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The role of calcium in neutrophil granule-phagosome fusion.

Nordenfelt, Pontus LU and Tapper, Hans LU (2010) In Communicative & Integrative Biology 3(3). p.224-226
Abstract
During phagocytosis, neutrophils kill microorganisms by delivering antimicrobial substances to the phagosome. For this, the intracellular targeting and fusion of granules must be strictly regulated and a dependence on the cytosolic concentration of free calcium has been suggested. New evidence show that different mechanisms regulate early and late stages of Fc receptor-mediated phagocytosis. The early fusion events are dependent on calcium but this is not the case for the fusion of azurophilic granules with phagosomes at later stages. Certain pathogens target the granule-phagosome fusion machinery in order to survive intracellularly; a deeper understanding of intracellular membrane traffic processes could allow new approaches for the... (More)
During phagocytosis, neutrophils kill microorganisms by delivering antimicrobial substances to the phagosome. For this, the intracellular targeting and fusion of granules must be strictly regulated and a dependence on the cytosolic concentration of free calcium has been suggested. New evidence show that different mechanisms regulate early and late stages of Fc receptor-mediated phagocytosis. The early fusion events are dependent on calcium but this is not the case for the fusion of azurophilic granules with phagosomes at later stages. Certain pathogens target the granule-phagosome fusion machinery in order to survive intracellularly; a deeper understanding of intracellular membrane traffic processes could allow new approaches for the eradication of pathogens that are harbored inside the cells of our immune system. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Communicative & Integrative Biology
volume
3
issue
3
pages
224 - 226
publisher
Landes Bioscience
external identifiers
  • pmid:20714398
  • scopus:80054979292
ISSN
1942-0889
language
English
LU publication?
yes
id
3ffbd4ff-fb90-473b-9aea-a5f7963bf0b7 (old id 1665242)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20714398?dopt=Abstract
date added to LUP
2010-09-03 11:52:01
date last changed
2017-01-01 07:49:59
@article{3ffbd4ff-fb90-473b-9aea-a5f7963bf0b7,
  abstract     = {During phagocytosis, neutrophils kill microorganisms by delivering antimicrobial substances to the phagosome. For this, the intracellular targeting and fusion of granules must be strictly regulated and a dependence on the cytosolic concentration of free calcium has been suggested. New evidence show that different mechanisms regulate early and late stages of Fc receptor-mediated phagocytosis. The early fusion events are dependent on calcium but this is not the case for the fusion of azurophilic granules with phagosomes at later stages. Certain pathogens target the granule-phagosome fusion machinery in order to survive intracellularly; a deeper understanding of intracellular membrane traffic processes could allow new approaches for the eradication of pathogens that are harbored inside the cells of our immune system.},
  author       = {Nordenfelt, Pontus and Tapper, Hans},
  issn         = {1942-0889},
  language     = {eng},
  number       = {3},
  pages        = {224--226},
  publisher    = {Landes Bioscience},
  series       = {Communicative & Integrative Biology},
  title        = {The role of calcium in neutrophil granule-phagosome fusion.},
  volume       = {3},
  year         = {2010},
}