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Intracerebral regional distribution of blood flow in response to uterine contractions in growth-restricted human fetuses.

Fu, Jing LU and Olofsson, Per LU (2007) In Early Human Development 83(9). p.607-612
Abstract
Objective: To explore middle cerebral artery (MCA) and anterior cerebral artery (ACA) blood flow responses to superimposed acute hypoxemia in growth -restricted fetuses with and without established brain-sparing flow during basal conditions. Material and methods: 47 term fetuses suspected of growth restriction were exposed to an oxytocin challenge test with simultaneous cardiotocography and Doppler velocimetry in the umbilical artery, MCA and ACA. The MCA-to-ACA pulsatility index (PI) ratio was calculated during basal conditions, contractions and relaxations. Basal brain-sparing flow was defined as an MCA-to-umbilical artery PI ratio of <1.08, de novo brain-sparing flow in the MCA as an MCA PI decrease with I standard deviation during... (More)
Objective: To explore middle cerebral artery (MCA) and anterior cerebral artery (ACA) blood flow responses to superimposed acute hypoxemia in growth -restricted fetuses with and without established brain-sparing flow during basal conditions. Material and methods: 47 term fetuses suspected of growth restriction were exposed to an oxytocin challenge test with simultaneous cardiotocography and Doppler velocimetry in the umbilical artery, MCA and ACA. The MCA-to-ACA pulsatility index (PI) ratio was calculated during basal conditions, contractions and relaxations. Basal brain-sparing flow was defined as an MCA-to-umbilical artery PI ratio of <1.08, de novo brain-sparing flow in the MCA as an MCA PI decrease with I standard deviation during uterine contractions or relaxations compared with basal measurements, and de novo brain-sparing flow in the ACA as an ACA PI decrease with l standard deviation. Non-parametric statistical tests were used with P<0.05 considered significant. Results: MCA and ACA PI were both significantly tower in the brain-sparing flow group (N=8) during basal conditions (P <= 0.01). During the oxytocin challenge test, MCA and ACA PI both decreased in the non-brain -sparing flow group (N=39) (P <= 0.02) but not in the brain -sparing flow group (P >= 0.4). The MCA-to-ACA PI ratio remained unchanged in both groups. de novo brain-sparing flow calculations revealed no preferential flow to any cerebral artery. Conclusion: Cerebral circulatory responses to acute hypoxemia are synchronized in the middle and anterior cerebral arteries without any preferential regional flow distribution. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
middle cerebral artery, restriction, fetal growth, Doppler, anterior cerebral artery, brain-sparing, oxytocin challenge test, pregnancy
in
Early Human Development
volume
83
issue
9
pages
607 - 612
publisher
Elsevier
external identifiers
  • wos:000250369300010
  • scopus:34548487181
ISSN
1872-6232
DOI
10.1016/j.earlhumdev.2007.01.011
language
English
LU publication?
yes
id
c9929100-cd93-4e1e-8420-b0002b52127d (old id 166938)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17329044&dopt=Abstract
date added to LUP
2007-07-19 13:41:51
date last changed
2017-01-01 06:40:20
@article{c9929100-cd93-4e1e-8420-b0002b52127d,
  abstract     = {Objective: To explore middle cerebral artery (MCA) and anterior cerebral artery (ACA) blood flow responses to superimposed acute hypoxemia in growth -restricted fetuses with and without established brain-sparing flow during basal conditions. Material and methods: 47 term fetuses suspected of growth restriction were exposed to an oxytocin challenge test with simultaneous cardiotocography and Doppler velocimetry in the umbilical artery, MCA and ACA. The MCA-to-ACA pulsatility index (PI) ratio was calculated during basal conditions, contractions and relaxations. Basal brain-sparing flow was defined as an MCA-to-umbilical artery PI ratio of &lt;1.08, de novo brain-sparing flow in the MCA as an MCA PI decrease with I standard deviation during uterine contractions or relaxations compared with basal measurements, and de novo brain-sparing flow in the ACA as an ACA PI decrease with l standard deviation. Non-parametric statistical tests were used with P&lt;0.05 considered significant. Results: MCA and ACA PI were both significantly tower in the brain-sparing flow group (N=8) during basal conditions (P &lt;= 0.01). During the oxytocin challenge test, MCA and ACA PI both decreased in the non-brain -sparing flow group (N=39) (P &lt;= 0.02) but not in the brain -sparing flow group (P &gt;= 0.4). The MCA-to-ACA PI ratio remained unchanged in both groups. de novo brain-sparing flow calculations revealed no preferential flow to any cerebral artery. Conclusion: Cerebral circulatory responses to acute hypoxemia are synchronized in the middle and anterior cerebral arteries without any preferential regional flow distribution.},
  author       = {Fu, Jing and Olofsson, Per},
  issn         = {1872-6232},
  keyword      = {middle cerebral artery,restriction,fetal growth,Doppler,anterior cerebral artery,brain-sparing,oxytocin challenge test,pregnancy},
  language     = {eng},
  number       = {9},
  pages        = {607--612},
  publisher    = {Elsevier},
  series       = {Early Human Development},
  title        = {Intracerebral regional distribution of blood flow in response to uterine contractions in growth-restricted human fetuses.},
  url          = {http://dx.doi.org/10.1016/j.earlhumdev.2007.01.011},
  volume       = {83},
  year         = {2007},
}