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Cytogenetic evolution patterns in CML post-SCT.

Karrman, Kristina LU ; Sallerfors, B; Lenhoff, S; Fioretos, Thoas LU and Johansson, Bertil LU (2007) In Bone Marrow Transplantation 39(3). p.165-171
Abstract
The cytogenetic evolution patterns in chronic myeloid leukemia (CML) after allogeneic ( allo) stem cell transplantation (SCT) are different from the ones observed in non-transplanted patients, a phenomenon suggested to be caused by the conditioning regime. We reviewed 131 CMLs displaying karyotypic evolution after SCT (122 allo, nine autologous (auto)), treated at Lund University Hospital or reported in the literature. Major route abnormalities (i.e., +8, +Ph, i(17q), +19, +21, +17 and -7) were seen in 14%, balanced aberrations in 61%, hyperdiploidy in 19%, pseudodiploidy in 79%, divergent clones in 14%, and Ph-negative clones in 21%. The breakpoints involved in secondary structural rearrangements clustered at 1q21, 1q32, 7q22, 9q34,... (More)
The cytogenetic evolution patterns in chronic myeloid leukemia (CML) after allogeneic ( allo) stem cell transplantation (SCT) are different from the ones observed in non-transplanted patients, a phenomenon suggested to be caused by the conditioning regime. We reviewed 131 CMLs displaying karyotypic evolution after SCT (122 allo, nine autologous (auto)), treated at Lund University Hospital or reported in the literature. Major route abnormalities (i.e., +8, +Ph, i(17q), +19, +21, +17 and -7) were seen in 14%, balanced aberrations in 61%, hyperdiploidy in 19%, pseudodiploidy in 79%, divergent clones in 14%, and Ph-negative clones in 21%. The breakpoints involved in secondary structural rearrangements clustered at 1q21, 1q32, 7q22, 9q34, 11q13, 11q23, 12q24, 13q14, 17q10 and 22q11. Cytogenetic abnormalities common in AML after genotoxic exposure, that is, der(1;7)(q10; p10), del(3p), -5, del(5q), -7, -17, der(17p), -18, and -21, were only rarely seen post-SCT. Comparing the cytogenetic features in relation to type of SCT revealed that balanced aberrations were significantly more common after allo than after auto SCT (64 and 22%, respectively, P = 0.03). In addition, there was a trend as regards hyperdiploidy being more common after auto (P = 0.07) and pseudodiploidy being more frequent after allo SCT (P = 0.09). Possible reasons for these differences are discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allogeneic, chronic myeloid leukemia, autologous, stem cell, transplantation, cytogenetic evolution
in
Bone Marrow Transplantation
volume
39
issue
3
pages
165 - 171
publisher
Nature Publishing Group
external identifiers
  • wos:000243725100006
  • scopus:33846589824
ISSN
1476-5365
DOI
10.1038/sj.bmt.1705560
language
English
LU publication?
yes
id
a622be52-bacd-4c5b-8190-a30f8e826ca5 (old id 165087)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17211433&dopt=Abstract
date added to LUP
2007-07-08 07:34:00
date last changed
2017-10-29 03:30:02
@article{a622be52-bacd-4c5b-8190-a30f8e826ca5,
  abstract     = {The cytogenetic evolution patterns in chronic myeloid leukemia (CML) after allogeneic ( allo) stem cell transplantation (SCT) are different from the ones observed in non-transplanted patients, a phenomenon suggested to be caused by the conditioning regime. We reviewed 131 CMLs displaying karyotypic evolution after SCT (122 allo, nine autologous (auto)), treated at Lund University Hospital or reported in the literature. Major route abnormalities (i.e., +8, +Ph, i(17q), +19, +21, +17 and -7) were seen in 14%, balanced aberrations in 61%, hyperdiploidy in 19%, pseudodiploidy in 79%, divergent clones in 14%, and Ph-negative clones in 21%. The breakpoints involved in secondary structural rearrangements clustered at 1q21, 1q32, 7q22, 9q34, 11q13, 11q23, 12q24, 13q14, 17q10 and 22q11. Cytogenetic abnormalities common in AML after genotoxic exposure, that is, der(1;7)(q10; p10), del(3p), -5, del(5q), -7, -17, der(17p), -18, and -21, were only rarely seen post-SCT. Comparing the cytogenetic features in relation to type of SCT revealed that balanced aberrations were significantly more common after allo than after auto SCT (64 and 22%, respectively, P = 0.03). In addition, there was a trend as regards hyperdiploidy being more common after auto (P = 0.07) and pseudodiploidy being more frequent after allo SCT (P = 0.09). Possible reasons for these differences are discussed.},
  author       = {Karrman, Kristina and Sallerfors, B and Lenhoff, S and Fioretos, Thoas and Johansson, Bertil},
  issn         = {1476-5365},
  keyword      = {allogeneic,chronic myeloid leukemia,autologous,stem cell,transplantation,cytogenetic evolution},
  language     = {eng},
  number       = {3},
  pages        = {165--171},
  publisher    = {Nature Publishing Group},
  series       = {Bone Marrow Transplantation},
  title        = {Cytogenetic evolution patterns in CML post-SCT.},
  url          = {http://dx.doi.org/10.1038/sj.bmt.1705560},
  volume       = {39},
  year         = {2007},
}