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The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut

Suzuki, Keiichiro; Maruya, Mikako; Kawamoto, Shimpei; Sitnik, Katarzyna LU ; Kitamura, Hiroshi; Agace, William LU and Fagarasan, Sidonia (2010) In Immunity 33(1). p.71-83
Abstract
In the Peyer's patches (PPs), germinal centers (GCs) are chronically induced by bacteria and are the major sites for generation of gut immunoglobulin A (IgA) immune responses. Whether follicular dendritic cells (FDCs) within the GCs directly contribute to the IgA production in PPs is unknown. We showed here that direct stimulation of FDCs by bacterial products and retinoic acid synergistically enhanced the expression of the chemokine CXCL13, the survival factor BAFF, and molecules that facilitate the secretion and activation of the cytokine TGF-beta 1. A reduced production of these molecules by PP FDCs associated with deficiencies in the Toll-like receptor pathway or vitamin A resulted in decreased numbers of GC B cells and defective... (More)
In the Peyer's patches (PPs), germinal centers (GCs) are chronically induced by bacteria and are the major sites for generation of gut immunoglobulin A (IgA) immune responses. Whether follicular dendritic cells (FDCs) within the GCs directly contribute to the IgA production in PPs is unknown. We showed here that direct stimulation of FDCs by bacterial products and retinoic acid synergistically enhanced the expression of the chemokine CXCL13, the survival factor BAFF, and molecules that facilitate the secretion and activation of the cytokine TGF-beta 1. A reduced production of these molecules by PP FDCs associated with deficiencies in the Toll-like receptor pathway or vitamin A resulted in decreased numbers of GC B cells and defective generation of IgA(+) B cells within PP GCs. Our data indicate that PP FDCs are conditioned by environmental stimuli to express key factors for B cell migration, survival, and preferential generation of IgA in gut. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunity
volume
33
issue
1
pages
71 - 83
publisher
Cell Press
external identifiers
  • wos:000280418100011
  • scopus:77954898661
ISSN
1074-7613
DOI
10.1016/j.immuni.2010.07.003
language
English
LU publication?
yes
id
97f2a3f6-bf6f-48d6-8588-46673ee131d3 (old id 1654426)
date added to LUP
2010-08-30 09:47:20
date last changed
2018-07-15 03:07:56
@article{97f2a3f6-bf6f-48d6-8588-46673ee131d3,
  abstract     = {In the Peyer's patches (PPs), germinal centers (GCs) are chronically induced by bacteria and are the major sites for generation of gut immunoglobulin A (IgA) immune responses. Whether follicular dendritic cells (FDCs) within the GCs directly contribute to the IgA production in PPs is unknown. We showed here that direct stimulation of FDCs by bacterial products and retinoic acid synergistically enhanced the expression of the chemokine CXCL13, the survival factor BAFF, and molecules that facilitate the secretion and activation of the cytokine TGF-beta 1. A reduced production of these molecules by PP FDCs associated with deficiencies in the Toll-like receptor pathway or vitamin A resulted in decreased numbers of GC B cells and defective generation of IgA(+) B cells within PP GCs. Our data indicate that PP FDCs are conditioned by environmental stimuli to express key factors for B cell migration, survival, and preferential generation of IgA in gut.},
  author       = {Suzuki, Keiichiro and Maruya, Mikako and Kawamoto, Shimpei and Sitnik, Katarzyna and Kitamura, Hiroshi and Agace, William and Fagarasan, Sidonia},
  issn         = {1074-7613},
  language     = {eng},
  number       = {1},
  pages        = {71--83},
  publisher    = {Cell Press},
  series       = {Immunity},
  title        = {The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut},
  url          = {http://dx.doi.org/10.1016/j.immuni.2010.07.003},
  volume       = {33},
  year         = {2010},
}