Genetics of gestational diabetes mellitus.
Shaat, Nael LU
and Groop, Leif
LU
(2007)
In Current Medicinal Chemistry
14(5).
p.569-583
- Abstract
- About 2-5% of all pregnant women develop gestational diabetes mellitus (GDM) during their pregnancies and the prevalence has increased considerably during the last decade. GDM is a heterogeneous disorder that is defined as carbohydrate intolerance with onset or first recognition during pregnancy. It is manifested when pancreatic beta cells are no longer able to compensate for the increased insulin resistance during pregnancy, but the pathogenesis of the disease is still largely unknown. GDM is considered to result from interaction between genetic and environmental risk factors. Genetic predisposition to GDM has been suggested since GDM clusters in families. Also, women with mutations in MODY (Maturity onset diabetes of the young) genes... (More)
- About 2-5% of all pregnant women develop gestational diabetes mellitus (GDM) during their pregnancies and the prevalence has increased considerably during the last decade. GDM is a heterogeneous disorder that is defined as carbohydrate intolerance with onset or first recognition during pregnancy. It is manifested when pancreatic beta cells are no longer able to compensate for the increased insulin resistance during pregnancy, but the pathogenesis of the disease is still largely unknown. GDM is considered to result from interaction between genetic and environmental risk factors. Genetic predisposition to GDM has been suggested since GDM clusters in families. Also, women with mutations in MODY (Maturity onset diabetes of the young) genes often present with GDM. In addition, common variants in several candidate genes (e.g. potassium inwardly rectifying channel subfamily J, member 11 [KCNJ11], Glucokinase [GCK], Hepatocyte nuclear factor-1alpha [HNFIA] etc.) have been demonstrated to increase the risk of GDM. Old age, obesity and high fat diet represent some important non-genetic factors. There are several approaches to search for genes predisposing to a polygenic disease like GDM including linkage and association studies, expression profiling and animal models. A combination of several methods is usually necessary. Identification of the underlying genetic causes of GDM will eventually give a better view of the mechanisms that contribute to the pathophysiology of the disease, Furthermore, it may improve options to possibly prevent GDM and complications for the mother and her child. This review focuses on the genetics of GDM and possible implications in clinical practice. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/166735
- author
- Shaat, Nael
LU
and Groop, Leif
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ype 2 diabetes type 1 diabetes polymorphism MODY, gestational diabetes mellitus, genetics, association, GDM
- in
- Current Medicinal Chemistry
- volume
- 14
- issue
- 5
- pages
- 569 - 583
- publisher
- Bentham Science Publishers
- external identifiers
-
- wos:000244007600006
- scopus:33947582865
- ISSN
- 0929-8673
- DOI
- 10.2174/092986707780059643
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Diabetes and Endocrinology (013241530)
- id
- e7ad42fc-17fe-4dbd-bc3f-e893980da1b9 (old id 166735)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17346148&dopt=Abstract
- date added to LUP
- 2016-04-01 15:57:13
- date last changed
- 2024-04-11 16:03:17
@article{e7ad42fc-17fe-4dbd-bc3f-e893980da1b9,
abstract = {{About 2-5% of all pregnant women develop gestational diabetes mellitus (GDM) during their pregnancies and the prevalence has increased considerably during the last decade. GDM is a heterogeneous disorder that is defined as carbohydrate intolerance with onset or first recognition during pregnancy. It is manifested when pancreatic beta cells are no longer able to compensate for the increased insulin resistance during pregnancy, but the pathogenesis of the disease is still largely unknown. GDM is considered to result from interaction between genetic and environmental risk factors. Genetic predisposition to GDM has been suggested since GDM clusters in families. Also, women with mutations in MODY (Maturity onset diabetes of the young) genes often present with GDM. In addition, common variants in several candidate genes (e.g. potassium inwardly rectifying channel subfamily J, member 11 [KCNJ11], Glucokinase [GCK], Hepatocyte nuclear factor-1alpha [HNFIA] etc.) have been demonstrated to increase the risk of GDM. Old age, obesity and high fat diet represent some important non-genetic factors. There are several approaches to search for genes predisposing to a polygenic disease like GDM including linkage and association studies, expression profiling and animal models. A combination of several methods is usually necessary. Identification of the underlying genetic causes of GDM will eventually give a better view of the mechanisms that contribute to the pathophysiology of the disease, Furthermore, it may improve options to possibly prevent GDM and complications for the mother and her child. This review focuses on the genetics of GDM and possible implications in clinical practice.}},
author = {{Shaat, Nael and Groop, Leif}},
issn = {{0929-8673}},
keywords = {{ype 2 diabetes
type 1 diabetes
polymorphism
MODY; gestational diabetes mellitus; genetics; association; GDM}},
language = {{eng}},
number = {{5}},
pages = {{569--583}},
publisher = {{Bentham Science Publishers}},
series = {{Current Medicinal Chemistry}},
title = {{Genetics of gestational diabetes mellitus.}},
url = {{http://dx.doi.org/10.2174/092986707780059643}},
doi = {{10.2174/092986707780059643}},
volume = {{14}},
year = {{2007}},
}