Electrophysiological Assessment of Retinal Function During 6 Months of Bevacizumab Treatment in Neovascular Age-Related Macular Degeneration
(2010) In Retina 30(7). p.1025-1033- Abstract
- Purpose: The purpose of this study was to assess the alteration of retinal function by multifocal electroretinography and full-field electroretinography in patients with age-related macular degeneration treated with bevacizumab. Methods: We performed a prospective pilot study of 26 eyes of 26 previously treatment-naive patients with neovascular age-related macular degeneration receiving intravitreal injections with 1.25 mg bevacizumab. Patients were examined with multifocal electroretinography, full-field electroretinography, optical coherence tomography, and visual acuity. Follow-up was performed at 1 week, 6 weeks, 3 months, and 6 months. Results: Mean multifocal electroretinography P1 amplitudes were significantly improved at 1 week in... (More)
- Purpose: The purpose of this study was to assess the alteration of retinal function by multifocal electroretinography and full-field electroretinography in patients with age-related macular degeneration treated with bevacizumab. Methods: We performed a prospective pilot study of 26 eyes of 26 previously treatment-naive patients with neovascular age-related macular degeneration receiving intravitreal injections with 1.25 mg bevacizumab. Patients were examined with multifocal electroretinography, full-field electroretinography, optical coherence tomography, and visual acuity. Follow-up was performed at 1 week, 6 weeks, 3 months, and 6 months. Results: Mean multifocal electroretinography P1 amplitudes were significantly improved at 1 week in the central zone and after 3 and 6 months, improvement was seen in all 6 concentric rings corresponding to +/-25 degrees of the central visual field. Full-field electroretinography results indicated a decrease in cone photoreceptor function at 3 months, which was normalized at 6 months compared with baseline. Furthermore, 2 of 3 of the combined rod-cone responses showed signs of decreased retinal function at 6 months. Conclusion: Our results indicate passing signs of an altered retinal cone photoreceptor function assessed by full-field electroretinography. The results do not show any conclusive signs of global retinal toxicity after 6 months. Multifocal electroretinography results show improved photoreceptor function with no sign of focal toxicity in the central retina. RETINA 30:1025-1033, 2010 (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1657732
- author
- Pedersen, Karen Bjerg ; Moller, Flemming ; Sjolie, Anne Katrin and Andréasson, Sten LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- full-field ERG, electrophysiology, CNV, bevacizumab, AMD, Avastin, multifocal ERG
- in
- Retina
- volume
- 30
- issue
- 7
- pages
- 1025 - 1033
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000279635600005
- scopus:77954712963
- pmid:20616681
- ISSN
- 0275-004X
- DOI
- 10.1097/IAE.0b013e3181cafc8f
- language
- English
- LU publication?
- yes
- id
- b09a0c31-ffce-4479-a14b-e7ee9f63ffc2 (old id 1657732)
- date added to LUP
- 2016-04-01 13:40:47
- date last changed
- 2022-03-21 19:47:21
@article{b09a0c31-ffce-4479-a14b-e7ee9f63ffc2,
abstract = {{Purpose: The purpose of this study was to assess the alteration of retinal function by multifocal electroretinography and full-field electroretinography in patients with age-related macular degeneration treated with bevacizumab. Methods: We performed a prospective pilot study of 26 eyes of 26 previously treatment-naive patients with neovascular age-related macular degeneration receiving intravitreal injections with 1.25 mg bevacizumab. Patients were examined with multifocal electroretinography, full-field electroretinography, optical coherence tomography, and visual acuity. Follow-up was performed at 1 week, 6 weeks, 3 months, and 6 months. Results: Mean multifocal electroretinography P1 amplitudes were significantly improved at 1 week in the central zone and after 3 and 6 months, improvement was seen in all 6 concentric rings corresponding to +/-25 degrees of the central visual field. Full-field electroretinography results indicated a decrease in cone photoreceptor function at 3 months, which was normalized at 6 months compared with baseline. Furthermore, 2 of 3 of the combined rod-cone responses showed signs of decreased retinal function at 6 months. Conclusion: Our results indicate passing signs of an altered retinal cone photoreceptor function assessed by full-field electroretinography. The results do not show any conclusive signs of global retinal toxicity after 6 months. Multifocal electroretinography results show improved photoreceptor function with no sign of focal toxicity in the central retina. RETINA 30:1025-1033, 2010}},
author = {{Pedersen, Karen Bjerg and Moller, Flemming and Sjolie, Anne Katrin and Andréasson, Sten}},
issn = {{0275-004X}},
keywords = {{full-field ERG; electrophysiology; CNV; bevacizumab; AMD; Avastin; multifocal ERG}},
language = {{eng}},
number = {{7}},
pages = {{1025--1033}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Retina}},
title = {{Electrophysiological Assessment of Retinal Function During 6 Months of Bevacizumab Treatment in Neovascular Age-Related Macular Degeneration}},
url = {{http://dx.doi.org/10.1097/IAE.0b013e3181cafc8f}},
doi = {{10.1097/IAE.0b013e3181cafc8f}},
volume = {{30}},
year = {{2010}},
}