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A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging.

Kaunisto, Erik LU ; Abrahmsen-Alami, Susanna; Borgquist, Per; Larsson, Anette; Nilsson, Bernt LU and Axelsson, Anders LU (2010) In Journal of Controlled Release 147. p.232-241
Abstract
In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using... (More)
In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Controlled Release
volume
147
pages
232 - 241
publisher
Elsevier
external identifiers
  • wos:000283566600012
  • pmid:20647024
  • scopus:77957016262
ISSN
1873-4995
DOI
10.1016/j.jconrel.2010.07.102
language
English
LU publication?
yes
id
514df704-6119-49e6-af93-5519c5cf7e40 (old id 1644709)
date added to LUP
2010-08-18 12:51:42
date last changed
2018-05-29 11:25:54
@article{514df704-6119-49e6-af93-5519c5cf7e40,
  abstract     = {In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model.},
  author       = {Kaunisto, Erik and Abrahmsen-Alami, Susanna and Borgquist, Per and Larsson, Anette and Nilsson, Bernt and Axelsson, Anders},
  issn         = {1873-4995},
  language     = {eng},
  pages        = {232--241},
  publisher    = {Elsevier},
  series       = {Journal of Controlled Release},
  title        = {A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging.},
  url          = {http://dx.doi.org/10.1016/j.jconrel.2010.07.102},
  volume       = {147},
  year         = {2010},
}