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Ossicular Bone Modeling in Acute Otitis Media.

Salomonsen, Rasmus Lysholdt; Hermansson, Ann LU and Cayé-Thomasen, Per (2010) In Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 31. p.1109-1114
Abstract
BACKGROUND AND OBJECTIVE:: A number of middle ear diseases are associated with pathologic bone modeling, either formative or resorptive. As such, the pathogenesis of a sclerotic mastoid has been controversial for decades. Experimental studies on acute middle ear infection have shown progressive osteoneogenesis in the bone structures surrounding the middle ear cavity, and a few studies have reported acute changes of the ossicular chain. However, detailed qualitative and quantitative information on ossicular bone modeling dynamics has not been accounted for and is thus the purpose of this study. MATERIAL AND METHODS:: The histopathology of the middle ear bone tissue structures was studied longitudinally in a rat model of acute pneumococcal... (More)
BACKGROUND AND OBJECTIVE:: A number of middle ear diseases are associated with pathologic bone modeling, either formative or resorptive. As such, the pathogenesis of a sclerotic mastoid has been controversial for decades. Experimental studies on acute middle ear infection have shown progressive osteoneogenesis in the bone structures surrounding the middle ear cavity, and a few studies have reported acute changes of the ossicular chain. However, detailed qualitative and quantitative information on ossicular bone modeling dynamics has not been accounted for and is thus the purpose of this study. MATERIAL AND METHODS:: The histopathology of the middle ear bone tissue structures was studied longitudinally in a rat model of acute pneumococcal otitis media, from Days 1 to 28 postinoculation. Resorptive and formative activity was semiquantitated for the ossicles and the bone tissue structures surrounding the middle ear cavity. RESULTS:: Qualitative and semiquantitative histopathology revealed initial osteoresorption, followed by increasing apposition of new bone in the middle ear cavity. Equivalently, the ossicular chain and joints were subject to initial resorption and subsequent new bone formation, but the changes occurred were delayed and to a far lesser extent. CONCLUSION:: A single incident of acute otitis media changes the osseous structures of the middle ear, which may alter properties of ossicular chain conduction. Modeling of ossicular bone is postponed compared with the bone tissue surrounding the middle ear cavity, and to a much lesser extent. The differentiated modeling pattern suggests that ossicular bone tissue possesses biologic properties resistant to morphologic changes. (Less)
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organization
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Contribution to journal
publication status
published
subject
in
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
volume
31
pages
1109 - 1114
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000281603200015
  • pmid:20657333
  • scopus:77956339691
ISSN
1537-4505
DOI
10.1097/MAO.0b013e3181e9becb
language
English
LU publication?
yes
id
83982d38-4dac-4c3f-836d-4a82ab308931 (old id 1644569)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20657333?dopt=Abstract
date added to LUP
2010-08-05 10:26:11
date last changed
2017-08-20 04:40:41
@article{83982d38-4dac-4c3f-836d-4a82ab308931,
  abstract     = {BACKGROUND AND OBJECTIVE:: A number of middle ear diseases are associated with pathologic bone modeling, either formative or resorptive. As such, the pathogenesis of a sclerotic mastoid has been controversial for decades. Experimental studies on acute middle ear infection have shown progressive osteoneogenesis in the bone structures surrounding the middle ear cavity, and a few studies have reported acute changes of the ossicular chain. However, detailed qualitative and quantitative information on ossicular bone modeling dynamics has not been accounted for and is thus the purpose of this study. MATERIAL AND METHODS:: The histopathology of the middle ear bone tissue structures was studied longitudinally in a rat model of acute pneumococcal otitis media, from Days 1 to 28 postinoculation. Resorptive and formative activity was semiquantitated for the ossicles and the bone tissue structures surrounding the middle ear cavity. RESULTS:: Qualitative and semiquantitative histopathology revealed initial osteoresorption, followed by increasing apposition of new bone in the middle ear cavity. Equivalently, the ossicular chain and joints were subject to initial resorption and subsequent new bone formation, but the changes occurred were delayed and to a far lesser extent. CONCLUSION:: A single incident of acute otitis media changes the osseous structures of the middle ear, which may alter properties of ossicular chain conduction. Modeling of ossicular bone is postponed compared with the bone tissue surrounding the middle ear cavity, and to a much lesser extent. The differentiated modeling pattern suggests that ossicular bone tissue possesses biologic properties resistant to morphologic changes.},
  author       = {Salomonsen, Rasmus Lysholdt and Hermansson, Ann and Cayé-Thomasen, Per},
  issn         = {1537-4505},
  language     = {eng},
  pages        = {1109--1114},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology},
  title        = {Ossicular Bone Modeling in Acute Otitis Media.},
  url          = {http://dx.doi.org/10.1097/MAO.0b013e3181e9becb},
  volume       = {31},
  year         = {2010},
}