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Quantitative Risk Assessment of Contact Sensitization: Clinical Data to Assess Utility of the Model

Api, Anne Marie; Belsito, Donald; Bickers, David; Bruze, Magnus LU ; Calow, Peter; Greim, Helmut; Hanifin, Jon M.; McNamee, Pauline M.; Rogers, Adrianne E. and Saurat, Jean-Hilaire, et al. (2010) In Dermatitis 21(4). p.207-213
Abstract
Background: Contact hypersensitivity quantitative risk assessment (QRA) for fragrance ingredients is being used to establish new international standards for all fragrance ingredients that are potential skin sensitizers. Objective: The objective was to evaluate the retrospective clinical data on three fragrance ingredients in order to provide a practical assessment of the predictive value of the QRA approach. It is important to have data to assess that the methodology provides a robust approach for primary prevention of contact sensitization induction for fragrance ingredients identified as potential sensitizers. Methods: This article reviews clinical data for three fragrance ingredients cinnamic aldehyde, citral, and isoeugenol to assess... (More)
Background: Contact hypersensitivity quantitative risk assessment (QRA) for fragrance ingredients is being used to establish new international standards for all fragrance ingredients that are potential skin sensitizers. Objective: The objective was to evaluate the retrospective clinical data on three fragrance ingredients in order to provide a practical assessment of the predictive value of the QRA approach. It is important to have data to assess that the methodology provides a robust approach for primary prevention of contact sensitization induction for fragrance ingredients identified as potential sensitizers. Methods: This article reviews clinical data for three fragrance ingredients cinnamic aldehyde, citral, and isoeugenol to assess the utility of the QRA approach for fragrance ingredients. Results: This assessment suggests that had the QRA approach been available at the time standards were established for these fragrance ingredients, the clinical response might have been noticeably improved. Prospectively, with the establishment of QRA-derived standards, there should be a continued downward trend in patch test-positive rates for cinnamic aldehyde, citral, and isoeugenol over time. Conclusion: While it is recognized that the availability of retrospective data is limited, a longitudinal review of these data gives confidence that the QRA approach should be an effective tool for primary prevention. This study also highlights the importance of continued active monitoring of clinical patch-test data for fragrance ingredients. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dermatitis
volume
21
issue
4
pages
207 - 213
publisher
BC Decker
external identifiers
  • wos:000280895100004
  • scopus:77955113611
ISSN
1532-8163
DOI
10.2310/6620.2010.10032
language
English
LU publication?
yes
id
0e6cf2f2-0566-418e-ba10-0fba9f9b21d4 (old id 1673921)
date added to LUP
2010-09-22 15:05:35
date last changed
2018-05-29 12:30:54
@article{0e6cf2f2-0566-418e-ba10-0fba9f9b21d4,
  abstract     = {Background: Contact hypersensitivity quantitative risk assessment (QRA) for fragrance ingredients is being used to establish new international standards for all fragrance ingredients that are potential skin sensitizers. Objective: The objective was to evaluate the retrospective clinical data on three fragrance ingredients in order to provide a practical assessment of the predictive value of the QRA approach. It is important to have data to assess that the methodology provides a robust approach for primary prevention of contact sensitization induction for fragrance ingredients identified as potential sensitizers. Methods: This article reviews clinical data for three fragrance ingredients cinnamic aldehyde, citral, and isoeugenol to assess the utility of the QRA approach for fragrance ingredients. Results: This assessment suggests that had the QRA approach been available at the time standards were established for these fragrance ingredients, the clinical response might have been noticeably improved. Prospectively, with the establishment of QRA-derived standards, there should be a continued downward trend in patch test-positive rates for cinnamic aldehyde, citral, and isoeugenol over time. Conclusion: While it is recognized that the availability of retrospective data is limited, a longitudinal review of these data gives confidence that the QRA approach should be an effective tool for primary prevention. This study also highlights the importance of continued active monitoring of clinical patch-test data for fragrance ingredients.},
  author       = {Api, Anne Marie and Belsito, Donald and Bickers, David and Bruze, Magnus and Calow, Peter and Greim, Helmut and Hanifin, Jon M. and McNamee, Pauline M. and Rogers, Adrianne E. and Saurat, Jean-Hilaire and Sipes, I. Glenn and Tagami, Hachiro},
  issn         = {1532-8163},
  language     = {eng},
  number       = {4},
  pages        = {207--213},
  publisher    = {BC Decker},
  series       = {Dermatitis},
  title        = {Quantitative Risk Assessment of Contact Sensitization: Clinical Data to Assess Utility of the Model},
  url          = {http://dx.doi.org/10.2310/6620.2010.10032},
  volume       = {21},
  year         = {2010},
}