The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut
(2010) In Immunity 33(1). p.71-83- Abstract
- In the Peyer's patches (PPs), germinal centers (GCs) are chronically induced by bacteria and are the major sites for generation of gut immunoglobulin A (IgA) immune responses. Whether follicular dendritic cells (FDCs) within the GCs directly contribute to the IgA production in PPs is unknown. We showed here that direct stimulation of FDCs by bacterial products and retinoic acid synergistically enhanced the expression of the chemokine CXCL13, the survival factor BAFF, and molecules that facilitate the secretion and activation of the cytokine TGF-beta 1. A reduced production of these molecules by PP FDCs associated with deficiencies in the Toll-like receptor pathway or vitamin A resulted in decreased numbers of GC B cells and defective... (More)
- In the Peyer's patches (PPs), germinal centers (GCs) are chronically induced by bacteria and are the major sites for generation of gut immunoglobulin A (IgA) immune responses. Whether follicular dendritic cells (FDCs) within the GCs directly contribute to the IgA production in PPs is unknown. We showed here that direct stimulation of FDCs by bacterial products and retinoic acid synergistically enhanced the expression of the chemokine CXCL13, the survival factor BAFF, and molecules that facilitate the secretion and activation of the cytokine TGF-beta 1. A reduced production of these molecules by PP FDCs associated with deficiencies in the Toll-like receptor pathway or vitamin A resulted in decreased numbers of GC B cells and defective generation of IgA(+) B cells within PP GCs. Our data indicate that PP FDCs are conditioned by environmental stimuli to express key factors for B cell migration, survival, and preferential generation of IgA in gut. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1654426
- author
- Suzuki, Keiichiro ; Maruya, Mikako ; Kawamoto, Shimpei ; Sitnik, Katarzyna LU ; Kitamura, Hiroshi ; Agace, William LU and Fagarasan, Sidonia
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunity
- volume
- 33
- issue
- 1
- pages
- 71 - 83
- publisher
- Cell Press
- external identifiers
-
- wos:000280418100011
- scopus:77954898661
- pmid:20643338
- ISSN
- 1074-7613
- DOI
- 10.1016/j.immuni.2010.07.003
- language
- English
- LU publication?
- yes
- id
- 97f2a3f6-bf6f-48d6-8588-46673ee131d3 (old id 1654426)
- date added to LUP
- 2016-04-01 10:12:06
- date last changed
- 2022-04-27 19:37:56
@article{97f2a3f6-bf6f-48d6-8588-46673ee131d3, abstract = {{In the Peyer's patches (PPs), germinal centers (GCs) are chronically induced by bacteria and are the major sites for generation of gut immunoglobulin A (IgA) immune responses. Whether follicular dendritic cells (FDCs) within the GCs directly contribute to the IgA production in PPs is unknown. We showed here that direct stimulation of FDCs by bacterial products and retinoic acid synergistically enhanced the expression of the chemokine CXCL13, the survival factor BAFF, and molecules that facilitate the secretion and activation of the cytokine TGF-beta 1. A reduced production of these molecules by PP FDCs associated with deficiencies in the Toll-like receptor pathway or vitamin A resulted in decreased numbers of GC B cells and defective generation of IgA(+) B cells within PP GCs. Our data indicate that PP FDCs are conditioned by environmental stimuli to express key factors for B cell migration, survival, and preferential generation of IgA in gut.}}, author = {{Suzuki, Keiichiro and Maruya, Mikako and Kawamoto, Shimpei and Sitnik, Katarzyna and Kitamura, Hiroshi and Agace, William and Fagarasan, Sidonia}}, issn = {{1074-7613}}, language = {{eng}}, number = {{1}}, pages = {{71--83}}, publisher = {{Cell Press}}, series = {{Immunity}}, title = {{The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut}}, url = {{http://dx.doi.org/10.1016/j.immuni.2010.07.003}}, doi = {{10.1016/j.immuni.2010.07.003}}, volume = {{33}}, year = {{2010}}, }