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In diabetic retinopathy, foveal thickness of 300 mum seems to correlate with functionally significant loss of vision.

Holm, Kristina LU ; Larsson, Jörgen LU and Lövestam Adrian, Monica LU (2007) In Documenta Ophthalmologica 114(3). p.117-124
Abstract
To study the relationship between foveal thickness assessed by optical coherence tomography (OCT) and foveal function measured with multi focal electroretinography (mfERG) in patients with non-proliferative diabetic retinopathy, and with no previous laser treatment. Twenty-six eyes from 18 diabetic patients (13 men), aged 59 years, (range 28-79 years), diabetes duration 15 years, (range 2-27 years), with a macular thickness between 200 and 600 mu m were evaluated by mfERG, visual acuity (ETDRS score) and OCT. Mean amplitudes and implicit times of the mfERG responses were analyzed within the four innermost (14 degrees) of the six concentric rings. For comparison with the results from the OCT (diameter of measured area = 6 mm) we analyzed... (More)
To study the relationship between foveal thickness assessed by optical coherence tomography (OCT) and foveal function measured with multi focal electroretinography (mfERG) in patients with non-proliferative diabetic retinopathy, and with no previous laser treatment. Twenty-six eyes from 18 diabetic patients (13 men), aged 59 years, (range 28-79 years), diabetes duration 15 years, (range 2-27 years), with a macular thickness between 200 and 600 mu m were evaluated by mfERG, visual acuity (ETDRS score) and OCT. Mean amplitudes and implicit times of the mfERG responses were analyzed within the four innermost (14 degrees) of the six concentric rings. For comparison with the results from the OCT (diameter of measured area = 6 mm) we analyzed the summed response from the first and second ring (central zone), corresponding to the central area of the OCT. The third(zone 2) and fourth (zone 3)of the four innermost of the six concentric rings measured by the mfERG corresponding to the second and third area of OCT. An increased macular thickness in the central area of the OCT correlated to reduced amplitudes (r = -0.541; P = 0.004) and prolonged implicit times (r = 0.548; P = 0.004) in the central zone of the mfERG, and inversely correlated with visual acuity, -0.49; P = 0.045. Retinal thickness in the second area was correlated to prolonged implicit times in the second mfERG zone (r = -0.416; P = 0.034). No correlations were found for the third area of the OCT. When macular thickness exceeded 300 mu m the decrease of amplitudes and prolonged implicit times, measured by mfERG, seemed to be more pronounced. In conclusion increased macular thickness is correlated with reduced amplitudes and prolonged implicit times on the mf ERG and worse visual acuity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
mfERG, OCT, diabetic retinopathy, macular edema
in
Documenta Ophthalmologica
volume
114
issue
3
pages
117 - 124
publisher
Springer
external identifiers
  • wos:000246149800002
  • scopus:34247635779
ISSN
1573-2622
DOI
10.1007/s10633-006-9044-7
language
English
LU publication?
yes
id
ac9e4882-f10d-4a84-8003-b23709963b4a (old id 164699)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17242898&dopt=Abstract
date added to LUP
2007-07-16 08:21:21
date last changed
2017-08-27 04:14:04
@article{ac9e4882-f10d-4a84-8003-b23709963b4a,
  abstract     = {To study the relationship between foveal thickness assessed by optical coherence tomography (OCT) and foveal function measured with multi focal electroretinography (mfERG) in patients with non-proliferative diabetic retinopathy, and with no previous laser treatment. Twenty-six eyes from 18 diabetic patients (13 men), aged 59 years, (range 28-79 years), diabetes duration 15 years, (range 2-27 years), with a macular thickness between 200 and 600 mu m were evaluated by mfERG, visual acuity (ETDRS score) and OCT. Mean amplitudes and implicit times of the mfERG responses were analyzed within the four innermost (14 degrees) of the six concentric rings. For comparison with the results from the OCT (diameter of measured area = 6 mm) we analyzed the summed response from the first and second ring (central zone), corresponding to the central area of the OCT. The third(zone 2) and fourth (zone 3)of the four innermost of the six concentric rings measured by the mfERG corresponding to the second and third area of OCT. An increased macular thickness in the central area of the OCT correlated to reduced amplitudes (r = -0.541; P = 0.004) and prolonged implicit times (r = 0.548; P = 0.004) in the central zone of the mfERG, and inversely correlated with visual acuity, -0.49; P = 0.045. Retinal thickness in the second area was correlated to prolonged implicit times in the second mfERG zone (r = -0.416; P = 0.034). No correlations were found for the third area of the OCT. When macular thickness exceeded 300 mu m the decrease of amplitudes and prolonged implicit times, measured by mfERG, seemed to be more pronounced. In conclusion increased macular thickness is correlated with reduced amplitudes and prolonged implicit times on the mf ERG and worse visual acuity.},
  author       = {Holm, Kristina and Larsson, Jörgen and Lövestam Adrian, Monica},
  issn         = {1573-2622},
  keyword      = {mfERG,OCT,diabetic retinopathy,macular edema},
  language     = {eng},
  number       = {3},
  pages        = {117--124},
  publisher    = {Springer},
  series       = {Documenta Ophthalmologica},
  title        = {In diabetic retinopathy, foveal thickness of 300 mum seems to correlate with functionally significant loss of vision.},
  url          = {http://dx.doi.org/10.1007/s10633-006-9044-7},
  volume       = {114},
  year         = {2007},
}