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Are there differences of inflammatory bio-markers between diabetic and non-diabetic patients with critical limb ischemia?

Bertz, L ; Barani, Jamal LU ; Gottsäter, Anders LU ; Nilsson, P M ; Mattiasson, Ingrid LU and Lindblad, Bengt LU (2006) In International Angiology 25(4). p.370-377
Abstract
Aim. This observational study was undertaken in order to analyse whether any differences could be detected between diabetic and non-diabetic patients with critical limb ischemia (CLI) concerning the inflammatory response. Methods. A total number of 259 consecutive patients with CLI were treated between October 2001 and January 2003. Results. Among the 259 patients, 135 (52%) had diabetes, previously known in 123, and detected during hospitalization in 12. The diabetic patients more often showed gangrene (P < 0.05) and infra-inguinal atherosclerosis (84% vs 67%, P=0.001). The patients with diabetes showed a better lipid profile (total cholesterol 4.6 vs 5 mmol/L, P=0.006 and lower LDL-cholesterol (2.7 vs 3.1 mmol/L, P=0.010) despite the... (More)
Aim. This observational study was undertaken in order to analyse whether any differences could be detected between diabetic and non-diabetic patients with critical limb ischemia (CLI) concerning the inflammatory response. Methods. A total number of 259 consecutive patients with CLI were treated between October 2001 and January 2003. Results. Among the 259 patients, 135 (52%) had diabetes, previously known in 123, and detected during hospitalization in 12. The diabetic patients more often showed gangrene (P < 0.05) and infra-inguinal atherosclerosis (84% vs 67%, P=0.001). The patients with diabetes showed a better lipid profile (total cholesterol 4.6 vs 5 mmol/L, P=0.006 and lower LDL-cholesterol (2.7 vs 3.1 mmol/L, P=0.010) despite the same frequency of statin treatment. They showed a higher creatinine (149 vs 117 pmol/L, P=0.0003) than the nondiabetic patients. Of the inflammatory markers, C-reactive protein (CRP) was equally elevated in both groups. Tumor necrosis factor-a (TNF-a) was increased among the diabetic patients (2.6 vs 1.8 pg/mL, P < 0.05), and this difference was most evident in those with gangrene. Neopterin was also higher among the diabetic patients (31 vs 21 mmol/L, P < 0.01), but CD40L was not different between groups. Conclusions. Diabetes mellitus was very common in CLI patients, and more often combined with renal impairment and infra-inguinal atherosclerosis. The inflammatory markers TNF-alpha and neopterin were elevated in patients with diabetes as compared to non-diabetic patients, but this difference cannot explain why CLI is 10 times more frequent in diabetic patients. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
limb ischemia, diabetes mellitus, inflammatory markers, neopterin, tumor necrosis factor alfa, CD40L
in
International Angiology
volume
25
issue
4
pages
370 - 377
publisher
Minerva Medica
external identifiers
  • wos:000244592700006
  • scopus:33847673520
ISSN
1827-1839
language
English
LU publication?
yes
id
a2b249a5-c2ea-43b0-ad68-d94f967e0809 (old id 164032)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17164743&dopt=Abstract
date added to LUP
2016-04-01 11:50:56
date last changed
2021-08-18 01:15:53
@article{a2b249a5-c2ea-43b0-ad68-d94f967e0809,
  abstract     = {Aim. This observational study was undertaken in order to analyse whether any differences could be detected between diabetic and non-diabetic patients with critical limb ischemia (CLI) concerning the inflammatory response. Methods. A total number of 259 consecutive patients with CLI were treated between October 2001 and January 2003. Results. Among the 259 patients, 135 (52%) had diabetes, previously known in 123, and detected during hospitalization in 12. The diabetic patients more often showed gangrene (P &lt; 0.05) and infra-inguinal atherosclerosis (84% vs 67%, P=0.001). The patients with diabetes showed a better lipid profile (total cholesterol 4.6 vs 5 mmol/L, P=0.006 and lower LDL-cholesterol (2.7 vs 3.1 mmol/L, P=0.010) despite the same frequency of statin treatment. They showed a higher creatinine (149 vs 117 pmol/L, P=0.0003) than the nondiabetic patients. Of the inflammatory markers, C-reactive protein (CRP) was equally elevated in both groups. Tumor necrosis factor-a (TNF-a) was increased among the diabetic patients (2.6 vs 1.8 pg/mL, P &lt; 0.05), and this difference was most evident in those with gangrene. Neopterin was also higher among the diabetic patients (31 vs 21 mmol/L, P &lt; 0.01), but CD40L was not different between groups. Conclusions. Diabetes mellitus was very common in CLI patients, and more often combined with renal impairment and infra-inguinal atherosclerosis. The inflammatory markers TNF-alpha and neopterin were elevated in patients with diabetes as compared to non-diabetic patients, but this difference cannot explain why CLI is 10 times more frequent in diabetic patients.},
  author       = {Bertz, L and Barani, Jamal and Gottsäter, Anders and Nilsson, P M and Mattiasson, Ingrid and Lindblad, Bengt},
  issn         = {1827-1839},
  language     = {eng},
  number       = {4},
  pages        = {370--377},
  publisher    = {Minerva Medica},
  series       = {International Angiology},
  title        = {Are there differences of inflammatory bio-markers between diabetic and non-diabetic patients with critical limb ischemia?},
  url          = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17164743&dopt=Abstract},
  volume       = {25},
  year         = {2006},
}