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The challenge of managing patients with polyarteritis nodosa.

Segelmark, Mårten LU and Selga, Daina LU (2007) In Current Opinion in Rheumatology 19(1). p.33-38
Abstract
Purpose of review In this short review we focus on the problems faced by clinicians caused by the changing definitions of polyarteritis nodosa. Recent findings the term polyarteritis nodosa has been used for more than 100 years as a diagnostic term for patients with systemic vasculitis, however, specific vasculitides have been singled out like branches being chopped off a tree. Now, so little is left of the trunk of that tree that it is questionable to what extent we can trust older literature with respect to clinical features, natural history and response to treatment. Many authors of case reports, as well as authors of reviews and book chapters, claim they adhere to the Chapel Hill Consensus Conference definition of polyartentis nodosa... (More)
Purpose of review In this short review we focus on the problems faced by clinicians caused by the changing definitions of polyarteritis nodosa. Recent findings the term polyarteritis nodosa has been used for more than 100 years as a diagnostic term for patients with systemic vasculitis, however, specific vasculitides have been singled out like branches being chopped off a tree. Now, so little is left of the trunk of that tree that it is questionable to what extent we can trust older literature with respect to clinical features, natural history and response to treatment. Many authors of case reports, as well as authors of reviews and book chapters, claim they adhere to the Chapel Hill Consensus Conference definition of polyartentis nodosa yet still cite almost exclusively studies using older definitions without highlighting this dilemma. In the past year, two proposals affecting classification have been published: one stating that cutaneous polyarteritis nodosa and hepatitis associated polyarteritis nodosa, and one providing an algorithm to separate microscopic polyangiitis from classical polyarteritis nodosa. Summary There is hope that a wide acceptance of the new classification principles will lead to a more uniform way to diagnose classical polyarteritis nodosa, which will facilitate clinical studies and eventually improve management. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
nodosa, polyarteritis, hepatitis, clssification, microscopic polyangiitis, vasculitis
in
Current Opinion in Rheumatology
volume
19
issue
1
pages
33 - 38
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000243632300005
  • scopus:33845372641
ISSN
1531-6963
DOI
10.1097/BOR.0b013e328011cb6f
language
English
LU publication?
yes
id
e4dd3615-dc6c-4248-a13c-8888ffcc8f21 (old id 164194)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17143093&dopt=Abstract
date added to LUP
2007-07-10 13:42:06
date last changed
2017-08-06 03:36:18
@article{e4dd3615-dc6c-4248-a13c-8888ffcc8f21,
  abstract     = {Purpose of review In this short review we focus on the problems faced by clinicians caused by the changing definitions of polyarteritis nodosa. Recent findings the term polyarteritis nodosa has been used for more than 100 years as a diagnostic term for patients with systemic vasculitis, however, specific vasculitides have been singled out like branches being chopped off a tree. Now, so little is left of the trunk of that tree that it is questionable to what extent we can trust older literature with respect to clinical features, natural history and response to treatment. Many authors of case reports, as well as authors of reviews and book chapters, claim they adhere to the Chapel Hill Consensus Conference definition of polyartentis nodosa yet still cite almost exclusively studies using older definitions without highlighting this dilemma. In the past year, two proposals affecting classification have been published: one stating that cutaneous polyarteritis nodosa and hepatitis associated polyarteritis nodosa, and one providing an algorithm to separate microscopic polyangiitis from classical polyarteritis nodosa. Summary There is hope that a wide acceptance of the new classification principles will lead to a more uniform way to diagnose classical polyarteritis nodosa, which will facilitate clinical studies and eventually improve management.},
  author       = {Segelmark, Mårten and Selga, Daina},
  issn         = {1531-6963},
  keyword      = {nodosa,polyarteritis,hepatitis,clssification,microscopic polyangiitis,vasculitis},
  language     = {eng},
  number       = {1},
  pages        = {33--38},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Current Opinion in Rheumatology},
  title        = {The challenge of managing patients with polyarteritis nodosa.},
  url          = {http://dx.doi.org/10.1097/BOR.0b013e328011cb6f},
  volume       = {19},
  year         = {2007},
}