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Aire-ing self antigen variability and tolerance.

Holmdahl, Rikard LU (2007) In European Journal of Immunology 37(3). p.598-601
Abstract
Positional cloning of the underlying genes for the rare syndrome autoimmune polyendocrinopathy candidadiasis extrodermal dystrophy (APECED) opened a new venue of research on the role of central tolerance in autoimmunity. The associated autoimmune regulator gene (AIRE), was found to be expressed in medullary thymus epithelial cells (mTEC) in both man and mice, and to control promiscuous expression of sets of self antigens. The lack of AIRE in both mice and man led to the development of a quite specific, but also an inter-individual variable, set of autoimmune and infectious diseases. An article in this issue of the European Journal of Immunology demonstrates that several autoantigens controlled by AIRE are variably expressed in different... (More)
Positional cloning of the underlying genes for the rare syndrome autoimmune polyendocrinopathy candidadiasis extrodermal dystrophy (APECED) opened a new venue of research on the role of central tolerance in autoimmunity. The associated autoimmune regulator gene (AIRE), was found to be expressed in medullary thymus epithelial cells (mTEC) in both man and mice, and to control promiscuous expression of sets of self antigens. The lack of AIRE in both mice and man led to the development of a quite specific, but also an inter-individual variable, set of autoimmune and infectious diseases. An article in this issue of the European Journal of Immunology demonstrates that several autoantigens controlled by AIRE are variably expressed in different human individuals. Most importantly it is shown that carriers of the type 1 diabetes (T1D) associated locus IDDM2 show lower expression of insulin in mTEC, as controlled by AIRE. The genetic variability of autoantigen expression in the thymus thus seems to determine the variable predisposition to autoimmunity. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
medullary thymic epithelial cells, AIRE, diabetes, insulin
in
European Journal of Immunology
volume
37
issue
3
pages
598 - 601
publisher
John Wiley & Sons
external identifiers
  • wos:000245062700003
  • scopus:34147106416
ISSN
1521-4141
DOI
10.1002/eji.200737152
language
English
LU publication?
yes
id
9acb6080-4f7d-4ede-b273-2ffbe12d87ce (old id 165419)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17323409&dopt=Abstract
date added to LUP
2007-07-30 14:49:20
date last changed
2017-01-01 05:03:50
@misc{9acb6080-4f7d-4ede-b273-2ffbe12d87ce,
  abstract     = {Positional cloning of the underlying genes for the rare syndrome autoimmune polyendocrinopathy candidadiasis extrodermal dystrophy (APECED) opened a new venue of research on the role of central tolerance in autoimmunity. The associated autoimmune regulator gene (AIRE), was found to be expressed in medullary thymus epithelial cells (mTEC) in both man and mice, and to control promiscuous expression of sets of self antigens. The lack of AIRE in both mice and man led to the development of a quite specific, but also an inter-individual variable, set of autoimmune and infectious diseases. An article in this issue of the European Journal of Immunology demonstrates that several autoantigens controlled by AIRE are variably expressed in different human individuals. Most importantly it is shown that carriers of the type 1 diabetes (T1D) associated locus IDDM2 show lower expression of insulin in mTEC, as controlled by AIRE. The genetic variability of autoantigen expression in the thymus thus seems to determine the variable predisposition to autoimmunity.},
  author       = {Holmdahl, Rikard},
  issn         = {1521-4141},
  keyword      = {medullary thymic epithelial cells,AIRE,diabetes,insulin},
  language     = {eng},
  number       = {3},
  pages        = {598--601},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Immunology},
  title        = {Aire-ing self antigen variability and tolerance.},
  url          = {http://dx.doi.org/10.1002/eji.200737152},
  volume       = {37},
  year         = {2007},
}