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Effect of iodixanol particle size on the mechanical properties of a PMMA based bone cement.

Kjellson, Fred LU ; Abdulghani, Saba LU ; Tanner, K; McCarthy, Ian LU and Lidgren, Lars LU (2007) In Journal of Materials Science: Materials in Medicine 18. p.1043-1051
Abstract
Iodixanol (IDX) is a water soluble opacifier widely used in radiographical examinations of blood vessels and neural tissue, and it has been suggested as a potential contrast media in acrylic bone cement. The effect of the iodixanol particle size on the polymerisation process of the bone cement, the molecular weight, and the quasi-static mechanical properties have been investigated in this article. The investigation was performed using radiolucent Palacos powder mixed with 8 wt% of iodixanol with particle sizes ranging from 3 to 20 mu m MMD, compared with commercial Palacos R (15 wt% ZrO2) as control. Tensile, compressive and flexural tests showed that smaller particles (groups with 3, 4, and 5 mu m particles) resulted in significantly... (More)
Iodixanol (IDX) is a water soluble opacifier widely used in radiographical examinations of blood vessels and neural tissue, and it has been suggested as a potential contrast media in acrylic bone cement. The effect of the iodixanol particle size on the polymerisation process of the bone cement, the molecular weight, and the quasi-static mechanical properties have been investigated in this article. The investigation was performed using radiolucent Palacos powder mixed with 8 wt% of iodixanol with particle sizes ranging from 3 to 20 mu m MMD, compared with commercial Palacos R (15 wt% ZrO2) as control. Tensile, compressive and flexural tests showed that smaller particles (groups with 3, 4, and 5 mu m particles) resulted in significantly lower mechanical properties than the larger particles (groups with 15, 16, and 20 mu m particles). There was no difference in molecular weight between the groups. The thermographical investigation showed that the IDX cements exhibit substantially lower maximum temperatures than Palacos R, with the 4 mu m IDX group having the lowest maximum temperature. The isothermal and the constant rate differential scanning calorimetry (DSC) did not show any difference in polymerisation heat (Delta H) or glass transition temperature (T-g) between radiolucent cement, or cement containing either IDX, or ZrO2. The findings show that the particle size for a bone cement containing iodixanol should be above 8 mu m MMD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Materials Science: Materials in Medicine
volume
18
pages
1043 - 1051
publisher
Kluwer
external identifiers
  • wos:000246618900010
  • scopus:34248995287
ISSN
1573-4838
DOI
10.1007/s10856-006-0116-8
language
English
LU publication?
yes
id
35596116-298d-4c48-a019-804b541da49b (old id 165990)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17265134&dopt=Abstract
date added to LUP
2007-07-12 12:13:41
date last changed
2017-01-01 06:56:58
@article{35596116-298d-4c48-a019-804b541da49b,
  abstract     = {Iodixanol (IDX) is a water soluble opacifier widely used in radiographical examinations of blood vessels and neural tissue, and it has been suggested as a potential contrast media in acrylic bone cement. The effect of the iodixanol particle size on the polymerisation process of the bone cement, the molecular weight, and the quasi-static mechanical properties have been investigated in this article. The investigation was performed using radiolucent Palacos powder mixed with 8 wt% of iodixanol with particle sizes ranging from 3 to 20 mu m MMD, compared with commercial Palacos R (15 wt% ZrO2) as control. Tensile, compressive and flexural tests showed that smaller particles (groups with 3, 4, and 5 mu m particles) resulted in significantly lower mechanical properties than the larger particles (groups with 15, 16, and 20 mu m particles). There was no difference in molecular weight between the groups. The thermographical investigation showed that the IDX cements exhibit substantially lower maximum temperatures than Palacos R, with the 4 mu m IDX group having the lowest maximum temperature. The isothermal and the constant rate differential scanning calorimetry (DSC) did not show any difference in polymerisation heat (Delta H) or glass transition temperature (T-g) between radiolucent cement, or cement containing either IDX, or ZrO2. The findings show that the particle size for a bone cement containing iodixanol should be above 8 mu m MMD.},
  author       = {Kjellson, Fred and Abdulghani, Saba and Tanner, K and McCarthy, Ian and Lidgren, Lars},
  issn         = {1573-4838},
  language     = {eng},
  pages        = {1043--1051},
  publisher    = {Kluwer},
  series       = {Journal of Materials Science: Materials in Medicine},
  title        = {Effect of iodixanol particle size on the mechanical properties of a PMMA based bone cement.},
  url          = {http://dx.doi.org/10.1007/s10856-006-0116-8},
  volume       = {18},
  year         = {2007},
}