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Type II collagen without adjuvant induces eosinophilic arthritis.

Bockermann, Robert LU and Holmdahl, Rikard LU (2007) In European Journal of Immunology 37(2). p.540-548
Abstract
Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without any adjuvant, was sufficient to induce chronic arthritis in a mouse with transgenic T cells specific for type II collagen. The arthritis was accompanied by infiltration of eosinophils into the synovial tissue and the disease could be blocked with neutralizing anti-IL-5 antibodies. To our knowledge, this is the first description of an eosinophilic... (More)
Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without any adjuvant, was sufficient to induce chronic arthritis in a mouse with transgenic T cells specific for type II collagen. The arthritis was accompanied by infiltration of eosinophils into the synovial tissue and the disease could be blocked with neutralizing anti-IL-5 antibodies. To our knowledge, this is the first description of an eosinophilic disease form of destructive arthritis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chronic arthritis, Eosinophils, IL-5, Th2, Th1
in
European Journal of Immunology
volume
37
issue
2
pages
540 - 548
publisher
John Wiley & Sons
external identifiers
  • wos:000244422300029
  • scopus:33947721304
ISSN
1521-4141
DOI
10.1002/eji.200636191
language
English
LU publication?
yes
id
2e1150ea-6ede-4e41-903f-909bf33cc16d (old id 164752)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17236234&dopt=Abstract
date added to LUP
2007-07-10 14:37:41
date last changed
2017-01-01 05:12:48
@article{2e1150ea-6ede-4e41-903f-909bf33cc16d,
  abstract     = {Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without any adjuvant, was sufficient to induce chronic arthritis in a mouse with transgenic T cells specific for type II collagen. The arthritis was accompanied by infiltration of eosinophils into the synovial tissue and the disease could be blocked with neutralizing anti-IL-5 antibodies. To our knowledge, this is the first description of an eosinophilic disease form of destructive arthritis.},
  author       = {Bockermann, Robert and Holmdahl, Rikard},
  issn         = {1521-4141},
  keyword      = {Chronic arthritis,Eosinophils,IL-5,Th2,Th1},
  language     = {eng},
  number       = {2},
  pages        = {540--548},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Immunology},
  title        = {Type II collagen without adjuvant induces eosinophilic arthritis.},
  url          = {http://dx.doi.org/10.1002/eji.200636191},
  volume       = {37},
  year         = {2007},
}