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Anti-androgenic treatment of obsessive-compulsive disorder: an open-label clinical trial of the long-acting gonadotropin-releasing hormone analogue triptorelin.

Eriksson, Tomas LU (2007) In International Clinical Psychopharmacology 22(1). p.57-61
Abstract
Some case reports have shown that patients suffering from obsessive-compulsive disorder can be effectively treated with anti-androgenic pharmacological agents with various modes of action. The most effective group of such agents is the long-acting analogues of the gonadotropin-releasing hormone. This investigation was undertaken in order to further elucidate the possibility of using such powerful anti-androgenic agents in the treatment of obsessive-compulsive disorder. Six male patients, all suffering from therapy-resistant obsessive-compulsive disorder, were included in a 48 weeks open-label trial of the long-acting GnRH-analogue triptorelin. Every other week, the patients rated the severity of obsessive-compulsive disorder symptoms by... (More)
Some case reports have shown that patients suffering from obsessive-compulsive disorder can be effectively treated with anti-androgenic pharmacological agents with various modes of action. The most effective group of such agents is the long-acting analogues of the gonadotropin-releasing hormone. This investigation was undertaken in order to further elucidate the possibility of using such powerful anti-androgenic agents in the treatment of obsessive-compulsive disorder. Six male patients, all suffering from therapy-resistant obsessive-compulsive disorder, were included in a 48 weeks open-label trial of the long-acting GnRH-analogue triptorelin. Every other week, the patients rated the severity of obsessive-compulsive disorder symptoms by means of a visual analogue scale. During the course of the trial, five out of six patients experienced a considerable improvement. The finding gives further support to the contention that anti-androgenic agents are effective in the treatment of obsessive-compulsive disorder. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
clinical trial, anti-androgens, gonadotropin-releasing hormone, obsessive-compulsive disorder, treatment, triptorelin
in
International Clinical Psychopharmacology
volume
22
issue
1
pages
57 - 61
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000243146000008
  • scopus:33845652185
ISSN
1473-5857
DOI
10.1097/01.yic.0000224793.51900.cb
language
English
LU publication?
yes
id
28e2cb9d-2b63-4b43-91ca-4b32fc03741f (old id 164076)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17159461&dopt=Abstract
date added to LUP
2007-07-18 16:36:22
date last changed
2017-01-01 05:00:20
@article{28e2cb9d-2b63-4b43-91ca-4b32fc03741f,
  abstract     = {Some case reports have shown that patients suffering from obsessive-compulsive disorder can be effectively treated with anti-androgenic pharmacological agents with various modes of action. The most effective group of such agents is the long-acting analogues of the gonadotropin-releasing hormone. This investigation was undertaken in order to further elucidate the possibility of using such powerful anti-androgenic agents in the treatment of obsessive-compulsive disorder. Six male patients, all suffering from therapy-resistant obsessive-compulsive disorder, were included in a 48 weeks open-label trial of the long-acting GnRH-analogue triptorelin. Every other week, the patients rated the severity of obsessive-compulsive disorder symptoms by means of a visual analogue scale. During the course of the trial, five out of six patients experienced a considerable improvement. The finding gives further support to the contention that anti-androgenic agents are effective in the treatment of obsessive-compulsive disorder.},
  author       = {Eriksson, Tomas},
  issn         = {1473-5857},
  keyword      = {clinical trial,anti-androgens,gonadotropin-releasing hormone,obsessive-compulsive disorder,treatment,triptorelin},
  language     = {eng},
  number       = {1},
  pages        = {57--61},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {International Clinical Psychopharmacology},
  title        = {Anti-androgenic treatment of obsessive-compulsive disorder: an open-label clinical trial of the long-acting gonadotropin-releasing hormone analogue triptorelin.},
  url          = {http://dx.doi.org/10.1097/01.yic.0000224793.51900.cb},
  volume       = {22},
  year         = {2007},
}