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Data on the effect of Angiotensin II and 6-hydroxydopamine on reactive oxygen species production, antioxidant gene expression and viability of different neuronal cell lines

Parga, Juan A. ; Rodriguez-Perez, Ana I. ; Garcia-Garrote, Maria LU orcid ; Rodriguez-Pallares, Jannette and Labandeira-Garcia, Jose L. (2018) In Data in Brief 21. p.934-942
Abstract

This article describes the effect of the oxidative stress inducers Angiotensin II and 6-hydroxydopamine (6-OHDA) on different cell lines. The levels of expression Angiotensin type 1 and type 2 receptors in different dopaminergic cell lines are shown. The data indicate that treatment with Angiotensin II and 6-OHDA increases the production of reactive oxygen species (ROS) and decreases cell viability. NRF2 is a transcription factor induced by ROS. We provide data that NRF2 overexpression increases cell viability in response to oxidative stress inducers compared to control cells, and that these inducers can, both separately and in combination, enhance the expression of NRF2-regulated genes heme oxygenase 1 (Hmox1), NAD(P)H quinone... (More)

This article describes the effect of the oxidative stress inducers Angiotensin II and 6-hydroxydopamine (6-OHDA) on different cell lines. The levels of expression Angiotensin type 1 and type 2 receptors in different dopaminergic cell lines are shown. The data indicate that treatment with Angiotensin II and 6-OHDA increases the production of reactive oxygen species (ROS) and decreases cell viability. NRF2 is a transcription factor induced by ROS. We provide data that NRF2 overexpression increases cell viability in response to oxidative stress inducers compared to control cells, and that these inducers can, both separately and in combination, enhance the expression of NRF2-regulated genes heme oxygenase 1 (Hmox1), NAD(P)H quinone dehydrogenase 1 (Nqo1) and Kruppel like factor 9 (Klf9). Interpretation of these data and additional information is presented in the research article “Angiotensin II induces oxidative stress and upregulates neuroprotective signaling from the NRF2 and KLF9 pathway in dopaminergic cells“ (Parga et al., 2018) [1].

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Dopaminergic, KLF9, NRF2, Oxidative stress, Redox signaling, Renin-angiotensin system
in
Data in Brief
volume
21
pages
934 - 942
publisher
Elsevier
external identifiers
  • scopus:85055868243
ISSN
2352-3409
DOI
10.1016/j.dib.2018.10.069
language
English
LU publication?
no
additional info
Publisher Copyright: © 2018 The Authors
id
1645bf36-31d9-4c52-a697-92759d065ccc
date added to LUP
2025-01-24 11:54:29
date last changed
2025-01-30 12:37:01
@article{1645bf36-31d9-4c52-a697-92759d065ccc,
  abstract     = {{<p>This article describes the effect of the oxidative stress inducers Angiotensin II and 6-hydroxydopamine (6-OHDA) on different cell lines. The levels of expression Angiotensin type 1 and type 2 receptors in different dopaminergic cell lines are shown. The data indicate that treatment with Angiotensin II and 6-OHDA increases the production of reactive oxygen species (ROS) and decreases cell viability. NRF2 is a transcription factor induced by ROS. We provide data that NRF2 overexpression increases cell viability in response to oxidative stress inducers compared to control cells, and that these inducers can, both separately and in combination, enhance the expression of NRF2-regulated genes heme oxygenase 1 (Hmox1), NAD(P)H quinone dehydrogenase 1 (Nqo1) and Kruppel like factor 9 (Klf9). Interpretation of these data and additional information is presented in the research article “Angiotensin II induces oxidative stress and upregulates neuroprotective signaling from the NRF2 and KLF9 pathway in dopaminergic cells“ (Parga et al., 2018) [1].</p>}},
  author       = {{Parga, Juan A. and Rodriguez-Perez, Ana I. and Garcia-Garrote, Maria and Rodriguez-Pallares, Jannette and Labandeira-Garcia, Jose L.}},
  issn         = {{2352-3409}},
  keywords     = {{Dopaminergic; KLF9; NRF2; Oxidative stress; Redox signaling; Renin-angiotensin system}},
  language     = {{eng}},
  pages        = {{934--942}},
  publisher    = {{Elsevier}},
  series       = {{Data in Brief}},
  title        = {{Data on the effect of Angiotensin II and 6-hydroxydopamine on reactive oxygen species production, antioxidant gene expression and viability of different neuronal cell lines}},
  url          = {{http://dx.doi.org/10.1016/j.dib.2018.10.069}},
  doi          = {{10.1016/j.dib.2018.10.069}},
  volume       = {{21}},
  year         = {{2018}},
}