Advanced

Predicting cardiotoxicity propensity of the novel iodinated contrast medium GE-145: ventricular fibrillation during left coronary arteriography in pigs.

Chai, Chun-Ming LU ; Rasmussen, Henrik; Eriksen, Morten; Hvoslef, Anne-Marie; Evans, Paul; Newton, Ben B and Videm, Signe (2010) In Acta Radiologica 51. p.1007-1013
Abstract
Background: Severe side effects caused by iodinated radiographic contrast media (CM) are rare, but can occur in high risk patients and during percutaneous coronary intervention. To minimize this risk a new nonionic CM with low inherent osmolality has been designed, giving room for a relatively high concentration of favorable electrolytes in the isotonic formulation. Purpose: To test a new radiographic CM (GE-145) in a pig model of cardiotoxicity by comparing its ventricular fibrillation (VF) propensity and hemodynamic effects to that of iodixanol. Material and Methods: Test agents were injected into the left anterior descending coronary artery (LAD) of pigs through an inflated balloon catheter (injection volume 25 ml, injection rate 0.4... (More)
Background: Severe side effects caused by iodinated radiographic contrast media (CM) are rare, but can occur in high risk patients and during percutaneous coronary intervention. To minimize this risk a new nonionic CM with low inherent osmolality has been designed, giving room for a relatively high concentration of favorable electrolytes in the isotonic formulation. Purpose: To test a new radiographic CM (GE-145) in a pig model of cardiotoxicity by comparing its ventricular fibrillation (VF) propensity and hemodynamic effects to that of iodixanol. Material and Methods: Test agents were injected into the left anterior descending coronary artery (LAD) of pigs through an inflated balloon catheter (injection volume 25 ml, injection rate 0.4 ml/s, maximum injection time 62.5 s). Series 1: GE-145 (338 mg I/ml) + 45 mM NaCl and iodixanol (321 mg I/ml) + 19 mM NaCl were injected in five pigs. Series 2: GE-145 (320 mg I/ml) + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl(2) and iodixanol (320 mg I/ml) + 19 mM NaCl + 0.3 mM CaCl(2) (Visipaque) were injected in six pigs. Results: Iodixanol + NaCl caused VF in 6 of 13 injections (46%) after 60.3+/-7.5 s (mean +/- SD). GE-145 + NaCl did not cause any VF in 13 injections (0%) (P<0.05). Iodixanol + 19 mM NaCl + 0.3 mM CaCl(2) caused VF in 9 of 9 injections (100%) after 61+/-4 s. GE-145 + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl(2) did not cause any VF during or after 9 injections of each agent (0%) (P<0.05). The least hemodynamic effects were seen with GE-145 + 45 mM NaCl + 0.7 mM CaCl(2). Conclusion: In this model of direct administration of CM into the LAD of anesthetized pigs, the tested GE-145 formulations had a significantly lower propensity to induce VF than iodixanol with electrolytes. Favorable hemodynamic properties of GE-145 can be achieved by optimizing concentrations of sodium and calcium. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Radiologica
volume
51
pages
1007 - 1013
publisher
John Wiley & Sons
external identifiers
  • wos:000283058900009
  • pmid:20799918
  • scopus:77958030078
ISSN
1600-0455
DOI
10.3109/02841851.2010.504743
language
English
LU publication?
yes
id
bf497c31-99e5-49fc-a4bb-3b44756ccf64 (old id 1664960)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20799918?dopt=Abstract
date added to LUP
2010-09-14 09:52:25
date last changed
2018-05-29 12:19:13
@article{bf497c31-99e5-49fc-a4bb-3b44756ccf64,
  abstract     = {Background: Severe side effects caused by iodinated radiographic contrast media (CM) are rare, but can occur in high risk patients and during percutaneous coronary intervention. To minimize this risk a new nonionic CM with low inherent osmolality has been designed, giving room for a relatively high concentration of favorable electrolytes in the isotonic formulation. Purpose: To test a new radiographic CM (GE-145) in a pig model of cardiotoxicity by comparing its ventricular fibrillation (VF) propensity and hemodynamic effects to that of iodixanol. Material and Methods: Test agents were injected into the left anterior descending coronary artery (LAD) of pigs through an inflated balloon catheter (injection volume 25 ml, injection rate 0.4 ml/s, maximum injection time 62.5 s). Series 1: GE-145 (338 mg I/ml) + 45 mM NaCl and iodixanol (321 mg I/ml) + 19 mM NaCl were injected in five pigs. Series 2: GE-145 (320 mg I/ml) + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl(2) and iodixanol (320 mg I/ml) + 19 mM NaCl + 0.3 mM CaCl(2) (Visipaque) were injected in six pigs. Results: Iodixanol + NaCl caused VF in 6 of 13 injections (46%) after 60.3+/-7.5 s (mean +/- SD). GE-145 + NaCl did not cause any VF in 13 injections (0%) (P&lt;0.05). Iodixanol + 19 mM NaCl + 0.3 mM CaCl(2) caused VF in 9 of 9 injections (100%) after 61+/-4 s. GE-145 + 45 mM NaCl + 0.1, 0.3, or 0.7 mM CaCl(2) did not cause any VF during or after 9 injections of each agent (0%) (P&lt;0.05). The least hemodynamic effects were seen with GE-145 + 45 mM NaCl + 0.7 mM CaCl(2). Conclusion: In this model of direct administration of CM into the LAD of anesthetized pigs, the tested GE-145 formulations had a significantly lower propensity to induce VF than iodixanol with electrolytes. Favorable hemodynamic properties of GE-145 can be achieved by optimizing concentrations of sodium and calcium.},
  author       = {Chai, Chun-Ming and Rasmussen, Henrik and Eriksen, Morten and Hvoslef, Anne-Marie and Evans, Paul and Newton, Ben B and Videm, Signe},
  issn         = {1600-0455},
  language     = {eng},
  pages        = {1007--1013},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Predicting cardiotoxicity propensity of the novel iodinated contrast medium GE-145: ventricular fibrillation during left coronary arteriography in pigs.},
  url          = {http://dx.doi.org/10.3109/02841851.2010.504743},
  volume       = {51},
  year         = {2010},
}