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Plasma Homocysteine Is Elevated in Elderly Patients with Memory Complaints and Vascular Disease.

Nilsson, Karin ; Gustafson, Lars LU and Hultberg, Björn LU (2007) In Dementia and Geriatric Cognitive Disorders 23(5). p.321-326
Abstract
Background: There is an association between elevated plasma total homocysteine (tHcy) and vascular disease in elderly patients suffering from organic and non-organic mental disease. The main objective of the present study was to investigate the relationship between plasma tHcy concentration and vascular disease in elderly patients with memory complaints. Methods: In 108 patients with memory complaints the concentration of plasma tHcy was related to the presence of vascular disease. Furthermore, different determinants of plasma tHcy concentration were measured. Results: Patients with confirmed memory complaints (CMC, n = 86) which fulfilled the criteria of mild cognitive impairment were divided into two categories, with and without vascular... (More)
Background: There is an association between elevated plasma total homocysteine (tHcy) and vascular disease in elderly patients suffering from organic and non-organic mental disease. The main objective of the present study was to investigate the relationship between plasma tHcy concentration and vascular disease in elderly patients with memory complaints. Methods: In 108 patients with memory complaints the concentration of plasma tHcy was related to the presence of vascular disease. Furthermore, different determinants of plasma tHcy concentration were measured. Results: Patients with confirmed memory complaints (CMC, n = 86) which fulfilled the criteria of mild cognitive impairment were divided into two categories, with and without vascular disease. The CMC group without vascular disease showed similar biochemical and brain imaging findings to patients with subjective memory complaints (SMC, n = 22). The group of CMC patients with vascular disease had higher age, higher plasma tHcy, lower serum folate and lower renal function than patients without vascular disease. Conclusion: The finding of two subgroups of patients with CMC supports the notion that mild cognitive impairment is a heterogenous clinical entity with multiple aetiological factors. The elevated plasma tHcy in the group of CMC patients with vascular disease is likely to be associated with vascular disease. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
vascular disease, memory complaints, homocysteine, folate, cobalamin, creatinine, cognitive impairment, mild
in
Dementia and Geriatric Cognitive Disorders
volume
23
issue
5
pages
321 - 326
publisher
Karger
external identifiers
  • wos:000245138100007
  • scopus:34247328566
  • pmid:17374950
ISSN
1420-8008
DOI
10.1159/000100927
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Division of Clinical Chemistry and Pharmacology (013250300)
id
05d5a49b-ec83-4bd6-84cb-49f0b22ef398 (old id 166313)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17374950&dopt=Abstract
date added to LUP
2016-04-01 11:35:14
date last changed
2022-01-26 07:20:39
@article{05d5a49b-ec83-4bd6-84cb-49f0b22ef398,
  abstract     = {{Background: There is an association between elevated plasma total homocysteine (tHcy) and vascular disease in elderly patients suffering from organic and non-organic mental disease. The main objective of the present study was to investigate the relationship between plasma tHcy concentration and vascular disease in elderly patients with memory complaints. Methods: In 108 patients with memory complaints the concentration of plasma tHcy was related to the presence of vascular disease. Furthermore, different determinants of plasma tHcy concentration were measured. Results: Patients with confirmed memory complaints (CMC, n = 86) which fulfilled the criteria of mild cognitive impairment were divided into two categories, with and without vascular disease. The CMC group without vascular disease showed similar biochemical and brain imaging findings to patients with subjective memory complaints (SMC, n = 22). The group of CMC patients with vascular disease had higher age, higher plasma tHcy, lower serum folate and lower renal function than patients without vascular disease. Conclusion: The finding of two subgroups of patients with CMC supports the notion that mild cognitive impairment is a heterogenous clinical entity with multiple aetiological factors. The elevated plasma tHcy in the group of CMC patients with vascular disease is likely to be associated with vascular disease.}},
  author       = {{Nilsson, Karin and Gustafson, Lars and Hultberg, Björn}},
  issn         = {{1420-8008}},
  keywords     = {{vascular disease; memory complaints; homocysteine; folate; cobalamin; creatinine; cognitive impairment; mild}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{321--326}},
  publisher    = {{Karger}},
  series       = {{Dementia and Geriatric Cognitive Disorders}},
  title        = {{Plasma Homocysteine Is Elevated in Elderly Patients with Memory Complaints and Vascular Disease.}},
  url          = {{http://dx.doi.org/10.1159/000100927}},
  doi          = {{10.1159/000100927}},
  volume       = {{23}},
  year         = {{2007}},
}