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Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome.

Källstrand, Johan; Olsson, Olle; Nehlstedt, Sara Fristedt; Ling, Mia and Nielzén, Sören LU (2010) In Neuropsychiatric Disease and Treatment 6. p.289-296
Abstract
Abnormal auditory information processing has been reported in individuals with autism spectrum disorders (ASD). In the present study auditory processing was investigated by recording auditory brainstem responses (ABRs) elicited by forward masking in adults diagnosed with Asperger syndrome (AS). Sixteen AS subjects were included in the forward masking experiment and compared to three control groups consisting of healthy individuals (n = 16), schizophrenic patients (n = 16) and attention deficit hyperactivity disorder patients (n = 16), respectively, of matching age and gender. The results showed that the AS subjects exhibited abnormally low activity in the early part of their ABRs that distinctly separated them from the three control... (More)
Abnormal auditory information processing has been reported in individuals with autism spectrum disorders (ASD). In the present study auditory processing was investigated by recording auditory brainstem responses (ABRs) elicited by forward masking in adults diagnosed with Asperger syndrome (AS). Sixteen AS subjects were included in the forward masking experiment and compared to three control groups consisting of healthy individuals (n = 16), schizophrenic patients (n = 16) and attention deficit hyperactivity disorder patients (n = 16), respectively, of matching age and gender. The results showed that the AS subjects exhibited abnormally low activity in the early part of their ABRs that distinctly separated them from the three control groups. Specifically, wave III amplitudes were significantly lower in the AS group than for all the control groups in the forward masking condition (P < 0.005), which was not the case in the baseline condition. Thus, electrophysiological measurements of ABRs to complex sound stimuli (eg, forward masking) may lead to a better understanding of the underlying neurophysiology of AS. Future studies may further point to specific ABR characteristics in AS individuals that separate them from individuals diagnosed with other neurodevelopmental diseases. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Neuropsychiatric Disease and Treatment
volume
6
pages
289 - 296
publisher
Dove Press
external identifiers
  • wos:000294953300031
  • pmid:20628629
ISSN
1176-6328
language
English
LU publication?
yes
id
49ccd929-9052-45de-bd99-332c252e94e4 (old id 1644983)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20628629?dopt=Abstract
date added to LUP
2010-08-02 11:38:43
date last changed
2018-05-29 09:42:21
@article{49ccd929-9052-45de-bd99-332c252e94e4,
  abstract     = {Abnormal auditory information processing has been reported in individuals with autism spectrum disorders (ASD). In the present study auditory processing was investigated by recording auditory brainstem responses (ABRs) elicited by forward masking in adults diagnosed with Asperger syndrome (AS). Sixteen AS subjects were included in the forward masking experiment and compared to three control groups consisting of healthy individuals (n = 16), schizophrenic patients (n = 16) and attention deficit hyperactivity disorder patients (n = 16), respectively, of matching age and gender. The results showed that the AS subjects exhibited abnormally low activity in the early part of their ABRs that distinctly separated them from the three control groups. Specifically, wave III amplitudes were significantly lower in the AS group than for all the control groups in the forward masking condition (P &lt; 0.005), which was not the case in the baseline condition. Thus, electrophysiological measurements of ABRs to complex sound stimuli (eg, forward masking) may lead to a better understanding of the underlying neurophysiology of AS. Future studies may further point to specific ABR characteristics in AS individuals that separate them from individuals diagnosed with other neurodevelopmental diseases.},
  author       = {Källstrand, Johan and Olsson, Olle and Nehlstedt, Sara Fristedt and Ling, Mia and Nielzén, Sören},
  issn         = {1176-6328},
  language     = {eng},
  pages        = {289--296},
  publisher    = {Dove Press},
  series       = {Neuropsychiatric Disease and Treatment},
  title        = {Abnormal auditory forward masking pattern in the brainstem response of individuals with Asperger syndrome.},
  volume       = {6},
  year         = {2010},
}