Are there differences of inflammatory bio-markers between diabetic and non-diabetic patients with critical limb ischemia?
(2006) In International Angiology 25(4). p.370-377- Abstract
- Aim. This observational study was undertaken in order to analyse whether any differences could be detected between diabetic and non-diabetic patients with critical limb ischemia (CLI) concerning the inflammatory response. Methods. A total number of 259 consecutive patients with CLI were treated between October 2001 and January 2003. Results. Among the 259 patients, 135 (52%) had diabetes, previously known in 123, and detected during hospitalization in 12. The diabetic patients more often showed gangrene (P < 0.05) and infra-inguinal atherosclerosis (84% vs 67%, P=0.001). The patients with diabetes showed a better lipid profile (total cholesterol 4.6 vs 5 mmol/L, P=0.006 and lower LDL-cholesterol (2.7 vs 3.1 mmol/L, P=0.010) despite the... (More)
- Aim. This observational study was undertaken in order to analyse whether any differences could be detected between diabetic and non-diabetic patients with critical limb ischemia (CLI) concerning the inflammatory response. Methods. A total number of 259 consecutive patients with CLI were treated between October 2001 and January 2003. Results. Among the 259 patients, 135 (52%) had diabetes, previously known in 123, and detected during hospitalization in 12. The diabetic patients more often showed gangrene (P < 0.05) and infra-inguinal atherosclerosis (84% vs 67%, P=0.001). The patients with diabetes showed a better lipid profile (total cholesterol 4.6 vs 5 mmol/L, P=0.006 and lower LDL-cholesterol (2.7 vs 3.1 mmol/L, P=0.010) despite the same frequency of statin treatment. They showed a higher creatinine (149 vs 117 pmol/L, P=0.0003) than the nondiabetic patients. Of the inflammatory markers, C-reactive protein (CRP) was equally elevated in both groups. Tumor necrosis factor-a (TNF-a) was increased among the diabetic patients (2.6 vs 1.8 pg/mL, P < 0.05), and this difference was most evident in those with gangrene. Neopterin was also higher among the diabetic patients (31 vs 21 mmol/L, P < 0.01), but CD40L was not different between groups. Conclusions. Diabetes mellitus was very common in CLI patients, and more often combined with renal impairment and infra-inguinal atherosclerosis. The inflammatory markers TNF-alpha and neopterin were elevated in patients with diabetes as compared to non-diabetic patients, but this difference cannot explain why CLI is 10 times more frequent in diabetic patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/164032
- author
- Bertz, L ; Barani, Jamal LU ; Gottsäter, Anders LU ; Nilsson, P M ; Mattiasson, Ingrid LU and Lindblad, Bengt LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- keywords
- limb ischemia, diabetes mellitus, inflammatory markers, neopterin, tumor necrosis factor alfa, CD40L
- in
- International Angiology
- volume
- 25
- issue
- 4
- pages
- 370 - 377
- publisher
- Minerva Medica
- external identifiers
-
- wos:000244592700006
- scopus:33847673520
- ISSN
- 1827-1839
- language
- English
- LU publication?
- yes
- id
- a2b249a5-c2ea-43b0-ad68-d94f967e0809 (old id 164032)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17164743&dopt=Abstract
- date added to LUP
- 2016-04-01 11:50:56
- date last changed
- 2025-04-03 18:20:10
@article{a2b249a5-c2ea-43b0-ad68-d94f967e0809,
abstract = {{Aim. This observational study was undertaken in order to analyse whether any differences could be detected between diabetic and non-diabetic patients with critical limb ischemia (CLI) concerning the inflammatory response. Methods. A total number of 259 consecutive patients with CLI were treated between October 2001 and January 2003. Results. Among the 259 patients, 135 (52%) had diabetes, previously known in 123, and detected during hospitalization in 12. The diabetic patients more often showed gangrene (P < 0.05) and infra-inguinal atherosclerosis (84% vs 67%, P=0.001). The patients with diabetes showed a better lipid profile (total cholesterol 4.6 vs 5 mmol/L, P=0.006 and lower LDL-cholesterol (2.7 vs 3.1 mmol/L, P=0.010) despite the same frequency of statin treatment. They showed a higher creatinine (149 vs 117 pmol/L, P=0.0003) than the nondiabetic patients. Of the inflammatory markers, C-reactive protein (CRP) was equally elevated in both groups. Tumor necrosis factor-a (TNF-a) was increased among the diabetic patients (2.6 vs 1.8 pg/mL, P < 0.05), and this difference was most evident in those with gangrene. Neopterin was also higher among the diabetic patients (31 vs 21 mmol/L, P < 0.01), but CD40L was not different between groups. Conclusions. Diabetes mellitus was very common in CLI patients, and more often combined with renal impairment and infra-inguinal atherosclerosis. The inflammatory markers TNF-alpha and neopterin were elevated in patients with diabetes as compared to non-diabetic patients, but this difference cannot explain why CLI is 10 times more frequent in diabetic patients.}},
author = {{Bertz, L and Barani, Jamal and Gottsäter, Anders and Nilsson, P M and Mattiasson, Ingrid and Lindblad, Bengt}},
issn = {{1827-1839}},
keywords = {{limb ischemia; diabetes mellitus; inflammatory markers; neopterin; tumor necrosis factor alfa; CD40L}},
language = {{eng}},
number = {{4}},
pages = {{370--377}},
publisher = {{Minerva Medica}},
series = {{International Angiology}},
title = {{Are there differences of inflammatory bio-markers between diabetic and non-diabetic patients with critical limb ischemia?}},
url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17164743&dopt=Abstract}},
volume = {{25}},
year = {{2006}},
}