The impact of translocations and gene fusions on cancer causation.
Mitelman, Felix LU
; Johansson, Bertil
LU
and Mertens, Fredrik
LU
(2007)
In Nature Reviews. Cancer
7(4).
p.233-245
- Abstract
- Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions involving 337 different genes have been identified. An increasing number of gene fusions are being recognized as important diagnostic and prognostic parameters in malignant haematological disorders and childhood sarcomas. The biological and clinical impact of gene fusions in the more common solid tumour types has been less appreciated. However, an analysis of available data shows that gene fusions occur in all malignancies, and that they account for 20% of human cancer morbidity. With the advent of new and powerful investigative tools that enable the detection... (More)
- Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions involving 337 different genes have been identified. An increasing number of gene fusions are being recognized as important diagnostic and prognostic parameters in malignant haematological disorders and childhood sarcomas. The biological and clinical impact of gene fusions in the more common solid tumour types has been less appreciated. However, an analysis of available data shows that gene fusions occur in all malignancies, and that they account for 20% of human cancer morbidity. With the advent of new and powerful investigative tools that enable the detection of cytogenetically cryptic rearrangements, this proportion is likely to increase substantially. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/166533
- author
- Mitelman, Felix
LU
; Johansson, Bertil
LU
and Mertens, Fredrik
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Reviews. Cancer
- volume
- 7
- issue
- 4
- pages
- 233 - 245
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000245170000010
- scopus:33947581390
- ISSN
- 1474-1768
- DOI
- 10.1038/nrc2091
- language
- English
- LU publication?
- yes
- id
- 02026a8d-6be8-49bb-a435-27429c834bfd (old id 166533)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17361217&dopt=Abstract
- date added to LUP
- 2016-04-01 12:23:20
- date last changed
- 2022-06-09 17:41:43
@article{02026a8d-6be8-49bb-a435-27429c834bfd,
abstract = {{Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions involving 337 different genes have been identified. An increasing number of gene fusions are being recognized as important diagnostic and prognostic parameters in malignant haematological disorders and childhood sarcomas. The biological and clinical impact of gene fusions in the more common solid tumour types has been less appreciated. However, an analysis of available data shows that gene fusions occur in all malignancies, and that they account for 20% of human cancer morbidity. With the advent of new and powerful investigative tools that enable the detection of cytogenetically cryptic rearrangements, this proportion is likely to increase substantially.}},
author = {{Mitelman, Felix and Johansson, Bertil and Mertens, Fredrik}},
issn = {{1474-1768}},
language = {{eng}},
number = {{4}},
pages = {{233--245}},
publisher = {{Nature Publishing Group}},
series = {{Nature Reviews. Cancer}},
title = {{The impact of translocations and gene fusions on cancer causation.}},
url = {{http://dx.doi.org/10.1038/nrc2091}},
doi = {{10.1038/nrc2091}},
volume = {{7}},
year = {{2007}},
}