Acute lymphoblastic leukemia
(2015) p.198-251- Abstract
Acute lymphoblastic leukemia (ALL) is classified as B-lineage ALL (B-ALL) and T-lineage ALL (T-ALL). The incidence of ALL is almost three times higher in white than black children. Among adults, ALL is more frequent in younger patients, with a median age of less than 30 years. The morphology-immunology-cytogenetics (MIC) subgroups are associated with nonrandom karyotypic abnormalities in a manner comparable to the specificity seen between chromosomal rearrangements and morphologic subgroups in acute myeloid leukemia. Low hyperdiploidy or hypodiploidy with 45 chromosomes and single numerical aberrations are increasingly being found as secondary changes associated with specific structural abnormalities. Cytogenetic analysis plays an... (More)
Acute lymphoblastic leukemia (ALL) is classified as B-lineage ALL (B-ALL) and T-lineage ALL (T-ALL). The incidence of ALL is almost three times higher in white than black children. Among adults, ALL is more frequent in younger patients, with a median age of less than 30 years. The morphology-immunology-cytogenetics (MIC) subgroups are associated with nonrandom karyotypic abnormalities in a manner comparable to the specificity seen between chromosomal rearrangements and morphologic subgroups in acute myeloid leukemia. Low hyperdiploidy or hypodiploidy with 45 chromosomes and single numerical aberrations are increasingly being found as secondary changes associated with specific structural abnormalities. Cytogenetic analysis plays an integral part in the diagnosis of ALL. The abnormalities differ between B-ALL and T-ALL with different distributions between age groups. In association with these aspects, the diagnostic karyotype is an important prognostic variable. Children with Down syndrome (DS) have a greatly increased risk of developing acute leukemia, including ALL.
(Less)
- author
- Harrison, Christine J. and Johansson, Bertil LU
- organization
- publishing date
- 2015
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Acute myeloid leukemia, B-lineage acute lymphoblastic leukemia, Cytogenetic analysis, Down syndrome, Karyotypic abnormalities, Low hyperdiploidy, T-lineage acute lymphoblastic leukemia
- host publication
- Cancer Cytogenetics : Chromosomal and Molecular Genetic Aberrations of Tumor Cells - Chromosomal and Molecular Genetic Aberrations of Tumor Cells
- editor
- Heim, Sverre and Mitelman, Felix
- edition
- 4th
- pages
- 54 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85015903787
- ISBN
- 9781118795569
- 9781118795538
- DOI
- 10.1002/9781118795569.ch10
- language
- English
- LU publication?
- yes
- id
- 166143ed-0a96-41c9-9c67-b8841b2ce6fd
- date added to LUP
- 2017-04-20 11:20:08
- date last changed
- 2024-04-28 11:00:38
@inbook{166143ed-0a96-41c9-9c67-b8841b2ce6fd,
abstract = {{<p>Acute lymphoblastic leukemia (ALL) is classified as B-lineage ALL (B-ALL) and T-lineage ALL (T-ALL). The incidence of ALL is almost three times higher in white than black children. Among adults, ALL is more frequent in younger patients, with a median age of less than 30 years. The morphology-immunology-cytogenetics (MIC) subgroups are associated with nonrandom karyotypic abnormalities in a manner comparable to the specificity seen between chromosomal rearrangements and morphologic subgroups in acute myeloid leukemia. Low hyperdiploidy or hypodiploidy with 45 chromosomes and single numerical aberrations are increasingly being found as secondary changes associated with specific structural abnormalities. Cytogenetic analysis plays an integral part in the diagnosis of ALL. The abnormalities differ between B-ALL and T-ALL with different distributions between age groups. In association with these aspects, the diagnostic karyotype is an important prognostic variable. Children with Down syndrome (DS) have a greatly increased risk of developing acute leukemia, including ALL.</p>}},
author = {{Harrison, Christine J. and Johansson, Bertil}},
booktitle = {{Cancer Cytogenetics : Chromosomal and Molecular Genetic Aberrations of Tumor Cells}},
editor = {{Heim, Sverre and Mitelman, Felix}},
isbn = {{9781118795569}},
keywords = {{Acute myeloid leukemia; B-lineage acute lymphoblastic leukemia; Cytogenetic analysis; Down syndrome; Karyotypic abnormalities; Low hyperdiploidy; T-lineage acute lymphoblastic leukemia}},
language = {{eng}},
pages = {{198--251}},
publisher = {{Wiley-Blackwell}},
title = {{Acute lymphoblastic leukemia}},
url = {{http://dx.doi.org/10.1002/9781118795569.ch10}},
doi = {{10.1002/9781118795569.ch10}},
year = {{2015}},
}