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Fimbrial lectins influence the chemokine repertoire in the urinary tract mucosa.

Godaly, Gabriela LU ; Otto, Gisela LU ; Burdick, M D; Strieter, R M and Svanborg, Catharina LU (2007) In Kidney International 71(8). p.778-786
Abstract
The defense against mucosal infections relies on chemokines that recruit inflammatory cells to the mucosa. This study examined if the chemokine response to uro-pathogenic Escherichia coli is influenced by fimbrial expression. The CXC (CXCL1, CXCL5, CXCL8, CXCL9, CXCL10) and CC chemokines (CCL2, CCL3, CCL5) were quantified after in vitro infection of uro-epithelial cells with a fimbriated E. coli pyelonephritis isolate, or with P or type 1 fimbriated transformants of an avirulent E. coli K-12 strain. The response profile was shown to vary with the fimbrial type. Type 1 fimbriated E. coli elicited mainly CXCL1 and CXCL8, whereas P fimbriated E. coli stimulated CCL2 and CCL5 and class II were more potent chemokine inducers than class III P... (More)
The defense against mucosal infections relies on chemokines that recruit inflammatory cells to the mucosa. This study examined if the chemokine response to uro-pathogenic Escherichia coli is influenced by fimbrial expression. The CXC (CXCL1, CXCL5, CXCL8, CXCL9, CXCL10) and CC chemokines (CCL2, CCL3, CCL5) were quantified after in vitro infection of uro-epithelial cells with a fimbriated E. coli pyelonephritis isolate, or with P or type 1 fimbriated transformants of an avirulent E. coli K-12 strain. The response profile was shown to vary with the fimbrial type. Type 1 fimbriated E. coli elicited mainly CXCL1 and CXCL8, whereas P fimbriated E. coli stimulated CCL2 and CCL5 and class II were more potent chemokine inducers than class III P fimbriae. Chemokines were also quantified in urine samples from 73 patients with febrile urinary tract infection, and analyzed as a function of disease severity and fimbrial expression by the strain infecting each patient. A complex CXC and CC chemokine response was detected in patient urine, with a significant influence of the fimbrial type. The results show that virulence factors like fimbriae may modify the mucosal chemokine response. This mechanism may allow the host to adjust the inflammatory cell infiltrate to fit the infecting strain. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
urinary tract infection, fimbriae, chemokines, Escherichia coli
in
Kidney International
volume
71
issue
8
pages
778 - 786
publisher
Nature Publishing Group
external identifiers
  • wos:000245741800012
  • scopus:34247252575
ISSN
1523-1755
DOI
10.1038/sj.ki.5002076
language
English
LU publication?
yes
id
e53ce683-3594-452e-8020-c6676d9e7520 (old id 164856)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17228365&dopt=Abstract
date added to LUP
2007-07-04 09:13:54
date last changed
2017-03-12 04:13:05
@article{e53ce683-3594-452e-8020-c6676d9e7520,
  abstract     = {The defense against mucosal infections relies on chemokines that recruit inflammatory cells to the mucosa. This study examined if the chemokine response to uro-pathogenic Escherichia coli is influenced by fimbrial expression. The CXC (CXCL1, CXCL5, CXCL8, CXCL9, CXCL10) and CC chemokines (CCL2, CCL3, CCL5) were quantified after in vitro infection of uro-epithelial cells with a fimbriated E. coli pyelonephritis isolate, or with P or type 1 fimbriated transformants of an avirulent E. coli K-12 strain. The response profile was shown to vary with the fimbrial type. Type 1 fimbriated E. coli elicited mainly CXCL1 and CXCL8, whereas P fimbriated E. coli stimulated CCL2 and CCL5 and class II were more potent chemokine inducers than class III P fimbriae. Chemokines were also quantified in urine samples from 73 patients with febrile urinary tract infection, and analyzed as a function of disease severity and fimbrial expression by the strain infecting each patient. A complex CXC and CC chemokine response was detected in patient urine, with a significant influence of the fimbrial type. The results show that virulence factors like fimbriae may modify the mucosal chemokine response. This mechanism may allow the host to adjust the inflammatory cell infiltrate to fit the infecting strain.},
  author       = {Godaly, Gabriela and Otto, Gisela and Burdick, M D and Strieter, R M and Svanborg, Catharina},
  issn         = {1523-1755},
  keyword      = {urinary tract infection,fimbriae,chemokines,Escherichia coli},
  language     = {eng},
  number       = {8},
  pages        = {778--786},
  publisher    = {Nature Publishing Group},
  series       = {Kidney International},
  title        = {Fimbrial lectins influence the chemokine repertoire in the urinary tract mucosa.},
  url          = {http://dx.doi.org/10.1038/sj.ki.5002076},
  volume       = {71},
  year         = {2007},
}