A novel approach to propagation pattern analysis in intracardiac atrial fibrillation signals
(2011) In Annals of Biomedical Engineering 39. p.310-323- Abstract
- The purpose of this study is to investigate propagation patterns in intracardiac signals recorded during atrial fibrillation (AF) using an approach based on partial directed coherence (PDC), which evaluates directional coupling between multiple signals in the frequency domain. The PDC is evaluated at the dominant frequency of AF signals and tested for significance using a surrogate data procedure specifically designed to assess causality. For significantly coupled sites, the approach allows also to estimate the delay in propagation. The methods potential is illustrated with two simulation scenarios based on a detailed ionic model of the human atrial myocyte as well as with real data recordings, selected to present typical propagation... (More)
- The purpose of this study is to investigate propagation patterns in intracardiac signals recorded during atrial fibrillation (AF) using an approach based on partial directed coherence (PDC), which evaluates directional coupling between multiple signals in the frequency domain. The PDC is evaluated at the dominant frequency of AF signals and tested for significance using a surrogate data procedure specifically designed to assess causality. For significantly coupled sites, the approach allows also to estimate the delay in propagation. The methods potential is illustrated with two simulation scenarios based on a detailed ionic model of the human atrial myocyte as well as with real data recordings, selected to present typical propagation mechanisms and recording situations in atrial tachyarrhythmias. In both simulation scenarios the significant PDCs correctly reflect the direction of coupling and thus the propagation between all recording sites. In the real data recordings, clear propagation patterns are identified which agree with previous clinical observations. Thus, the results illustrate the ability of the novel approach to identify propagation patterns from intracardiac signals during AF, which can provide important information about the underlying AF mechanisms, potentially improving the planning and outcome of arrhythmia ablation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1668142
- author
- Richter, Ulrike LU ; Faes, Luca ; Cristoforetti, Alessandro ; Masè, Michela ; Ravelli, Flavia ; Stridh, Martin LU and Sörnmo, Leif LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of Biomedical Engineering
- volume
- 39
- pages
- 310 - 323
- publisher
- Springer
- external identifiers
-
- wos:000287213100027
- scopus:78650868812
- pmid:20803171
- ISSN
- 1573-9686
- DOI
- 10.1007/s10439-010-0146-8
- language
- English
- LU publication?
- yes
- id
- 29f3c295-bd78-48c2-8724-b9b77e61c7ca (old id 1668142)
- date added to LUP
- 2016-04-01 11:14:36
- date last changed
- 2022-04-20 18:07:40
@article{29f3c295-bd78-48c2-8724-b9b77e61c7ca,
abstract = {{The purpose of this study is to investigate propagation patterns in intracardiac signals recorded during atrial fibrillation (AF) using an approach based on partial directed coherence (PDC), which evaluates directional coupling between multiple signals in the frequency domain. The PDC is evaluated at the dominant frequency of AF signals and tested for significance using a surrogate data procedure specifically designed to assess causality. For significantly coupled sites, the approach allows also to estimate the delay in propagation. The methods potential is illustrated with two simulation scenarios based on a detailed ionic model of the human atrial myocyte as well as with real data recordings, selected to present typical propagation mechanisms and recording situations in atrial tachyarrhythmias. In both simulation scenarios the significant PDCs correctly reflect the direction of coupling and thus the propagation between all recording sites. In the real data recordings, clear propagation patterns are identified which agree with previous clinical observations. Thus, the results illustrate the ability of the novel approach to identify propagation patterns from intracardiac signals during AF, which can provide important information about the underlying AF mechanisms, potentially improving the planning and outcome of arrhythmia ablation.}},
author = {{Richter, Ulrike and Faes, Luca and Cristoforetti, Alessandro and Masè, Michela and Ravelli, Flavia and Stridh, Martin and Sörnmo, Leif}},
issn = {{1573-9686}},
language = {{eng}},
pages = {{310--323}},
publisher = {{Springer}},
series = {{Annals of Biomedical Engineering}},
title = {{A novel approach to propagation pattern analysis in intracardiac atrial fibrillation signals}},
url = {{http://dx.doi.org/10.1007/s10439-010-0146-8}},
doi = {{10.1007/s10439-010-0146-8}},
volume = {{39}},
year = {{2011}},
}