overview of the methods available for the detection of calpain activity, and briefly discuss properties of calpain inhibitors. We... (More)
Retinal degenerations such as retinitis pigmentosa (RP) or glaucoma are a major cause of blindness in humans. Understanding the mechanisms underlying the various types of retinal degeneration is a pre-requisite for the development of rational therapies for these diseases. Activation of the calcium dependent protease, calpain, has been suggested to play an important role in cell death in various neuronal tissues including the retina. Improved detection and analysis of calpain activity during degenerative processes is likely to expand the list of pathological conditions with calpain involvement. We give a short overview of the methods available for the detection of calpain activity, and briefly discuss properties of calpain inhibitors. We then discuss the role of calpains in different cell death mechanisms and review existing work on retinal degeneration and the possible involvement of calpains therein. The implication of calpains in retinal cell death raises the possibility to use calpain inhibitors to prevent or delay retinal degeneration. (c) 2006 Wiley-Liss, Inc. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
photoreceptor, cell death, calcium, retinitis pigmentosa, calpastatin
in
Journal of Neuroscience Research
volume
85
issue
4
pages
693 - 702
publisher
John Wiley & Sons
external identifiers
  • wos:000245158800001
  • scopus:33947221587
ISSN
1097-4547
DOI
10.1002/jnr.21151
language
English
LU publication?
yes
id
e8798989-811b-4eb4-824f-882e762440ae (old id 163978)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17171699&dopt=Abstract
date added to LUP
2007-07-16 15:47:26
date last changed
2017-01-25 16:21:33
@article{e8798989-811b-4eb4-824f-882e762440ae,
  abstract     = {Retinal degenerations such as retinitis pigmentosa (RP) or glaucoma are a major cause of blindness in humans. Understanding the mechanisms underlying the various types of retinal degeneration is a pre-requisite for the development of rational therapies for these diseases. Activation of the calcium dependent protease, calpain, has been suggested to play an important role in cell death in various neuronal tissues including the retina. Improved detection and analysis of calpain activity during degenerative processes is likely to expand the list of pathological conditions with calpain involvement. We give a short overview of the methods available for the detection of calpain activity, and briefly discuss properties of calpain inhibitors. We then discuss the role of calpains in different cell death mechanisms and review existing work on retinal degeneration and the possible involvement of calpains therein. The implication of calpains in retinal cell death raises the possibility to use calpain inhibitors to prevent or delay retinal degeneration. (c) 2006 Wiley-Liss, Inc.},
  author       = {Paquet-Durand, Francois and Johnson, Leif and Ekström, Per},
  issn         = {1097-4547},
  keyword      = {photoreceptor,cell death,calcium,retinitis pigmentosa,calpastatin},
  language     = {eng},
  number       = {4},
  pages        = {693--702},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Neuroscience Research},
  title        = {Calpain activity in retinal degeneration.},
  url          = {http://dx.doi.org/10.1002/jnr.21151},
  volume       = {85},
  year         = {2007},
}