Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12).
(2007) In British Journal of Haematology 136(2). p.294-296- Abstract
- Three NUP98 chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T-ALL): NUP98/ADD3, NUP98/CCDC28A, and NUP98/RAP1GDS1. We report a T-ALL with t(11;18)(p15;q12) resulting in a novel NUP98 fusion. Fluorescent in situ hybridisation showed NUP98 and SET binding protein 1(SETBP1) fusion signals; other analyses showed that exon 12 of NUP98 was fused in-frame with exon 5 of SETBP1. Nested polymerase chain reaction did not amplify the reciprocal SETBP1/NUP98, suggesting that NUP98/SETBP1 transcript is pathogenetically important. SETBP1 has previously not been implicated in leukaemias; however, it encodes a protein that specifically interacts with SET, fused to NUP214 in a case of acute undifferentiated leukaemia.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/164793
- author
- Panagopoulos, Ioannis LU ; Kerndrup, Gitte ; Carlsen, Niels ; Strömbeck, Bodil LU ; Isaksson, Margareth LU and Johansson, Bertil LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Haematology
- volume
- 136
- issue
- 2
- pages
- 294 - 296
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000243298200013
- scopus:33845906373
- ISSN
- 0007-1048
- DOI
- 10.1111/j.1365-2141.2006.06410.x
- language
- English
- LU publication?
- yes
- id
- 6bc634fe-5ff8-4aa3-8d0c-96ea402b288a (old id 164793)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17233820&dopt=Abstract
- date added to LUP
- 2016-04-01 12:36:59
- date last changed
- 2022-01-27 07:28:29
@article{6bc634fe-5ff8-4aa3-8d0c-96ea402b288a, abstract = {{Three NUP98 chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T-ALL): NUP98/ADD3, NUP98/CCDC28A, and NUP98/RAP1GDS1. We report a T-ALL with t(11;18)(p15;q12) resulting in a novel NUP98 fusion. Fluorescent in situ hybridisation showed NUP98 and SET binding protein 1(SETBP1) fusion signals; other analyses showed that exon 12 of NUP98 was fused in-frame with exon 5 of SETBP1. Nested polymerase chain reaction did not amplify the reciprocal SETBP1/NUP98, suggesting that NUP98/SETBP1 transcript is pathogenetically important. SETBP1 has previously not been implicated in leukaemias; however, it encodes a protein that specifically interacts with SET, fused to NUP214 in a case of acute undifferentiated leukaemia.}}, author = {{Panagopoulos, Ioannis and Kerndrup, Gitte and Carlsen, Niels and Strömbeck, Bodil and Isaksson, Margareth and Johansson, Bertil}}, issn = {{0007-1048}}, language = {{eng}}, number = {{2}}, pages = {{294--296}}, publisher = {{Wiley-Blackwell}}, series = {{British Journal of Haematology}}, title = {{Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12).}}, url = {{http://dx.doi.org/10.1111/j.1365-2141.2006.06410.x}}, doi = {{10.1111/j.1365-2141.2006.06410.x}}, volume = {{136}}, year = {{2007}}, }