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The impact of translocations and gene fusions on cancer causation.

Mitelman, Felix LU ; Johansson, Bertil LU and Mertens, Fredrik LU (2007) In Nature Reviews. Cancer 7(4). p.233-245
Abstract
Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions involving 337 different genes have been identified. An increasing number of gene fusions are being recognized as important diagnostic and prognostic parameters in malignant haematological disorders and childhood sarcomas. The biological and clinical impact of gene fusions in the more common solid tumour types has been less appreciated. However, an analysis of available data shows that gene fusions occur in all malignancies, and that they account for 20% of human cancer morbidity. With the advent of new and powerful investigative tools that enable the detection... (More)
Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions involving 337 different genes have been identified. An increasing number of gene fusions are being recognized as important diagnostic and prognostic parameters in malignant haematological disorders and childhood sarcomas. The biological and clinical impact of gene fusions in the more common solid tumour types has been less appreciated. However, an analysis of available data shows that gene fusions occur in all malignancies, and that they account for 20% of human cancer morbidity. With the advent of new and powerful investigative tools that enable the detection of cytogenetically cryptic rearrangements, this proportion is likely to increase substantially. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews. Cancer
volume
7
issue
4
pages
233 - 245
publisher
Nature Publishing Group
external identifiers
  • wos:000245170000010
  • scopus:33947581390
ISSN
1474-1768
DOI
10.1038/nrc2091
language
English
LU publication?
yes
id
02026a8d-6be8-49bb-a435-27429c834bfd (old id 166533)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17361217&dopt=Abstract
date added to LUP
2007-07-09 08:09:47
date last changed
2017-11-05 03:44:46
@article{02026a8d-6be8-49bb-a435-27429c834bfd,
  abstract     = {Chromosome aberrations, in particular translocations and their corresponding gene fusions, have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions involving 337 different genes have been identified. An increasing number of gene fusions are being recognized as important diagnostic and prognostic parameters in malignant haematological disorders and childhood sarcomas. The biological and clinical impact of gene fusions in the more common solid tumour types has been less appreciated. However, an analysis of available data shows that gene fusions occur in all malignancies, and that they account for 20% of human cancer morbidity. With the advent of new and powerful investigative tools that enable the detection of cytogenetically cryptic rearrangements, this proportion is likely to increase substantially.},
  author       = {Mitelman, Felix and Johansson, Bertil and Mertens, Fredrik},
  issn         = {1474-1768},
  language     = {eng},
  number       = {4},
  pages        = {233--245},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews. Cancer},
  title        = {The impact of translocations and gene fusions on cancer causation.},
  url          = {http://dx.doi.org/10.1038/nrc2091},
  volume       = {7},
  year         = {2007},
}