Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness
(2010) 29th Northern Ireland Biomedical Engineering Conference In Journal of Materials Science: Materials in Medicine 21(8). p.2331-2336- Abstract
- Scaffold design remains a main challenge in tissue engineering due to the large number of requirements that need to be met in order to create functional tissues in vivo. Computer simulations of tissue differentiation within scaffolds could serve as a powerful tool in elucidating the design requirements for scaffolds in tissue engineering. In this study, a lattice-based model of a 3D porous scaffold construct derived from micro CT and a mechano-biological simulation of a bone chamber experiment were combined to investigate the effect of scaffold stiffness on tissue differentiation inside the chamber. The results indicate that higher scaffold stiffness, holding pore structure constant, enhances bone formation. This study demonstrates that a... (More)
- Scaffold design remains a main challenge in tissue engineering due to the large number of requirements that need to be met in order to create functional tissues in vivo. Computer simulations of tissue differentiation within scaffolds could serve as a powerful tool in elucidating the design requirements for scaffolds in tissue engineering. In this study, a lattice-based model of a 3D porous scaffold construct derived from micro CT and a mechano-biological simulation of a bone chamber experiment were combined to investigate the effect of scaffold stiffness on tissue differentiation inside the chamber. The results indicate that higher scaffold stiffness, holding pore structure constant, enhances bone formation. This study demonstrates that a lattice approach is very suitable for modelling scaffolds in mechano-biological simulations, since it can accurately represent the micro-porous geometries of scaffolds in a 3D environment and reduce computational costs at the same time. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1675476
- author
- Khayyeri, Hanifeh LU ; Checa, Sara ; Tägil, Magnus LU ; O'Brien, Fergal J. and Prendergast, Patrick J.
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Materials Science: Materials in Medicine
- volume
- 21
- issue
- 8
- pages
- 2331 - 2336
- publisher
- Springer
- conference name
- 29th Northern Ireland Biomedical Engineering Conference
- conference dates
- 2009-04-08
- external identifiers
-
- wos:000280814800012
- scopus:79952112305
- pmid:20037774
- ISSN
- 1573-4838
- DOI
- 10.1007/s10856-009-3973-0
- language
- English
- LU publication?
- yes
- id
- eb39e68d-a9d4-48a3-8ca0-e132493aa60b (old id 1675476)
- date added to LUP
- 2016-04-01 14:12:52
- date last changed
- 2022-01-30 02:49:44
@article{eb39e68d-a9d4-48a3-8ca0-e132493aa60b, abstract = {{Scaffold design remains a main challenge in tissue engineering due to the large number of requirements that need to be met in order to create functional tissues in vivo. Computer simulations of tissue differentiation within scaffolds could serve as a powerful tool in elucidating the design requirements for scaffolds in tissue engineering. In this study, a lattice-based model of a 3D porous scaffold construct derived from micro CT and a mechano-biological simulation of a bone chamber experiment were combined to investigate the effect of scaffold stiffness on tissue differentiation inside the chamber. The results indicate that higher scaffold stiffness, holding pore structure constant, enhances bone formation. This study demonstrates that a lattice approach is very suitable for modelling scaffolds in mechano-biological simulations, since it can accurately represent the micro-porous geometries of scaffolds in a 3D environment and reduce computational costs at the same time.}}, author = {{Khayyeri, Hanifeh and Checa, Sara and Tägil, Magnus and O'Brien, Fergal J. and Prendergast, Patrick J.}}, issn = {{1573-4838}}, language = {{eng}}, number = {{8}}, pages = {{2331--2336}}, publisher = {{Springer}}, series = {{Journal of Materials Science: Materials in Medicine}}, title = {{Tissue differentiation in an in vivo bioreactor: in silico investigations of scaffold stiffness}}, url = {{http://dx.doi.org/10.1007/s10856-009-3973-0}}, doi = {{10.1007/s10856-009-3973-0}}, volume = {{21}}, year = {{2010}}, }