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Diabetes, prediabetes and cancer mortality

Zhou, X. H.; Qiao, Q.; Zethelius, B.; Pyorala, K.; Soderberg, S.; Pajak, A.; Stehouwer, C. D. A.; Heine, R. J.; Jousilahti, P. and Ruotolo, G., et al. (2010) In Diabetologia 53(9). p.1867-1876
Abstract
Aims/hypothesis We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT. Methods Data from 17 European population-based or occupational cohorts involved in the DECODE study comprising 26,460 men and 18,195 women aged 25-90 years were collaboratively analysed. The cohorts were recruited between 1966 and 2004 and followed for 5.9 to 36.8 years. Cox proportional hazards analysis with adjustment for cohort, age, BMI, total cholesterol, blood pressure and smoking status was used to estimate HRs for cancer mortality. Results Compared with people in the normal glucose category, multivariable adjusted HRs (95% CI) for cancer mortality were 1.13 (1.00, 1.28), 1.27 (1.02,... (More)
Aims/hypothesis We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT. Methods Data from 17 European population-based or occupational cohorts involved in the DECODE study comprising 26,460 men and 18,195 women aged 25-90 years were collaboratively analysed. The cohorts were recruited between 1966 and 2004 and followed for 5.9 to 36.8 years. Cox proportional hazards analysis with adjustment for cohort, age, BMI, total cholesterol, blood pressure and smoking status was used to estimate HRs for cancer mortality. Results Compared with people in the normal glucose category, multivariable adjusted HRs (95% CI) for cancer mortality were 1.13 (1.00, 1.28), 1.27 (1.02, 1.57) and 1.71 (1.35, 2.17) in men with prediabetes, previously undiagnosed diabetes and known diabetes, respectively; in women they were 1.11 (0.94, 1.30), 1.31 (1.00, 1.70) and 1.43 (1.01, 2.02), respectively. Significant increases in deaths from cancer of the stomach, colon-rectum and liver in men with prediabetes and diabetes, and deaths from cancers of the liver and pancreas in women with diabetes were also observed. In individuals without known diabetes, the HR (95% CI) for cancer mortality corresponding to a one standard deviation increase in fasting plasma glucose was 1.06 (1.02, 1.09) and in 2 h plasma glucose was 1.07 (1.03, 1.11). Conclusions/interpretation Diabetes and prediabetes were associated with an increased risk of cancer death, particularly death from liver cancer. Mortality from all cancers rose linearly with increasing glucose concentrations. (Less)
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Contribution to journal
publication status
published
subject
keywords
Mortality, Cancer, Diabetes
in
Diabetologia
volume
53
issue
9
pages
1867 - 1876
publisher
Springer Verlag
external identifiers
  • wos:000281012200009
  • scopus:77955560604
ISSN
1432-0428
DOI
10.1007/s00125-010-1796-7
language
English
LU publication?
yes
id
990efd92-dcdf-4fe3-8ada-2c3444c6c091 (old id 1673893)
date added to LUP
2010-12-23 10:18:57
date last changed
2018-06-17 03:01:22
@article{990efd92-dcdf-4fe3-8ada-2c3444c6c091,
  abstract     = {Aims/hypothesis We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT. Methods Data from 17 European population-based or occupational cohorts involved in the DECODE study comprising 26,460 men and 18,195 women aged 25-90 years were collaboratively analysed. The cohorts were recruited between 1966 and 2004 and followed for 5.9 to 36.8 years. Cox proportional hazards analysis with adjustment for cohort, age, BMI, total cholesterol, blood pressure and smoking status was used to estimate HRs for cancer mortality. Results Compared with people in the normal glucose category, multivariable adjusted HRs (95% CI) for cancer mortality were 1.13 (1.00, 1.28), 1.27 (1.02, 1.57) and 1.71 (1.35, 2.17) in men with prediabetes, previously undiagnosed diabetes and known diabetes, respectively; in women they were 1.11 (0.94, 1.30), 1.31 (1.00, 1.70) and 1.43 (1.01, 2.02), respectively. Significant increases in deaths from cancer of the stomach, colon-rectum and liver in men with prediabetes and diabetes, and deaths from cancers of the liver and pancreas in women with diabetes were also observed. In individuals without known diabetes, the HR (95% CI) for cancer mortality corresponding to a one standard deviation increase in fasting plasma glucose was 1.06 (1.02, 1.09) and in 2 h plasma glucose was 1.07 (1.03, 1.11). Conclusions/interpretation Diabetes and prediabetes were associated with an increased risk of cancer death, particularly death from liver cancer. Mortality from all cancers rose linearly with increasing glucose concentrations.},
  author       = {Zhou, X. H. and Qiao, Q. and Zethelius, B. and Pyorala, K. and Soderberg, S. and Pajak, A. and Stehouwer, C. D. A. and Heine, R. J. and Jousilahti, P. and Ruotolo, G. and Nilsson, Peter and Calori, G. and Tuomilehto, J.},
  issn         = {1432-0428},
  keyword      = {Mortality,Cancer,Diabetes},
  language     = {eng},
  number       = {9},
  pages        = {1867--1876},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Diabetes, prediabetes and cancer mortality},
  url          = {http://dx.doi.org/10.1007/s00125-010-1796-7},
  volume       = {53},
  year         = {2010},
}