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Acute lymphoblastic leukemia

Harrison, Christine J. and Johansson, Bertil LU (2015) In Cancer Cytogenetics p.198-251
Abstract

Acute lymphoblastic leukemia (ALL) is classified as B-lineage ALL (B-ALL) and T-lineage ALL (T-ALL). The incidence of ALL is almost three times higher in white than black children. Among adults, ALL is more frequent in younger patients, with a median age of less than 30 years. The morphology-immunology-cytogenetics (MIC) subgroups are associated with nonrandom karyotypic abnormalities in a manner comparable to the specificity seen between chromosomal rearrangements and morphologic subgroups in acute myeloid leukemia. Low hyperdiploidy or hypodiploidy with 45 chromosomes and single numerical aberrations are increasingly being found as secondary changes associated with specific structural abnormalities. Cytogenetic analysis plays an... (More)

Acute lymphoblastic leukemia (ALL) is classified as B-lineage ALL (B-ALL) and T-lineage ALL (T-ALL). The incidence of ALL is almost three times higher in white than black children. Among adults, ALL is more frequent in younger patients, with a median age of less than 30 years. The morphology-immunology-cytogenetics (MIC) subgroups are associated with nonrandom karyotypic abnormalities in a manner comparable to the specificity seen between chromosomal rearrangements and morphologic subgroups in acute myeloid leukemia. Low hyperdiploidy or hypodiploidy with 45 chromosomes and single numerical aberrations are increasingly being found as secondary changes associated with specific structural abnormalities. Cytogenetic analysis plays an integral part in the diagnosis of ALL. The abnormalities differ between B-ALL and T-ALL with different distributions between age groups. In association with these aspects, the diagnostic karyotype is an important prognostic variable. Children with Down syndrome (DS) have a greatly increased risk of developing acute leukemia, including ALL.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acute myeloid leukemia, B-lineage acute lymphoblastic leukemia, Cytogenetic analysis, Down syndrome, Karyotypic abnormalities, Low hyperdiploidy, T-lineage acute lymphoblastic leukemia
in
Cancer Cytogenetics
editor
Heim, Sverre; Mitelman, Felix; and
pages
54 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85015903787
ISBN
9781118795538
9781118795569
DOI
10.1002/9781118795569.ch10
language
English
LU publication?
yes
id
166143ed-0a96-41c9-9c67-b8841b2ce6fd
date added to LUP
2017-04-20 11:20:08
date last changed
2017-10-01 05:33:26
@inbook{166143ed-0a96-41c9-9c67-b8841b2ce6fd,
  abstract     = {<p>Acute lymphoblastic leukemia (ALL) is classified as B-lineage ALL (B-ALL) and T-lineage ALL (T-ALL). The incidence of ALL is almost three times higher in white than black children. Among adults, ALL is more frequent in younger patients, with a median age of less than 30 years. The morphology-immunology-cytogenetics (MIC) subgroups are associated with nonrandom karyotypic abnormalities in a manner comparable to the specificity seen between chromosomal rearrangements and morphologic subgroups in acute myeloid leukemia. Low hyperdiploidy or hypodiploidy with 45 chromosomes and single numerical aberrations are increasingly being found as secondary changes associated with specific structural abnormalities. Cytogenetic analysis plays an integral part in the diagnosis of ALL. The abnormalities differ between B-ALL and T-ALL with different distributions between age groups. In association with these aspects, the diagnostic karyotype is an important prognostic variable. Children with Down syndrome (DS) have a greatly increased risk of developing acute leukemia, including ALL.</p>},
  author       = {Harrison, Christine J. and Johansson, Bertil},
  editor       = {Heim, Sverre and Mitelman, Felix},
  isbn         = {9781118795538},
  keyword      = {Acute myeloid leukemia,B-lineage acute lymphoblastic leukemia,Cytogenetic analysis,Down syndrome,Karyotypic abnormalities,Low hyperdiploidy,T-lineage acute lymphoblastic leukemia},
  language     = {eng},
  pages        = {198--251},
  publisher    = {Wiley-Blackwell},
  series       = {Cancer Cytogenetics},
  title        = {Acute lymphoblastic leukemia},
  url          = {http://dx.doi.org/10.1002/9781118795569.ch10},
  year         = {2015},
}