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Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD.

Löfdahl, Claes-Göran LU ; Postma, D S; Pride, N B; Boe, J and Thorén, A (2007) In European Respiratory Journal 29(6). p.1115-1119
Abstract
Epidemiological studies have indicated that chronic obstructive pulmonary disease (COPD) may be associated with an increased incidence of ischaemic cardiac events. The current authors performed a post hoc analysis of the European Respiratory Society's study on Chronic Obstructive Pulmonary Disease (EUROSCOP); a 3-yr, placebo-controlled study of an inhaled corticosteroid budesonide 800 pg-day-1 in smokers (mean age 52 yrs) with mild COPD. The current study evaluates whether long-term budesonide treatment attenuates the incidence of ischaernic cardiac events, including angina pectorls, myocardial infarction, coronary artery disorder and myocardial ischaemia. Among the 1,175 patients evaluated for safety, 49 (4.2%) patients experienced 60... (More)
Epidemiological studies have indicated that chronic obstructive pulmonary disease (COPD) may be associated with an increased incidence of ischaemic cardiac events. The current authors performed a post hoc analysis of the European Respiratory Society's study on Chronic Obstructive Pulmonary Disease (EUROSCOP); a 3-yr, placebo-controlled study of an inhaled corticosteroid budesonide 800 pg-day-1 in smokers (mean age 52 yrs) with mild COPD. The current study evaluates whether long-term budesonide treatment attenuates the incidence of ischaernic cardiac events, including angina pectorls, myocardial infarction, coronary artery disorder and myocardial ischaemia. Among the 1,175 patients evaluated for safety, 49 (4.2%) patients experienced 60 ischaernic cardiac events. Patients treated with budesonide had a significantly lower incidence of ischaernic cardiac events (18 out of 593; 3.0%) than those receiving placebo (31 out of 582; 5.3%). The results of the present study support the hypothesis that treatment with inhaled budesonide reduces ischaernic cardiac events in patients with mild chronic obstructive pulmonary disease. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chronic obstructive pulmonary disease, ischaemic cardiac, events, budesonide
in
European Respiratory Journal
volume
29
issue
6
pages
1115 - 1119
publisher
Eur Respiratory Soc
external identifiers
  • wos:000247280500007
  • scopus:34250187100
ISSN
1399-3003
DOI
10.1183/09031936.00128806
language
English
LU publication?
yes
id
dc7ffb0d-d5a9-4cc5-9b87-4d79a962b6ba (old id 166897)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17331963&dopt=Abstract
date added to LUP
2007-07-11 12:05:53
date last changed
2017-10-01 03:53:47
@article{dc7ffb0d-d5a9-4cc5-9b87-4d79a962b6ba,
  abstract     = {Epidemiological studies have indicated that chronic obstructive pulmonary disease (COPD) may be associated with an increased incidence of ischaemic cardiac events. The current authors performed a post hoc analysis of the European Respiratory Society's study on Chronic Obstructive Pulmonary Disease (EUROSCOP); a 3-yr, placebo-controlled study of an inhaled corticosteroid budesonide 800 pg-day-1 in smokers (mean age 52 yrs) with mild COPD. The current study evaluates whether long-term budesonide treatment attenuates the incidence of ischaernic cardiac events, including angina pectorls, myocardial infarction, coronary artery disorder and myocardial ischaemia. Among the 1,175 patients evaluated for safety, 49 (4.2%) patients experienced 60 ischaernic cardiac events. Patients treated with budesonide had a significantly lower incidence of ischaernic cardiac events (18 out of 593; 3.0%) than those receiving placebo (31 out of 582; 5.3%). The results of the present study support the hypothesis that treatment with inhaled budesonide reduces ischaernic cardiac events in patients with mild chronic obstructive pulmonary disease.},
  author       = {Löfdahl, Claes-Göran and Postma, D S and Pride, N B and Boe, J and Thorén, A},
  issn         = {1399-3003},
  keyword      = {chronic obstructive pulmonary disease,ischaemic cardiac,events,budesonide},
  language     = {eng},
  number       = {6},
  pages        = {1115--1119},
  publisher    = {Eur Respiratory Soc},
  series       = {European Respiratory Journal},
  title        = {Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD.},
  url          = {http://dx.doi.org/10.1183/09031936.00128806},
  volume       = {29},
  year         = {2007},
}