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Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12).

Panagopoulos, Ioannis LU ; Kerndrup, Gitte; Carlsen, Niels; Strömbeck, Bodil LU ; Isaksson, Margareth LU and Johansson, Bertil LU (2007) In British Journal of Haematology 136(2). p.294-296
Abstract
Three NUP98 chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T-ALL): NUP98/ADD3, NUP98/CCDC28A, and NUP98/RAP1GDS1. We report a T-ALL with t(11;18)(p15;q12) resulting in a novel NUP98 fusion. Fluorescent in situ hybridisation showed NUP98 and SET binding protein 1(SETBP1) fusion signals; other analyses showed that exon 12 of NUP98 was fused in-frame with exon 5 of SETBP1. Nested polymerase chain reaction did not amplify the reciprocal SETBP1/NUP98, suggesting that NUP98/SETBP1 transcript is pathogenetically important. SETBP1 has previously not been implicated in leukaemias; however, it encodes a protein that specifically interacts with SET, fused to NUP214 in a case of acute undifferentiated leukaemia.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Haematology
volume
136
issue
2
pages
294 - 296
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000243298200013
  • scopus:33845906373
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2006.06410.x
language
English
LU publication?
yes
id
6bc634fe-5ff8-4aa3-8d0c-96ea402b288a (old id 164793)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17233820&dopt=Abstract
date added to LUP
2007-07-09 09:29:41
date last changed
2017-08-13 03:48:32
@article{6bc634fe-5ff8-4aa3-8d0c-96ea402b288a,
  abstract     = {Three NUP98 chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T-ALL): NUP98/ADD3, NUP98/CCDC28A, and NUP98/RAP1GDS1. We report a T-ALL with t(11;18)(p15;q12) resulting in a novel NUP98 fusion. Fluorescent in situ hybridisation showed NUP98 and SET binding protein 1(SETBP1) fusion signals; other analyses showed that exon 12 of NUP98 was fused in-frame with exon 5 of SETBP1. Nested polymerase chain reaction did not amplify the reciprocal SETBP1/NUP98, suggesting that NUP98/SETBP1 transcript is pathogenetically important. SETBP1 has previously not been implicated in leukaemias; however, it encodes a protein that specifically interacts with SET, fused to NUP214 in a case of acute undifferentiated leukaemia.},
  author       = {Panagopoulos, Ioannis and Kerndrup, Gitte and Carlsen, Niels and Strömbeck, Bodil and Isaksson, Margareth and Johansson, Bertil},
  issn         = {0007-1048},
  language     = {eng},
  number       = {2},
  pages        = {294--296},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12).},
  url          = {http://dx.doi.org/10.1111/j.1365-2141.2006.06410.x},
  volume       = {136},
  year         = {2007},
}