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Decreased aldosterone in the plasma of suicide attempters with major depressive disorder.

Hallberg, Ludvig LU ; Westrin, Åsa LU ; Isaksson, Anders LU ; Janelidze, Shorena LU ; Träskman Bendz, Lil LU and Brundin, Lena LU (2011) In Psychiatry Research 187. p.135-139
Abstract
Hormones and neurobiological factors may be regulated differently in suicidal versus non-suicidal depressive patients. There is currently limited knowledge about the relation of substances in the Renin-Angiotensin-Aldosterone system to depression and suicidality. We therefore investigated whether plasma levels of renin and aldosterone differ between suicide attempters, non-suicidal depressive patients and healthy controls. Furthermore, we analyzed the relation of renin and aldosterone to psychiatric symptoms in the patients. Suicidal patients with MDD, adjustment disorder and dysthymia, as well as two control groups consisting of non-suicidal MDD patients and healthy subjects, were rated using the Comprehensive Psychopathological Rating... (More)
Hormones and neurobiological factors may be regulated differently in suicidal versus non-suicidal depressive patients. There is currently limited knowledge about the relation of substances in the Renin-Angiotensin-Aldosterone system to depression and suicidality. We therefore investigated whether plasma levels of renin and aldosterone differ between suicide attempters, non-suicidal depressive patients and healthy controls. Furthermore, we analyzed the relation of renin and aldosterone to psychiatric symptoms in the patients. Suicidal patients with MDD, adjustment disorder and dysthymia, as well as two control groups consisting of non-suicidal MDD patients and healthy subjects, were rated using the Comprehensive Psychopathological Rating Scale (CPRS), including the Montgomery-Asberg Depression Rating Scale (MADRS) and the Brief Scale for Anxiety (BSA). Plasma samples were frozen immediately after collection and stored at -80 degrees C for 5-18years. Aldosterone and renin levels were analyzed using radioactive- and chemiluminescent immunoassays. We found that suicide attempters with MDD had significantly lower plasma levels of aldosterone than the other patient groups, as well as than the healthy controls. Moreover, increasing severity of psychiatric symptoms was associated with lower aldosterone levels in the suicide attempters with MDD. Non-suicidal patients with MDD did not differ significantly compared to healthy controls with respect to aldosterone and renin levels. These findings may indicate that low aldosterone levels could be a marker of suicidality in patients with MDD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Psychiatry Research
volume
187
pages
135 - 139
publisher
Elsevier
external identifiers
  • wos:000290183700023
  • pmid:20797799
  • scopus:79953123712
ISSN
1872-7123
DOI
10.1016/j.psychres.2010.07.038
language
English
LU publication?
yes
id
6412244c-30f5-4022-82dc-fc6ceaf03ae3 (old id 1664989)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20797799?dopt=Abstract
date added to LUP
2010-09-03 09:09:30
date last changed
2017-08-27 05:44:10
@article{6412244c-30f5-4022-82dc-fc6ceaf03ae3,
  abstract     = {Hormones and neurobiological factors may be regulated differently in suicidal versus non-suicidal depressive patients. There is currently limited knowledge about the relation of substances in the Renin-Angiotensin-Aldosterone system to depression and suicidality. We therefore investigated whether plasma levels of renin and aldosterone differ between suicide attempters, non-suicidal depressive patients and healthy controls. Furthermore, we analyzed the relation of renin and aldosterone to psychiatric symptoms in the patients. Suicidal patients with MDD, adjustment disorder and dysthymia, as well as two control groups consisting of non-suicidal MDD patients and healthy subjects, were rated using the Comprehensive Psychopathological Rating Scale (CPRS), including the Montgomery-Asberg Depression Rating Scale (MADRS) and the Brief Scale for Anxiety (BSA). Plasma samples were frozen immediately after collection and stored at -80 degrees C for 5-18years. Aldosterone and renin levels were analyzed using radioactive- and chemiluminescent immunoassays. We found that suicide attempters with MDD had significantly lower plasma levels of aldosterone than the other patient groups, as well as than the healthy controls. Moreover, increasing severity of psychiatric symptoms was associated with lower aldosterone levels in the suicide attempters with MDD. Non-suicidal patients with MDD did not differ significantly compared to healthy controls with respect to aldosterone and renin levels. These findings may indicate that low aldosterone levels could be a marker of suicidality in patients with MDD.},
  author       = {Hallberg, Ludvig and Westrin, Åsa and Isaksson, Anders and Janelidze, Shorena and Träskman Bendz, Lil and Brundin, Lena},
  issn         = {1872-7123},
  language     = {eng},
  pages        = {135--139},
  publisher    = {Elsevier},
  series       = {Psychiatry Research},
  title        = {Decreased aldosterone in the plasma of suicide attempters with major depressive disorder.},
  url          = {http://dx.doi.org/10.1016/j.psychres.2010.07.038},
  volume       = {187},
  year         = {2011},
}