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Cytogenetic findings in pediatric renal cell carcinoma

Soller, Maria Johansson LU ; Kullendorff, Carl-Magnus LU ; Békássy, Albert N LU ; Alumets, Jan LU and Mertens, Fredrik LU (2007) In Cancer Genetics and Cytogenetics 173(1). p.75-80
Abstract

Adenocarcinomas of the kidney are rare childhood tumors. Only 30 cases with chromosomal abnormalities have been reported, and neither their karyotypic characteristics nor the molecular mechanisms behind their pathogenesis are clear, except for a special group of papillary tumors characterized by X-chromosome abnormalities. We have cytogenetically analyzed short-term cultured cells from two pediatric renal carcinomas, one papillary, and one chromophobe renal cell carcinoma, revealing the following karyotypes: 58-60,XX,-X,-1,+7,-8,-9,-11,-14,-15,+17,-18,-19,-21,-22 and 36,X,-X,-1,-2,-5,-6,-9,-10,-13,-17,-21/37,idem,+r/36,idem,-14,+1-2r, respectively. The findings indicate that subsets of pediatric renal cell carcinoma show karyotypes that... (More)

Adenocarcinomas of the kidney are rare childhood tumors. Only 30 cases with chromosomal abnormalities have been reported, and neither their karyotypic characteristics nor the molecular mechanisms behind their pathogenesis are clear, except for a special group of papillary tumors characterized by X-chromosome abnormalities. We have cytogenetically analyzed short-term cultured cells from two pediatric renal carcinomas, one papillary, and one chromophobe renal cell carcinoma, revealing the following karyotypes: 58-60,XX,-X,-1,+7,-8,-9,-11,-14,-15,+17,-18,-19,-21,-22 and 36,X,-X,-1,-2,-5,-6,-9,-10,-13,-17,-21/37,idem,+r/36,idem,-14,+1-2r, respectively. The findings indicate that subsets of pediatric renal cell carcinoma show karyotypes that are similar to their adult counterparts.

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keywords
Adolescent, Carcinoma, Papillary, Carcinoma, Renal Cell, Child, Chromosome Aberrations, Chromosome Banding, Humans, Karyotyping, Kidney Neoplasms, Ring Chromosomes, Tumor Cells, Cultured, Case Reports, Journal Article, Research Support, Non-U.S. Gov't
in
Cancer Genetics and Cytogenetics
volume
173
issue
1
pages
6 pages
publisher
Elsevier
external identifiers
  • wos:000244364100013
  • scopus:33846689825
  • pmid:17284375
ISSN
0165-4608
DOI
10.1016/j.cancergencyto.2006.09.018
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Clinical Genetics (013022003), Paediatrics (Lund) (013002000), Pathology, (Lund) (013030000)
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dae45ba5-48ef-4979-b495-8523dde08e8f (old id 165849)
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17284375&dopt=Abstract
date added to LUP
2016-04-01 16:10:18
date last changed
2020-01-12 19:06:17
@article{dae45ba5-48ef-4979-b495-8523dde08e8f,
  abstract     = {<p>Adenocarcinomas of the kidney are rare childhood tumors. Only 30 cases with chromosomal abnormalities have been reported, and neither their karyotypic characteristics nor the molecular mechanisms behind their pathogenesis are clear, except for a special group of papillary tumors characterized by X-chromosome abnormalities. We have cytogenetically analyzed short-term cultured cells from two pediatric renal carcinomas, one papillary, and one chromophobe renal cell carcinoma, revealing the following karyotypes: 58-60,XX,-X,-1,+7,-8,-9,-11,-14,-15,+17,-18,-19,-21,-22 and 36,X,-X,-1,-2,-5,-6,-9,-10,-13,-17,-21/37,idem,+r/36,idem,-14,+1-2r, respectively. The findings indicate that subsets of pediatric renal cell carcinoma show karyotypes that are similar to their adult counterparts.</p>},
  author       = {Soller, Maria Johansson and Kullendorff, Carl-Magnus and Békássy, Albert N and Alumets, Jan and Mertens, Fredrik},
  issn         = {0165-4608},
  language     = {eng},
  number       = {1},
  pages        = {75--80},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics},
  title        = {Cytogenetic findings in pediatric renal cell carcinoma},
  url          = {http://dx.doi.org/10.1016/j.cancergencyto.2006.09.018},
  doi          = {10.1016/j.cancergencyto.2006.09.018},
  volume       = {173},
  year         = {2007},
}