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Electrophysiological Assessment of Retinal Function During 6 Months of Bevacizumab Treatment in Neovascular Age-Related Macular Degeneration

Pedersen, Karen Bjerg; Moller, Flemming; Sjolie, Anne Katrin and Andréasson, Sten LU (2010) In Retina 30(7). p.1025-1033
Abstract
Purpose: The purpose of this study was to assess the alteration of retinal function by multifocal electroretinography and full-field electroretinography in patients with age-related macular degeneration treated with bevacizumab. Methods: We performed a prospective pilot study of 26 eyes of 26 previously treatment-naive patients with neovascular age-related macular degeneration receiving intravitreal injections with 1.25 mg bevacizumab. Patients were examined with multifocal electroretinography, full-field electroretinography, optical coherence tomography, and visual acuity. Follow-up was performed at 1 week, 6 weeks, 3 months, and 6 months. Results: Mean multifocal electroretinography P1 amplitudes were significantly improved at 1 week in... (More)
Purpose: The purpose of this study was to assess the alteration of retinal function by multifocal electroretinography and full-field electroretinography in patients with age-related macular degeneration treated with bevacizumab. Methods: We performed a prospective pilot study of 26 eyes of 26 previously treatment-naive patients with neovascular age-related macular degeneration receiving intravitreal injections with 1.25 mg bevacizumab. Patients were examined with multifocal electroretinography, full-field electroretinography, optical coherence tomography, and visual acuity. Follow-up was performed at 1 week, 6 weeks, 3 months, and 6 months. Results: Mean multifocal electroretinography P1 amplitudes were significantly improved at 1 week in the central zone and after 3 and 6 months, improvement was seen in all 6 concentric rings corresponding to +/-25 degrees of the central visual field. Full-field electroretinography results indicated a decrease in cone photoreceptor function at 3 months, which was normalized at 6 months compared with baseline. Furthermore, 2 of 3 of the combined rod-cone responses showed signs of decreased retinal function at 6 months. Conclusion: Our results indicate passing signs of an altered retinal cone photoreceptor function assessed by full-field electroretinography. The results do not show any conclusive signs of global retinal toxicity after 6 months. Multifocal electroretinography results show improved photoreceptor function with no sign of focal toxicity in the central retina. RETINA 30:1025-1033, 2010 (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
full-field ERG, electrophysiology, CNV, bevacizumab, AMD, Avastin, multifocal ERG
in
Retina
volume
30
issue
7
pages
1025 - 1033
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000279635600005
  • scopus:77954712963
ISSN
0275-004X
DOI
10.1097/IAE.0b013e3181cafc8f
language
English
LU publication?
yes
id
b09a0c31-ffce-4479-a14b-e7ee9f63ffc2 (old id 1657732)
date added to LUP
2010-08-24 11:46:51
date last changed
2018-06-10 04:08:00
@article{b09a0c31-ffce-4479-a14b-e7ee9f63ffc2,
  abstract     = {Purpose: The purpose of this study was to assess the alteration of retinal function by multifocal electroretinography and full-field electroretinography in patients with age-related macular degeneration treated with bevacizumab. Methods: We performed a prospective pilot study of 26 eyes of 26 previously treatment-naive patients with neovascular age-related macular degeneration receiving intravitreal injections with 1.25 mg bevacizumab. Patients were examined with multifocal electroretinography, full-field electroretinography, optical coherence tomography, and visual acuity. Follow-up was performed at 1 week, 6 weeks, 3 months, and 6 months. Results: Mean multifocal electroretinography P1 amplitudes were significantly improved at 1 week in the central zone and after 3 and 6 months, improvement was seen in all 6 concentric rings corresponding to +/-25 degrees of the central visual field. Full-field electroretinography results indicated a decrease in cone photoreceptor function at 3 months, which was normalized at 6 months compared with baseline. Furthermore, 2 of 3 of the combined rod-cone responses showed signs of decreased retinal function at 6 months. Conclusion: Our results indicate passing signs of an altered retinal cone photoreceptor function assessed by full-field electroretinography. The results do not show any conclusive signs of global retinal toxicity after 6 months. Multifocal electroretinography results show improved photoreceptor function with no sign of focal toxicity in the central retina. RETINA 30:1025-1033, 2010},
  author       = {Pedersen, Karen Bjerg and Moller, Flemming and Sjolie, Anne Katrin and Andréasson, Sten},
  issn         = {0275-004X},
  keyword      = {full-field ERG,electrophysiology,CNV,bevacizumab,AMD,Avastin,multifocal ERG},
  language     = {eng},
  number       = {7},
  pages        = {1025--1033},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Retina},
  title        = {Electrophysiological Assessment of Retinal Function During 6 Months of Bevacizumab Treatment in Neovascular Age-Related Macular Degeneration},
  url          = {http://dx.doi.org/10.1097/IAE.0b013e3181cafc8f},
  volume       = {30},
  year         = {2010},
}