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Human exposure to persistent organic pollutants in West Africa - A temporal trend study from Guinea-Bissau

Linderholm, Linda; Biague, Antonio; Månsson, Fredrik LU ; Norrgren, Hans LU ; Bergman, Ake and Jakobsson, Kristina LU (2010) In Environment International 36(7). p.675-682
Abstract
Background: Humans, independent on where they live, are exposed to complex and various mixtures of chemicals, including persistent organic pollutants (POPs). The variability of the exposure depends on sources of the chemicals and is influenced by e.g. geography, social and cultural heritage. While exposures to POPs are frequently studied in populations from developed industrial countries, very little is known on levels and trends of POPs in developing countries, especially in Africa. Objectives: The aim of the present study was to investigate levels and temporal trends of POPs in adults from Guinea-Bissau. Methods: Serum samples were obtained from an open cohort of police officers in Guinea-Bissau. Repeated samples from 33 individuals were... (More)
Background: Humans, independent on where they live, are exposed to complex and various mixtures of chemicals, including persistent organic pollutants (POPs). The variability of the exposure depends on sources of the chemicals and is influenced by e.g. geography, social and cultural heritage. While exposures to POPs are frequently studied in populations from developed industrial countries, very little is known on levels and trends of POPs in developing countries, especially in Africa. Objectives: The aim of the present study was to investigate levels and temporal trends of POPs in adults from Guinea-Bissau. Methods: Serum samples were obtained from an open cohort of police officers in Guinea-Bissau. Repeated samples from 33 individuals were obtained at five time points between 1990 and 2007, in all 147 samples. Pooled serum samples were extracted and cleaned-up prior to analysis by gas chromatography and mass spectrometry. The concentration of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (4,4'-DDT) and its metabolites, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and hexachlorocyclohexanes (HCHs) were determined. Results: The major POP found in all samples was 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene (4,4'-DDE) followed by 4,4'-DDT. 4,4'-DDE, 4,4'-DDT, PCBs and beta- and gamma-HCH were significantly decreasing over time. The PBDEs were found at low concentrations, with an increasing temporal trend for BDE-153. Conclusion: National and international management may be behind the observed decreased organohalogen compound concentrations in humans from Guinea-Bissau from the early 1990's and onwards, similarly to the development of these compounds in humans from industrial countries. In contrast, PBDEs follow a trend of increasing concentrations even though at low levels. (C) 2010 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Human, HCH, PBDE, DDT, PCB, Africa
in
Environment International
volume
36
issue
7
pages
675 - 682
publisher
Elsevier
external identifiers
  • wos:000280886700004
  • scopus:77954538187
ISSN
1873-6750
DOI
10.1016/j.envint.2010.04.020
language
English
LU publication?
yes
id
5feebb8f-4c96-4715-a044-d625081eec5e (old id 1676790)
date added to LUP
2010-09-22 08:13:53
date last changed
2018-05-29 10:41:18
@article{5feebb8f-4c96-4715-a044-d625081eec5e,
  abstract     = {Background: Humans, independent on where they live, are exposed to complex and various mixtures of chemicals, including persistent organic pollutants (POPs). The variability of the exposure depends on sources of the chemicals and is influenced by e.g. geography, social and cultural heritage. While exposures to POPs are frequently studied in populations from developed industrial countries, very little is known on levels and trends of POPs in developing countries, especially in Africa. Objectives: The aim of the present study was to investigate levels and temporal trends of POPs in adults from Guinea-Bissau. Methods: Serum samples were obtained from an open cohort of police officers in Guinea-Bissau. Repeated samples from 33 individuals were obtained at five time points between 1990 and 2007, in all 147 samples. Pooled serum samples were extracted and cleaned-up prior to analysis by gas chromatography and mass spectrometry. The concentration of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (4,4'-DDT) and its metabolites, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and hexachlorocyclohexanes (HCHs) were determined. Results: The major POP found in all samples was 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene (4,4'-DDE) followed by 4,4'-DDT. 4,4'-DDE, 4,4'-DDT, PCBs and beta- and gamma-HCH were significantly decreasing over time. The PBDEs were found at low concentrations, with an increasing temporal trend for BDE-153. Conclusion: National and international management may be behind the observed decreased organohalogen compound concentrations in humans from Guinea-Bissau from the early 1990's and onwards, similarly to the development of these compounds in humans from industrial countries. In contrast, PBDEs follow a trend of increasing concentrations even though at low levels. (C) 2010 Elsevier Ltd. All rights reserved.},
  author       = {Linderholm, Linda and Biague, Antonio and Månsson, Fredrik and Norrgren, Hans and Bergman, Ake and Jakobsson, Kristina},
  issn         = {1873-6750},
  keyword      = {Human,HCH,PBDE,DDT,PCB,Africa},
  language     = {eng},
  number       = {7},
  pages        = {675--682},
  publisher    = {Elsevier},
  series       = {Environment International},
  title        = {Human exposure to persistent organic pollutants in West Africa - A temporal trend study from Guinea-Bissau},
  url          = {http://dx.doi.org/10.1016/j.envint.2010.04.020},
  volume       = {36},
  year         = {2010},
}