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Glaucoma detection using different Stratus optical coherence tomography protocols.

Hougaard, Jesper LU ; Heijl, Anders LU and Bengtsson, Boel LU (2007) In Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00 85(Oct 19). p.251-256
Abstract
To examine and compare the diagnostic accuracy of retinal nerve fibre layer (RNFL) thickness measurements using different Stratus optical coherence tomography (OCT) scanning protocols. Stratus OCT data for 90 healthy subjects and 62 glaucoma patients with mild or moderate visual field loss were prospectively collected and analysed using four RNFL thickness protocols that differed in terms of image resolution and number of scans. Cut-off levels corrected for age and refractive error were defined by reference values derived from an independent normal database. Sensitivity and specificity were calculated for average RNFL thickness for the full circle scan, and for the quadrant and clock hour circle scan sectors at p < 5% and p < 1%... (More)
To examine and compare the diagnostic accuracy of retinal nerve fibre layer (RNFL) thickness measurements using different Stratus optical coherence tomography (OCT) scanning protocols. Stratus OCT data for 90 healthy subjects and 62 glaucoma patients with mild or moderate visual field loss were prospectively collected and analysed using four RNFL thickness protocols that differed in terms of image resolution and number of scans. Cut-off levels corrected for age and refractive error were defined by reference values derived from an independent normal database. Sensitivity and specificity were calculated for average RNFL thickness for the full circle scan, and for the quadrant and clock hour circle scan sectors at p < 5% and p < 1% cut-off values. Regular- and high-resolution images performed equally well, and single best-quality scans were as good as the average of three scans to distinguish between healthy and glaucomatous eyes. Full circle RNFL thickness yielded similar or better diagnostic accuracy than that of sectors. Sensitivities ranged from 84% to 87% and specificities from 89% to 93% for full circle RNFL thickness at the p < 5% cut-off level. The abilities of four different Stratus OCT RNFL thickness protocols to distinguish between eyes with predominantly mild glaucomatous field loss and healthy eyes were very similar. Thus diagnostic accuracy did not differ between high- and regular-resolution protocols, nor between global (full circle) and localized (sector) OCT parameters, which suggests a diffuse component in early glaucomatous RNFL damage. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glaucoma, layer, Stratus OCT, diagnosis, retinal nerve fibre, optical coherence tomography
in
Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00
volume
85
issue
Oct 19
pages
251 - 256
publisher
Wiley-Blackwell
external identifiers
  • wos:000246150700003
  • scopus:34248190263
ISSN
1395-3907
DOI
10.1111/j.1600-0420.2006.00826.x
language
English
LU publication?
yes
id
f320f0e0-453d-48ca-a200-b3a8eefa85fd (old id 166764)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17343690&dopt=Abstract
date added to LUP
2007-07-24 09:19:31
date last changed
2017-08-06 04:42:23
@article{f320f0e0-453d-48ca-a200-b3a8eefa85fd,
  abstract     = {To examine and compare the diagnostic accuracy of retinal nerve fibre layer (RNFL) thickness measurements using different Stratus optical coherence tomography (OCT) scanning protocols. Stratus OCT data for 90 healthy subjects and 62 glaucoma patients with mild or moderate visual field loss were prospectively collected and analysed using four RNFL thickness protocols that differed in terms of image resolution and number of scans. Cut-off levels corrected for age and refractive error were defined by reference values derived from an independent normal database. Sensitivity and specificity were calculated for average RNFL thickness for the full circle scan, and for the quadrant and clock hour circle scan sectors at p &lt; 5% and p &lt; 1% cut-off values. Regular- and high-resolution images performed equally well, and single best-quality scans were as good as the average of three scans to distinguish between healthy and glaucomatous eyes. Full circle RNFL thickness yielded similar or better diagnostic accuracy than that of sectors. Sensitivities ranged from 84% to 87% and specificities from 89% to 93% for full circle RNFL thickness at the p &lt; 5% cut-off level. The abilities of four different Stratus OCT RNFL thickness protocols to distinguish between eyes with predominantly mild glaucomatous field loss and healthy eyes were very similar. Thus diagnostic accuracy did not differ between high- and regular-resolution protocols, nor between global (full circle) and localized (sector) OCT parameters, which suggests a diffuse component in early glaucomatous RNFL damage.},
  author       = {Hougaard, Jesper and Heijl, Anders and Bengtsson, Boel},
  issn         = {1395-3907},
  keyword      = {glaucoma,layer,Stratus OCT,diagnosis,retinal nerve fibre,optical coherence tomography},
  language     = {eng},
  number       = {Oct 19},
  pages        = {251--256},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica Scandinavica1998-01-01+01:002008-01-01+01:00},
  title        = {Glaucoma detection using different Stratus optical coherence tomography protocols.},
  url          = {http://dx.doi.org/10.1111/j.1600-0420.2006.00826.x},
  volume       = {85},
  year         = {2007},
}