Type II collagen without adjuvant induces eosinophilic arthritis.
(2007) In European Journal of Immunology 37(2). p.540-548- Abstract
- Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without any adjuvant, was sufficient to induce chronic arthritis in a mouse with transgenic T cells specific for type II collagen. The arthritis was accompanied by infiltration of eosinophils into the synovial tissue and the disease could be blocked with neutralizing anti-IL-5 antibodies. To our knowledge, this is the first description of an eosinophilic... (More)
- Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without any adjuvant, was sufficient to induce chronic arthritis in a mouse with transgenic T cells specific for type II collagen. The arthritis was accompanied by infiltration of eosinophils into the synovial tissue and the disease could be blocked with neutralizing anti-IL-5 antibodies. To our knowledge, this is the first description of an eosinophilic disease form of destructive arthritis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/164752
- author
- Bockermann, Robert LU and Holmdahl, Rikard LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chronic arthritis, Eosinophils, IL-5, Th2, Th1
- in
- European Journal of Immunology
- volume
- 37
- issue
- 2
- pages
- 540 - 548
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000244422300029
- scopus:33947721304
- ISSN
- 1521-4141
- DOI
- 10.1002/eji.200636191
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 2e1150ea-6ede-4e41-903f-909bf33cc16d (old id 164752)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17236234&dopt=Abstract
- date added to LUP
- 2016-04-01 12:31:03
- date last changed
- 2022-02-26 08:11:13
@article{2e1150ea-6ede-4e41-903f-909bf33cc16d, abstract = {{Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without any adjuvant, was sufficient to induce chronic arthritis in a mouse with transgenic T cells specific for type II collagen. The arthritis was accompanied by infiltration of eosinophils into the synovial tissue and the disease could be blocked with neutralizing anti-IL-5 antibodies. To our knowledge, this is the first description of an eosinophilic disease form of destructive arthritis.}}, author = {{Bockermann, Robert and Holmdahl, Rikard}}, issn = {{1521-4141}}, keywords = {{Chronic arthritis; Eosinophils; IL-5; Th2; Th1}}, language = {{eng}}, number = {{2}}, pages = {{540--548}}, publisher = {{John Wiley & Sons Inc.}}, series = {{European Journal of Immunology}}, title = {{Type II collagen without adjuvant induces eosinophilic arthritis.}}, url = {{http://dx.doi.org/10.1002/eji.200636191}}, doi = {{10.1002/eji.200636191}}, volume = {{37}}, year = {{2007}}, }