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Absence of the common Insulin-like growth factor-1 19-repeat allele is associated with early age at breast cancer diagnosis in multiparous women.

Bågeman, Erika LU ; Ingvar, Christian LU ; Rose, Carsten LU and Jernström, Helena LU (2007) In British Journal of Cancer 96. p.712-717
Abstract
Multiparity decreases the risk of breast cancer in white women, whereas it is a risk factor in black women < 50 years. Early-onset breast cancer (< 50 years) has been associated with high insulin-like growth factor-I (IGF-I) levels. Absence of the common IGFI 19 cytosine-adenine ( CA)- repeat allele (IGFI-19/-19) inverts the effect of several non-genetic factors on breast cancer risk but the interaction between IGFI-19/-19 and multiparity on breast cancer risk is unknown. As IGFI-19/-19, multiparity and early-onset breast cancer are more common in black than in white women, we aimed to study whether multiparity combined with IGFI-19/-19 increases the risk of early-onset breast cancer. Four hundred and three breast cancer patients... (More)
Multiparity decreases the risk of breast cancer in white women, whereas it is a risk factor in black women < 50 years. Early-onset breast cancer (< 50 years) has been associated with high insulin-like growth factor-I (IGF-I) levels. Absence of the common IGFI 19 cytosine-adenine ( CA)- repeat allele (IGFI-19/-19) inverts the effect of several non-genetic factors on breast cancer risk but the interaction between IGFI-19/-19 and multiparity on breast cancer risk is unknown. As IGFI-19/-19, multiparity and early-onset breast cancer are more common in black than in white women, we aimed to study whether multiparity combined with IGFI-19/-19 increases the risk of early-onset breast cancer. Four hundred and three breast cancer patients diagnosed in Lund, Sweden, at age 25 - 99 years were genotyped for the IGFI CA-repeat length using fragment analysis. Overall, 12.9% carried the IGFI-19/-19 genotype. There was a highly significant interaction between multiparity and IGFI-19/-19 on age at breast cancer diagnosis ( P = 0.007). Among IGFI-19/-19 patients, multiparity was associated with a 9.2 year earlier age at diagnosis compared with uniparity or nulliparity ( P = 0.006). Multiparity combined with IGFI-19/-19 was associated with an early age at breast cancer diagnosis. If confirmed, IGFI-19/-19 may help identify a subgroup of women for earlier breast cancer screening. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
early-onset breast cancer, IGF1 genotype, multiparity
in
British Journal of Cancer
volume
96
pages
712 - 717
publisher
Nature Publishing Group
external identifiers
  • wos:000244715400006
  • scopus:33847733113
ISSN
1532-1827
DOI
10.1038/sj.bjc.6603632
language
English
LU publication?
yes
id
132233de-1eae-46df-99ab-8a36c1b7ba56 (old id 165563)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17311016&dopt=Abstract
date added to LUP
2007-07-20 15:26:32
date last changed
2017-01-01 05:00:28
@article{132233de-1eae-46df-99ab-8a36c1b7ba56,
  abstract     = {Multiparity decreases the risk of breast cancer in white women, whereas it is a risk factor in black women &lt; 50 years. Early-onset breast cancer (&lt; 50 years) has been associated with high insulin-like growth factor-I (IGF-I) levels. Absence of the common IGFI 19 cytosine-adenine ( CA)- repeat allele (IGFI-19/-19) inverts the effect of several non-genetic factors on breast cancer risk but the interaction between IGFI-19/-19 and multiparity on breast cancer risk is unknown. As IGFI-19/-19, multiparity and early-onset breast cancer are more common in black than in white women, we aimed to study whether multiparity combined with IGFI-19/-19 increases the risk of early-onset breast cancer. Four hundred and three breast cancer patients diagnosed in Lund, Sweden, at age 25 - 99 years were genotyped for the IGFI CA-repeat length using fragment analysis. Overall, 12.9% carried the IGFI-19/-19 genotype. There was a highly significant interaction between multiparity and IGFI-19/-19 on age at breast cancer diagnosis ( P = 0.007). Among IGFI-19/-19 patients, multiparity was associated with a 9.2 year earlier age at diagnosis compared with uniparity or nulliparity ( P = 0.006). Multiparity combined with IGFI-19/-19 was associated with an early age at breast cancer diagnosis. If confirmed, IGFI-19/-19 may help identify a subgroup of women for earlier breast cancer screening.},
  author       = {Bågeman, Erika and Ingvar, Christian and Rose, Carsten and Jernström, Helena},
  issn         = {1532-1827},
  keyword      = {early-onset breast cancer,IGF1 genotype,multiparity},
  language     = {eng},
  pages        = {712--717},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Absence of the common Insulin-like growth factor-1 19-repeat allele is associated with early age at breast cancer diagnosis in multiparous women.},
  url          = {http://dx.doi.org/10.1038/sj.bjc.6603632},
  volume       = {96},
  year         = {2007},
}