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Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD.

Löfdahl, Claes-Göran LU ; Postma, D S ; Pride, N B ; Boe, J and Thorén, A (2007) In European Respiratory Journal 29(6). p.1115-1119
Abstract
Epidemiological studies have indicated that chronic obstructive pulmonary disease (COPD) may be associated with an increased incidence of ischaemic cardiac events. The current authors performed a post hoc analysis of the European Respiratory Society's study on Chronic Obstructive Pulmonary Disease (EUROSCOP); a 3-yr, placebo-controlled study of an inhaled corticosteroid budesonide 800 pg-day-1 in smokers (mean age 52 yrs) with mild COPD. The current study evaluates whether long-term budesonide treatment attenuates the incidence of ischaernic cardiac events, including angina pectorls, myocardial infarction, coronary artery disorder and myocardial ischaemia. Among the 1,175 patients evaluated for safety, 49 (4.2%) patients experienced 60... (More)
Epidemiological studies have indicated that chronic obstructive pulmonary disease (COPD) may be associated with an increased incidence of ischaemic cardiac events. The current authors performed a post hoc analysis of the European Respiratory Society's study on Chronic Obstructive Pulmonary Disease (EUROSCOP); a 3-yr, placebo-controlled study of an inhaled corticosteroid budesonide 800 pg-day-1 in smokers (mean age 52 yrs) with mild COPD. The current study evaluates whether long-term budesonide treatment attenuates the incidence of ischaernic cardiac events, including angina pectorls, myocardial infarction, coronary artery disorder and myocardial ischaemia. Among the 1,175 patients evaluated for safety, 49 (4.2%) patients experienced 60 ischaernic cardiac events. Patients treated with budesonide had a significantly lower incidence of ischaernic cardiac events (18 out of 593; 3.0%) than those receiving placebo (31 out of 582; 5.3%). The results of the present study support the hypothesis that treatment with inhaled budesonide reduces ischaernic cardiac events in patients with mild chronic obstructive pulmonary disease. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chronic obstructive pulmonary disease, ischaemic cardiac, events, budesonide
in
European Respiratory Journal
volume
29
issue
6
pages
1115 - 1119
publisher
European Respiratory Society
external identifiers
  • wos:000247280500007
  • scopus:34250187100
ISSN
1399-3003
DOI
10.1183/09031936.00128806
language
English
LU publication?
yes
id
dc7ffb0d-d5a9-4cc5-9b87-4d79a962b6ba (old id 166897)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17331963&dopt=Abstract
date added to LUP
2016-04-01 12:23:17
date last changed
2022-04-21 06:43:22
@article{dc7ffb0d-d5a9-4cc5-9b87-4d79a962b6ba,
  abstract     = {{Epidemiological studies have indicated that chronic obstructive pulmonary disease (COPD) may be associated with an increased incidence of ischaemic cardiac events. The current authors performed a post hoc analysis of the European Respiratory Society's study on Chronic Obstructive Pulmonary Disease (EUROSCOP); a 3-yr, placebo-controlled study of an inhaled corticosteroid budesonide 800 pg-day-1 in smokers (mean age 52 yrs) with mild COPD. The current study evaluates whether long-term budesonide treatment attenuates the incidence of ischaernic cardiac events, including angina pectorls, myocardial infarction, coronary artery disorder and myocardial ischaemia. Among the 1,175 patients evaluated for safety, 49 (4.2%) patients experienced 60 ischaernic cardiac events. Patients treated with budesonide had a significantly lower incidence of ischaernic cardiac events (18 out of 593; 3.0%) than those receiving placebo (31 out of 582; 5.3%). The results of the present study support the hypothesis that treatment with inhaled budesonide reduces ischaernic cardiac events in patients with mild chronic obstructive pulmonary disease.}},
  author       = {{Löfdahl, Claes-Göran and Postma, D S and Pride, N B and Boe, J and Thorén, A}},
  issn         = {{1399-3003}},
  keywords     = {{chronic obstructive pulmonary disease; ischaemic cardiac; events; budesonide}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1115--1119}},
  publisher    = {{European Respiratory Society}},
  series       = {{European Respiratory Journal}},
  title        = {{Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD.}},
  url          = {{http://dx.doi.org/10.1183/09031936.00128806}},
  doi          = {{10.1183/09031936.00128806}},
  volume       = {{29}},
  year         = {{2007}},
}