Decreased aldosterone in the plasma of suicide attempters with major depressive disorder.
(2011) In Psychiatry Research 187. p.135-139- Abstract
- Hormones and neurobiological factors may be regulated differently in suicidal versus non-suicidal depressive patients. There is currently limited knowledge about the relation of substances in the Renin-Angiotensin-Aldosterone system to depression and suicidality. We therefore investigated whether plasma levels of renin and aldosterone differ between suicide attempters, non-suicidal depressive patients and healthy controls. Furthermore, we analyzed the relation of renin and aldosterone to psychiatric symptoms in the patients. Suicidal patients with MDD, adjustment disorder and dysthymia, as well as two control groups consisting of non-suicidal MDD patients and healthy subjects, were rated using the Comprehensive Psychopathological Rating... (More)
- Hormones and neurobiological factors may be regulated differently in suicidal versus non-suicidal depressive patients. There is currently limited knowledge about the relation of substances in the Renin-Angiotensin-Aldosterone system to depression and suicidality. We therefore investigated whether plasma levels of renin and aldosterone differ between suicide attempters, non-suicidal depressive patients and healthy controls. Furthermore, we analyzed the relation of renin and aldosterone to psychiatric symptoms in the patients. Suicidal patients with MDD, adjustment disorder and dysthymia, as well as two control groups consisting of non-suicidal MDD patients and healthy subjects, were rated using the Comprehensive Psychopathological Rating Scale (CPRS), including the Montgomery-Asberg Depression Rating Scale (MADRS) and the Brief Scale for Anxiety (BSA). Plasma samples were frozen immediately after collection and stored at -80 degrees C for 5-18years. Aldosterone and renin levels were analyzed using radioactive- and chemiluminescent immunoassays. We found that suicide attempters with MDD had significantly lower plasma levels of aldosterone than the other patient groups, as well as than the healthy controls. Moreover, increasing severity of psychiatric symptoms was associated with lower aldosterone levels in the suicide attempters with MDD. Non-suicidal patients with MDD did not differ significantly compared to healthy controls with respect to aldosterone and renin levels. These findings may indicate that low aldosterone levels could be a marker of suicidality in patients with MDD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1664989
- author
- Hallberg, Ludvig LU ; Westrin, Åsa LU ; Isaksson, Anders LU ; Janelidze, Shorena LU ; Träskman Bendz, Lil LU and Brundin, Lena LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Psychiatry Research
- volume
- 187
- pages
- 135 - 139
- publisher
- Elsevier
- external identifiers
-
- wos:000290183700023
- pmid:20797799
- scopus:79953123712
- pmid:20797799
- ISSN
- 1872-7123
- DOI
- 10.1016/j.psychres.2010.07.038
- language
- English
- LU publication?
- yes
- id
- 6412244c-30f5-4022-82dc-fc6ceaf03ae3 (old id 1664989)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20797799?dopt=Abstract
- date added to LUP
- 2016-04-04 07:56:57
- date last changed
- 2022-01-29 02:49:07
@article{6412244c-30f5-4022-82dc-fc6ceaf03ae3,
abstract = {{Hormones and neurobiological factors may be regulated differently in suicidal versus non-suicidal depressive patients. There is currently limited knowledge about the relation of substances in the Renin-Angiotensin-Aldosterone system to depression and suicidality. We therefore investigated whether plasma levels of renin and aldosterone differ between suicide attempters, non-suicidal depressive patients and healthy controls. Furthermore, we analyzed the relation of renin and aldosterone to psychiatric symptoms in the patients. Suicidal patients with MDD, adjustment disorder and dysthymia, as well as two control groups consisting of non-suicidal MDD patients and healthy subjects, were rated using the Comprehensive Psychopathological Rating Scale (CPRS), including the Montgomery-Asberg Depression Rating Scale (MADRS) and the Brief Scale for Anxiety (BSA). Plasma samples were frozen immediately after collection and stored at -80 degrees C for 5-18years. Aldosterone and renin levels were analyzed using radioactive- and chemiluminescent immunoassays. We found that suicide attempters with MDD had significantly lower plasma levels of aldosterone than the other patient groups, as well as than the healthy controls. Moreover, increasing severity of psychiatric symptoms was associated with lower aldosterone levels in the suicide attempters with MDD. Non-suicidal patients with MDD did not differ significantly compared to healthy controls with respect to aldosterone and renin levels. These findings may indicate that low aldosterone levels could be a marker of suicidality in patients with MDD.}},
author = {{Hallberg, Ludvig and Westrin, Åsa and Isaksson, Anders and Janelidze, Shorena and Träskman Bendz, Lil and Brundin, Lena}},
issn = {{1872-7123}},
language = {{eng}},
pages = {{135--139}},
publisher = {{Elsevier}},
series = {{Psychiatry Research}},
title = {{Decreased aldosterone in the plasma of suicide attempters with major depressive disorder.}},
url = {{http://dx.doi.org/10.1016/j.psychres.2010.07.038}},
doi = {{10.1016/j.psychres.2010.07.038}},
volume = {{187}},
year = {{2011}},
}