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Plasma Homocysteine and Cognition in Elderly Patients with Dementia or Other Psychogeriatric Diseases.

Nilsson, Karin LU ; Gustafson, Lars LU and Hultberg, Björn LU (2010) In Dementia and Geriatric Cognitive Disorders 30(3). p.198-204
Abstract
Background: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentrations than patients without vascular disease. Increasing evidence indicates that vascular risk factors play a role in the development of cognitive impairment. Method: We have investigated the relation between plasma tHcy, its determinants and cognition, measured as MMSE, in 448 consecutively enrolled patients with dementia or other psychogeriatric diseases. Results: Multiple regression analyses showed that plasma tHcy was related to cognitive function in all patients as well as in demented and non-demented patients. The apparent close relationship between plasma... (More)
Background: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentrations than patients without vascular disease. Increasing evidence indicates that vascular risk factors play a role in the development of cognitive impairment. Method: We have investigated the relation between plasma tHcy, its determinants and cognition, measured as MMSE, in 448 consecutively enrolled patients with dementia or other psychogeriatric diseases. Results: Multiple regression analyses showed that plasma tHcy was related to cognitive function in all patients as well as in demented and non-demented patients. The apparent close relationship between plasma tHcy and cognition was mainly dependent on its determinant age, whereas the other determinants of plasma tHcy exhibited a limited influence on the relation between plasma tHcy and cognition. Plasma tHcy has its own, albeit modest, relationship to cognitive function (predictive value about 5%). Conclusion: Plasma tHcy itself seems to play a minor role in cognitive impairment in patients with dementia or other psychogeriatric diseases. When investigating the relation between plasma tHcy and cognition, it is important to consider the distribution of the main determinants of plasma tHcy and to correct plasma tHcy for these variables. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
30
issue
3
pages
198 - 204
publisher
Karger
external identifiers
  • wos:000281965800002
  • pmid:20798540
  • scopus:77956066614
  • pmid:20798540
ISSN
1420-8008
DOI
10.1159/000319535
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Division of Clinical Chemistry and Pharmacology (013250300)
id
f95faa95-4bb6-4848-b939-7e829cbc5c62 (old id 1664983)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20798540?dopt=Abstract
date added to LUP
2016-04-04 08:54:09
date last changed
2022-04-23 18:15:16
@article{f95faa95-4bb6-4848-b939-7e829cbc5c62,
  abstract     = {{Background: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentrations than patients without vascular disease. Increasing evidence indicates that vascular risk factors play a role in the development of cognitive impairment. Method: We have investigated the relation between plasma tHcy, its determinants and cognition, measured as MMSE, in 448 consecutively enrolled patients with dementia or other psychogeriatric diseases. Results: Multiple regression analyses showed that plasma tHcy was related to cognitive function in all patients as well as in demented and non-demented patients. The apparent close relationship between plasma tHcy and cognition was mainly dependent on its determinant age, whereas the other determinants of plasma tHcy exhibited a limited influence on the relation between plasma tHcy and cognition. Plasma tHcy has its own, albeit modest, relationship to cognitive function (predictive value about 5%). Conclusion: Plasma tHcy itself seems to play a minor role in cognitive impairment in patients with dementia or other psychogeriatric diseases. When investigating the relation between plasma tHcy and cognition, it is important to consider the distribution of the main determinants of plasma tHcy and to correct plasma tHcy for these variables.}},
  author       = {{Nilsson, Karin and Gustafson, Lars and Hultberg, Björn}},
  issn         = {{1420-8008}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{198--204}},
  publisher    = {{Karger}},
  series       = {{Dementia and Geriatric Cognitive Disorders}},
  title        = {{Plasma Homocysteine and Cognition in Elderly Patients with Dementia or Other Psychogeriatric Diseases.}},
  url          = {{http://dx.doi.org/10.1159/000319535}},
  doi          = {{10.1159/000319535}},
  volume       = {{30}},
  year         = {{2010}},
}