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Nerve growth factor promotes survival of new neurons in the adult hippocampus.

Frielingsdorf, Helena LU ; Simpson, Daniel R; Thal, Leon J and Pizzo, Donald P (2007) In Neurobiology of Disease 26(1). p.47-55
Abstract
xogenously provided NGF enhances cognitive performance in impaired rodents and humans and is currently a promising compound for the treatment of dementia. To investigate whether NGF-dependent cognitive improvement may be due in part to increased hippocampal neurogenesis, adult and aged male rats were treated with NGF or vehicle intracerebroventricularly for 6 or 20 days followed by evaluation of cholinergic parameters and hippocampal neurogenesis. We show that NGF increases hippocampal cholinergic activity as rapidly as 3 days after initiation of treatment. NGF treatment for 6 days did not affect proliferation of progenitor cells in the dentate gyrus granule cell layer (GCL). However, continuous NGF infusion enhanced survival of new... (More)
xogenously provided NGF enhances cognitive performance in impaired rodents and humans and is currently a promising compound for the treatment of dementia. To investigate whether NGF-dependent cognitive improvement may be due in part to increased hippocampal neurogenesis, adult and aged male rats were treated with NGF or vehicle intracerebroventricularly for 6 or 20 days followed by evaluation of cholinergic parameters and hippocampal neurogenesis. We show that NGF increases hippocampal cholinergic activity as rapidly as 3 days after initiation of treatment. NGF treatment for 6 days did not affect proliferation of progenitor cells in the dentate gyrus granule cell layer (GCL). However, continuous NGF infusion enhanced survival of new neurons in the GCL of young adult, but not aged rats. Taken together, these findings suggest that NGF, likely mediated through increased cholinergic tone, promotes neurogenesis in the adult hippocampus, which may relate to the nootropic action of NGF. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Memory, Neurogenesis, Hippocampus, NGF, Aging, Acetylcholine
in
Neurobiology of Disease
volume
26
issue
1
pages
47 - 55
publisher
Elsevier
external identifiers
  • wos:000245374000005
  • scopus:33947372594
ISSN
0969-9961
DOI
10.1016/j.nbd.2006.11.015
language
English
LU publication?
yes
id
74b5618e-33f6-4c62-970a-e20f1b3e0824 (old id 165976)
date added to LUP
2007-07-12 12:41:57
date last changed
2017-06-18 03:44:55
@article{74b5618e-33f6-4c62-970a-e20f1b3e0824,
  abstract     = {xogenously provided NGF enhances cognitive performance in impaired rodents and humans and is currently a promising compound for the treatment of dementia. To investigate whether NGF-dependent cognitive improvement may be due in part to increased hippocampal neurogenesis, adult and aged male rats were treated with NGF or vehicle intracerebroventricularly for 6 or 20 days followed by evaluation of cholinergic parameters and hippocampal neurogenesis. We show that NGF increases hippocampal cholinergic activity as rapidly as 3 days after initiation of treatment. NGF treatment for 6 days did not affect proliferation of progenitor cells in the dentate gyrus granule cell layer (GCL). However, continuous NGF infusion enhanced survival of new neurons in the GCL of young adult, but not aged rats. Taken together, these findings suggest that NGF, likely mediated through increased cholinergic tone, promotes neurogenesis in the adult hippocampus, which may relate to the nootropic action of NGF.},
  author       = {Frielingsdorf, Helena and Simpson, Daniel R and Thal, Leon J and Pizzo, Donald P},
  issn         = {0969-9961},
  keyword      = {Memory,Neurogenesis,Hippocampus,NGF,Aging,Acetylcholine},
  language     = {eng},
  number       = {1},
  pages        = {47--55},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {Nerve growth factor promotes survival of new neurons in the adult hippocampus.},
  url          = {http://dx.doi.org/10.1016/j.nbd.2006.11.015},
  volume       = {26},
  year         = {2007},
}