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Recommendation of appropriate amounts of petrolatum preparation to be applied at patch testing.

Bruze, Magnus LU ; Isaksson, Marléne LU ; Gruvberger, Birgitta LU and Frick-Engfeldt, Malin (2007) In Contact Dermatitis 56(5). p.281-285
Abstract
Background: No recommendation exists on the amount of petrolatum (pet.) preparation to be applied in a Finn Chamber (R) or van der Bend Chamber. Objectives: The aim of this study was to determine the appropriate amount of pet. preparation to apply in the Finn and van der Bend chambers. Methods: 12 volunteers were patch tested with green-coloured pet. in Finn and van der Bend chambers on the back on 3 occasions. Doses were 10, 15, 20, 25, and 30 mg initially and on second and third occasion, 10 mg was removed in van der Bend Chambers and 35 mg was added. On day 2, the test sites were scored. A negative test equalled a test area not covered to 100%. A positive test meant a completely green-coloured test area. Minor and major spreading was... (More)
Background: No recommendation exists on the amount of petrolatum (pet.) preparation to be applied in a Finn Chamber (R) or van der Bend Chamber. Objectives: The aim of this study was to determine the appropriate amount of pet. preparation to apply in the Finn and van der Bend chambers. Methods: 12 volunteers were patch tested with green-coloured pet. in Finn and van der Bend chambers on the back on 3 occasions. Doses were 10, 15, 20, 25, and 30 mg initially and on second and third occasion, 10 mg was removed in van der Bend Chambers and 35 mg was added. On day 2, the test sites were scored. A negative test equalled a test area not covered to 100%. A positive test meant a completely green-coloured test area. Minor and major spreading was noted. The amount of pet. preparation yielding at most 5% negative reactions and having the least number of reactions with major spreading equalled the appropriate amount. Results: For van der Bend Chambers, all doses yielded more than 5% negative reactions. For the Finn Chamber (R), 30, 25, and 20 mg pet. yielded less than 5% negative reactions and with major spreading in 60%, 40%, and 25% of test sites. Conclusions: 20 mg pet. preparation was the optimal dose for the Finn Chambers (R). (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
different doses, appropriate amount, Finn Chambers (R), petrolatum test, preparations, van der Bend Chambers
in
Contact Dermatitis
volume
56
issue
5
pages
281 - 285
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000245692800008
  • scopus:34247237322
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2007.01098.x
language
English
LU publication?
yes
id
bf8bd5c8-0b8b-4141-a8e8-e3fff4c30555 (old id 167537)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17441852&dopt=Abstract
date added to LUP
2007-07-16 14:43:36
date last changed
2017-11-05 03:47:52
@article{bf8bd5c8-0b8b-4141-a8e8-e3fff4c30555,
  abstract     = {Background: No recommendation exists on the amount of petrolatum (pet.) preparation to be applied in a Finn Chamber (R) or van der Bend Chamber. Objectives: The aim of this study was to determine the appropriate amount of pet. preparation to apply in the Finn and van der Bend chambers. Methods: 12 volunteers were patch tested with green-coloured pet. in Finn and van der Bend chambers on the back on 3 occasions. Doses were 10, 15, 20, 25, and 30 mg initially and on second and third occasion, 10 mg was removed in van der Bend Chambers and 35 mg was added. On day 2, the test sites were scored. A negative test equalled a test area not covered to 100%. A positive test meant a completely green-coloured test area. Minor and major spreading was noted. The amount of pet. preparation yielding at most 5% negative reactions and having the least number of reactions with major spreading equalled the appropriate amount. Results: For van der Bend Chambers, all doses yielded more than 5% negative reactions. For the Finn Chamber (R), 30, 25, and 20 mg pet. yielded less than 5% negative reactions and with major spreading in 60%, 40%, and 25% of test sites. Conclusions: 20 mg pet. preparation was the optimal dose for the Finn Chambers (R).},
  author       = {Bruze, Magnus and Isaksson, Marléne and Gruvberger, Birgitta and Frick-Engfeldt, Malin},
  issn         = {0105-1873},
  keyword      = {different doses,appropriate amount,Finn Chambers (R),petrolatum test,preparations,van der Bend Chambers},
  language     = {eng},
  number       = {5},
  pages        = {281--285},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Recommendation of appropriate amounts of petrolatum preparation to be applied at patch testing.},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2007.01098.x},
  volume       = {56},
  year         = {2007},
}