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Laminin isoforms in development and disease.

Schéele, Susanne LU ; Nyström, Alexander LU ; Durbeej-Hjalt, Madeleine LU ; Talts, Jan; Ekblom, Marja LU and Ekblom, Peter LU (2007) In Journal of Molecular Medicine 85(8). p.825-836
Abstract
The members of the laminin family of heterotrimers are major constituents of all basement membranes, sheet-like extracellular structures, present in almost all organs. The laminins bind to cell surface receptors and thereby tightly connect the basement membrane to the adjacent cell layer. This provides for the specific basement membrane functions to stabilize cellular structures, to serve as effective physical barriers, and furthermore, to govern cell fate by inducing intracellular signalling cascades. Many different types of diseases involve basement membranes and laminins. Metastasizing solid tumors must pass through basement membranes to reach the vascular system, and various microbes and viruses enter the cells through direct... (More)
The members of the laminin family of heterotrimers are major constituents of all basement membranes, sheet-like extracellular structures, present in almost all organs. The laminins bind to cell surface receptors and thereby tightly connect the basement membrane to the adjacent cell layer. This provides for the specific basement membrane functions to stabilize cellular structures, to serve as effective physical barriers, and furthermore, to govern cell fate by inducing intracellular signalling cascades. Many different types of diseases involve basement membranes and laminins. Metastasizing solid tumors must pass through basement membranes to reach the vascular system, and various microbes and viruses enter the cells through direct interaction with laminins. Furthermore, whereas mutations in one specific laminin chain lead to a muscular disorder, mutations of other laminin chains cause skin blistering and kidney defects, respectively. This review summarizes recent progress concerning the molecular mechanisms of laminins in development and disease. The current knowledge may lead to clinical treatment of lamininopathies and may include stem-cell approaches as well as gene therapy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lamininopathies, dystroglycan, integrin, basement membranes
in
Journal of Molecular Medicine
volume
85
issue
8
pages
825 - 836
publisher
Springer
external identifiers
  • wos:000248199500005
  • scopus:34447550067
ISSN
1432-1440
DOI
10.1007/s00109-007-0182-5
language
English
LU publication?
yes
id
e44771f1-8d35-4034-a255-2615f45ab0f4 (old id 167700)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17426950&dopt=Abstract
date added to LUP
2007-07-19 12:36:02
date last changed
2017-08-27 03:50:20
@article{e44771f1-8d35-4034-a255-2615f45ab0f4,
  abstract     = {The members of the laminin family of heterotrimers are major constituents of all basement membranes, sheet-like extracellular structures, present in almost all organs. The laminins bind to cell surface receptors and thereby tightly connect the basement membrane to the adjacent cell layer. This provides for the specific basement membrane functions to stabilize cellular structures, to serve as effective physical barriers, and furthermore, to govern cell fate by inducing intracellular signalling cascades. Many different types of diseases involve basement membranes and laminins. Metastasizing solid tumors must pass through basement membranes to reach the vascular system, and various microbes and viruses enter the cells through direct interaction with laminins. Furthermore, whereas mutations in one specific laminin chain lead to a muscular disorder, mutations of other laminin chains cause skin blistering and kidney defects, respectively. This review summarizes recent progress concerning the molecular mechanisms of laminins in development and disease. The current knowledge may lead to clinical treatment of lamininopathies and may include stem-cell approaches as well as gene therapy.},
  author       = {Schéele, Susanne and Nyström, Alexander and Durbeej-Hjalt, Madeleine and Talts, Jan and Ekblom, Marja and Ekblom, Peter},
  issn         = {1432-1440},
  keyword      = {lamininopathies,dystroglycan,integrin,basement membranes},
  language     = {eng},
  number       = {8},
  pages        = {825--836},
  publisher    = {Springer},
  series       = {Journal of Molecular Medicine},
  title        = {Laminin isoforms in development and disease.},
  url          = {http://dx.doi.org/10.1007/s00109-007-0182-5},
  volume       = {85},
  year         = {2007},
}