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Circulating antipericyte autoantibodies: A Novel Modifier of Risk of Progression of Diabetic Retinopathy?

Nayak, Ramesh; Lynch, Kristian LU ; Gustavsson, Carin LU ; Kwok, Michael; Farthing-Nayak, Pamela; Agardh, Carl-David LU and Agardh, Elisabet LU (2007) In Retina 27(2). p.211-215
Abstract
Background: Antipericyte autoantibodies (APAAs) are present in high frequency among diabetic subjects with and without nonproliferative retinopathy. This study aimed to determine whether progression of retinopathy in type 2 diabetes was associated with the same medical risk factors in APAA-positive subjects as in APAA-negative subjects. Methods: Type 2 diabetic patients with nonproliferative diabetic retinopathy at baseline were followed prospectively for 2 years monitoring progression of retinopathy. Thirty-eight (21.7%) of 175 patients had progression in Early Treatment Diabetic Retinopathy Study grade by >= 2 steps in at least 1 eye. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Results:... (More)
Background: Antipericyte autoantibodies (APAAs) are present in high frequency among diabetic subjects with and without nonproliferative retinopathy. This study aimed to determine whether progression of retinopathy in type 2 diabetes was associated with the same medical risk factors in APAA-positive subjects as in APAA-negative subjects. Methods: Type 2 diabetic patients with nonproliferative diabetic retinopathy at baseline were followed prospectively for 2 years monitoring progression of retinopathy. Thirty-eight (21.7%) of 175 patients had progression in Early Treatment Diabetic Retinopathy Study grade by >= 2 steps in at least 1 eye. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Results: Progression of retinopathy was associated with HbA(1c) level (P = 0.002), diabetes duration (P = 0.03), and albumin/creatinine ratio (P = 0.02) in APAA-negative subjects but not in APAA-positive subjects. The association between progression and APAAs was strongest in the upper quartile for HbA(1c) level (>8.0%), where 71.4% of patients negative for APAAs had progression of retinopathy while only 24.1 % of patients positive for APAAs had progression (P = 0.007). Conclusion: The results suggest that APAA presence is a modifier of risk of progression of retinopathy due to hyperglycemia and that it could be useful as a biochemical marker of risk of progression of diabetic retinopathy in type 2 diabetic patients with poor metabolic control. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
circulating antipericyte autoantibodies, retinopathy, progression, type 2 diabetes
in
Retina
volume
27
issue
2
pages
211 - 215
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000246986100012
  • scopus:33846958395
ISSN
0275-004X
language
English
LU publication?
yes
id
9d2b7a14-5cd0-4c58-8db6-e87407306ba2 (old id 165808)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17290204&dopt=Abstract
date added to LUP
2007-07-26 15:08:29
date last changed
2017-01-01 07:02:46
@article{9d2b7a14-5cd0-4c58-8db6-e87407306ba2,
  abstract     = {Background: Antipericyte autoantibodies (APAAs) are present in high frequency among diabetic subjects with and without nonproliferative retinopathy. This study aimed to determine whether progression of retinopathy in type 2 diabetes was associated with the same medical risk factors in APAA-positive subjects as in APAA-negative subjects. Methods: Type 2 diabetic patients with nonproliferative diabetic retinopathy at baseline were followed prospectively for 2 years monitoring progression of retinopathy. Thirty-eight (21.7%) of 175 patients had progression in Early Treatment Diabetic Retinopathy Study grade by >= 2 steps in at least 1 eye. Serum APAAs were detected by immunofluorescence on tissue-cultured bovine retinal pericytes. Results: Progression of retinopathy was associated with HbA(1c) level (P = 0.002), diabetes duration (P = 0.03), and albumin/creatinine ratio (P = 0.02) in APAA-negative subjects but not in APAA-positive subjects. The association between progression and APAAs was strongest in the upper quartile for HbA(1c) level (>8.0%), where 71.4% of patients negative for APAAs had progression of retinopathy while only 24.1 % of patients positive for APAAs had progression (P = 0.007). Conclusion: The results suggest that APAA presence is a modifier of risk of progression of retinopathy due to hyperglycemia and that it could be useful as a biochemical marker of risk of progression of diabetic retinopathy in type 2 diabetic patients with poor metabolic control.},
  author       = {Nayak, Ramesh and Lynch, Kristian and Gustavsson, Carin and Kwok, Michael and Farthing-Nayak, Pamela and Agardh, Carl-David and Agardh, Elisabet},
  issn         = {0275-004X},
  keyword      = {circulating antipericyte autoantibodies,retinopathy,progression,type 2 diabetes},
  language     = {eng},
  number       = {2},
  pages        = {211--215},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Retina},
  title        = {Circulating antipericyte autoantibodies: A Novel Modifier of Risk of Progression of Diabetic Retinopathy?},
  volume       = {27},
  year         = {2007},
}