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Contact dermatitis to a rubber allergen with both dithiocarbamate and benzothiazole structure.

Bergendorff, Ola LU and Hansson, Christer LU (2007) In Contact Dermatitis 56(5). p.278-280
Abstract
Contact dermatitis to rubber products are often caused by additives used during manufacture, and diagnosed from patch test with established rubber allergen series. In these series the compounds are divided into separate groups such as thiurams, dithiocarbamates and mercaptobenzothiazoles. The objectives were to investigate the substances with allergenic structures present in a diving mask giving rise to facial dermatitis, also those substances including structures from different groups of rubber chemicals. The rubber material was analysed by high-performance liquid chromatography and diode-array detector. The patient was tested by epicutaneous tests using pure substances, extracts and authentic rubber material.... (More)
Contact dermatitis to rubber products are often caused by additives used during manufacture, and diagnosed from patch test with established rubber allergen series. In these series the compounds are divided into separate groups such as thiurams, dithiocarbamates and mercaptobenzothiazoles. The objectives were to investigate the substances with allergenic structures present in a diving mask giving rise to facial dermatitis, also those substances including structures from different groups of rubber chemicals. The rubber material was analysed by high-performance liquid chromatography and diode-array detector. The patient was tested by epicutaneous tests using pure substances, extracts and authentic rubber material. 2-Benzothiazolyl-N,N-diethylthiocarbamylsulfide, was found in the diving mask and the patient showed positive reaction to the pure compound and to extracts of the diving mask. This compound has structures of both mercaptobenzothiazole and thiuram/dithiocarbamate in its formulae. Besides the established groups of rubber accelerators, uncommon allergens with structures from more than one group can be formed or added at vulcanization. Chemical analysis of the product is needed to find these allergens. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
eczema, diethyldithiocarbamate, mercaptobenzothiazole, rubber, vulcanization
in
Contact Dermatitis
volume
56
issue
5
pages
278 - 280
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000245692800007
  • scopus:34247192085
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2007.01076.x
language
English
LU publication?
yes
id
b4f91583-7678-4322-95a4-a79b576d65d1 (old id 167543)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17441851&dopt=Abstract
date added to LUP
2007-07-12 08:58:55
date last changed
2017-04-30 09:25:00
@article{b4f91583-7678-4322-95a4-a79b576d65d1,
  abstract     = {Contact dermatitis to rubber products are often caused by additives used during manufacture, and diagnosed from patch test with established rubber allergen series. In these series the compounds are divided into separate groups such as thiurams, dithiocarbamates and mercaptobenzothiazoles. The objectives were to investigate the substances with allergenic structures present in a diving mask giving rise to facial dermatitis, also those substances including structures from different groups of rubber chemicals. The rubber material was analysed by high-performance liquid chromatography and diode-array detector. The patient was tested by epicutaneous tests using pure substances, extracts and authentic rubber material. 2-Benzothiazolyl-N,N-diethylthiocarbamylsulfide, was found in the diving mask and the patient showed positive reaction to the pure compound and to extracts of the diving mask. This compound has structures of both mercaptobenzothiazole and thiuram/dithiocarbamate in its formulae. Besides the established groups of rubber accelerators, uncommon allergens with structures from more than one group can be formed or added at vulcanization. Chemical analysis of the product is needed to find these allergens.},
  author       = {Bergendorff, Ola and Hansson, Christer},
  issn         = {0105-1873},
  keyword      = {eczema,diethyldithiocarbamate,mercaptobenzothiazole,rubber,vulcanization},
  language     = {eng},
  number       = {5},
  pages        = {278--280},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Contact dermatitis to a rubber allergen with both dithiocarbamate and benzothiazole structure.},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2007.01076.x},
  volume       = {56},
  year         = {2007},
}