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Construction of a Pre-Clinical High Resolution Tomographic Scintillation Camera System

Peterson, Mikael LU ; Ljunggren, Kaj LU ; Palmer, John LU ; Strand, Sven-Erik LU and Miller, Brian (2009) IEEE Nuclear Science Symposium Conference 2009 In 2009 IEEE Nuclear Science Symposium Conference Record, Vols 1-5 p.3670-3671
Abstract
We are constructing a High Resolution Tomographic Scintillation Camera System for small animal imaging. The system consists of a CsI(Tl) scintillator coupled to a military surplus image intensifier with a CCD camera focused on the output window. The system operates in photons counting mode and the spatial resolution is improved by centroid calculations for every photon interaction. The system can be mounted on an optical rail together with a pinhole collimator and a rotating table. A hot rod phantom was filled with Tl-201 or Tc-99m solute and imaged. The phantom rod diameters range from 1.1 to 1.6 mm. 64 projections were acquired (300 s/projection) with 1 mm pinhole insert. Data was reconstructed using an OSEM algorithm. Image data was... (More)
We are constructing a High Resolution Tomographic Scintillation Camera System for small animal imaging. The system consists of a CsI(Tl) scintillator coupled to a military surplus image intensifier with a CCD camera focused on the output window. The system operates in photons counting mode and the spatial resolution is improved by centroid calculations for every photon interaction. The system can be mounted on an optical rail together with a pinhole collimator and a rotating table. A hot rod phantom was filled with Tl-201 or Tc-99m solute and imaged. The phantom rod diameters range from 1.1 to 1.6 mm. 64 projections were acquired (300 s/projection) with 1 mm pinhole insert. Data was reconstructed using an OSEM algorithm. Image data was corrected for decay, position non-linearities in image intensifier and the angular dependence of the pinhole. The reconstructed resolution is 13 mm (by visual inspection) for both Tc-99m and Tl-201. Higher spatial resolution is achievable with smaller pinhole diameters. Future work includes optimizing spatial resolution and sensitivity of a single system using analytical calculations, experiments and simulations. With the conclusions drawn from those calculations we plan to construct a multi-camera system. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
single photon imaging, component, small animal SPECT, molecular imaging
in
2009 IEEE Nuclear Science Symposium Conference Record, Vols 1-5
pages
3670 - 3671
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
conference name
IEEE Nuclear Science Symposium Conference 2009
external identifiers
  • wos:000280505102063
  • scopus:77951194857
ISSN
1082-3654
language
English
LU publication?
yes
id
5b6a6f2b-9ef1-4bd5-af02-00a645360e80 (old id 1672091)
date added to LUP
2010-09-21 12:24:52
date last changed
2017-01-01 05:43:35
@inproceedings{5b6a6f2b-9ef1-4bd5-af02-00a645360e80,
  abstract     = {We are constructing a High Resolution Tomographic Scintillation Camera System for small animal imaging. The system consists of a CsI(Tl) scintillator coupled to a military surplus image intensifier with a CCD camera focused on the output window. The system operates in photons counting mode and the spatial resolution is improved by centroid calculations for every photon interaction. The system can be mounted on an optical rail together with a pinhole collimator and a rotating table. A hot rod phantom was filled with Tl-201 or Tc-99m solute and imaged. The phantom rod diameters range from 1.1 to 1.6 mm. 64 projections were acquired (300 s/projection) with 1 mm pinhole insert. Data was reconstructed using an OSEM algorithm. Image data was corrected for decay, position non-linearities in image intensifier and the angular dependence of the pinhole. The reconstructed resolution is 13 mm (by visual inspection) for both Tc-99m and Tl-201. Higher spatial resolution is achievable with smaller pinhole diameters. Future work includes optimizing spatial resolution and sensitivity of a single system using analytical calculations, experiments and simulations. With the conclusions drawn from those calculations we plan to construct a multi-camera system.},
  author       = {Peterson, Mikael and Ljunggren, Kaj and Palmer, John and Strand, Sven-Erik and Miller, Brian},
  booktitle    = {2009 IEEE Nuclear Science Symposium Conference Record, Vols 1-5},
  issn         = {1082-3654},
  keyword      = {single photon imaging,component,small animal SPECT,molecular imaging},
  language     = {eng},
  pages        = {3670--3671},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  title        = {Construction of a Pre-Clinical High Resolution Tomographic Scintillation Camera System},
  year         = {2009},
}