Primer: comparative genetics of animal models of arthritis--a tool to resolve complexity.
(2007) In Nature Clinical Practice Rheumatology 3(2). p.104-111- Abstract
- Complex traits, including inflammatory rheumatic diseases, have important genetic features, but most of the responsible genes have not been conclusively identified. Genetic analysis of inbred animal models and comparative genetics - the comparison of genes between different species - might help to identify the crucial genes and to investigate more directly the biology involved. Genome-wide linkage analysis of particular genes can be assessed by genetic segregation studies, whereas disease pathways can be delineated by the use of congenic strains. To clone disease genes, the traits need to be transformed so that they are inherited in a more Mendelian manner: achieving this pattern requires isolation of the locus on a genetic background that... (More)
- Complex traits, including inflammatory rheumatic diseases, have important genetic features, but most of the responsible genes have not been conclusively identified. Genetic analysis of inbred animal models and comparative genetics - the comparison of genes between different species - might help to identify the crucial genes and to investigate more directly the biology involved. Genome-wide linkage analysis of particular genes can be assessed by genetic segregation studies, whereas disease pathways can be delineated by the use of congenic strains. To clone disease genes, the traits need to be transformed so that they are inherited in a more Mendelian manner: achieving this pattern requires isolation of the locus on a genetic background that allows high penetrance by minimization of the size of congenic fragments, genetic manipulations without associated artifacts, or identification of highly penetrant mutations by phenotypic selection. Although almost one hundred quantitative trait loci for arthritis have been identified, only a few genes have so far been positionally cloned. In this Review we highlight the possibilities of using animal models to identify genes associated with complex diseases like arthritis, illustrated with available findings for genes such as those encoding major histocompatibility complex class II, neutrophil cytosolic factor 1 (Ncf1/p47(phox)) and ZAP70. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/165723
- author
- Holmdahl, Rikard LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- disease, polygenic, autoimmunity, experimental animal models, major histocompatibility complex, linkage analysis
- in
- Nature Clinical Practice Rheumatology
- volume
- 3
- issue
- 2
- pages
- 104 - 111
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000243966500011
- scopus:33847077246
- pmid:17299448
- ISSN
- 1745-8382
- DOI
- 10.1038/ncprheum0400
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 1ed05dd4-3b74-465e-baab-aaa5cbd3cacb (old id 165723)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17299448&dopt=Abstract
- date added to LUP
- 2016-04-01 11:49:47
- date last changed
- 2022-01-26 18:52:25
@article{1ed05dd4-3b74-465e-baab-aaa5cbd3cacb,
abstract = {{Complex traits, including inflammatory rheumatic diseases, have important genetic features, but most of the responsible genes have not been conclusively identified. Genetic analysis of inbred animal models and comparative genetics - the comparison of genes between different species - might help to identify the crucial genes and to investigate more directly the biology involved. Genome-wide linkage analysis of particular genes can be assessed by genetic segregation studies, whereas disease pathways can be delineated by the use of congenic strains. To clone disease genes, the traits need to be transformed so that they are inherited in a more Mendelian manner: achieving this pattern requires isolation of the locus on a genetic background that allows high penetrance by minimization of the size of congenic fragments, genetic manipulations without associated artifacts, or identification of highly penetrant mutations by phenotypic selection. Although almost one hundred quantitative trait loci for arthritis have been identified, only a few genes have so far been positionally cloned. In this Review we highlight the possibilities of using animal models to identify genes associated with complex diseases like arthritis, illustrated with available findings for genes such as those encoding major histocompatibility complex class II, neutrophil cytosolic factor 1 (Ncf1/p47(phox)) and ZAP70.}},
author = {{Holmdahl, Rikard}},
issn = {{1745-8382}},
keywords = {{disease; polygenic; autoimmunity; experimental animal models; major histocompatibility complex; linkage analysis}},
language = {{eng}},
number = {{2}},
pages = {{104--111}},
publisher = {{Nature Publishing Group}},
series = {{Nature Clinical Practice Rheumatology}},
title = {{Primer: comparative genetics of animal models of arthritis--a tool to resolve complexity.}},
url = {{http://dx.doi.org/10.1038/ncprheum0400}},
doi = {{10.1038/ncprheum0400}},
volume = {{3}},
year = {{2007}},
}