Triamcinolone-induced cataract in eyes with diabetic macular oedema: 3-year prospective data from a randomized clinical trial
(2010) In Clinical and Experimental Ophthalmology 38(6). p.605-612- Abstract
- P>Purpose: To describe the 3-year risk of cataract after intravitreal triamcinolone (IVTA) injections for diabetic macular oedema and the outcomes of cataract surgery. Methods: Prospective data from a randomized clinical trial were analysed. At baseline, 27 phakic eyes with diabetic macular oedema were randomized to receive IVTA and 25 to receive sham injection. After 2 years, initial sham-treated eyes were eligible to receive IVTA as the study became open label for the third year. The cumulative incidence of cataract surgery was the primary outcome of the study. Other outcomes assessed included progression of cataract, best-corrected logarithm of the minimal angle of resolution visual acuity before and after surgery and central macular... (More)
- P>Purpose: To describe the 3-year risk of cataract after intravitreal triamcinolone (IVTA) injections for diabetic macular oedema and the outcomes of cataract surgery. Methods: Prospective data from a randomized clinical trial were analysed. At baseline, 27 phakic eyes with diabetic macular oedema were randomized to receive IVTA and 25 to receive sham injection. After 2 years, initial sham-treated eyes were eligible to receive IVTA as the study became open label for the third year. The cumulative incidence of cataract surgery was the primary outcome of the study. Other outcomes assessed included progression of cataract, best-corrected logarithm of the minimal angle of resolution visual acuity before and after surgery and central macular thickness. Results: Over the 3 years of the study, 15/27 (56%) phakic eyes in the IVTA treated group underwent cataract surgery as compared with 2/25 (8%) initial sham-treated eyes (P < 0.001). Mean visual acuity 6 months after cataract surgery was better than at entry into the trial. Two (15%) of the eyes in the IVTA-treated group undergoing cataract surgery had a loss of > 15 letters. In the IVTA-treated group, 10/15 (67%) eyes that had three or more injections had progression of posterior subcapsular cataract by >= 2 grades as compared with only 2/12 (17%) eyes that had fewer than three injections (P = 0.009). Conclusions: Over half of the eyes receiving IVTA injections for diabetic macular oedema required cataract surgery within 3 years. In eyes with three or more IVTA injections, two-thirds had progression of posterior subcapsular cataract. Visual outcomes after cataract surgery were generally good, although a small proportion of eyes lost greater than 15 letters over the course of the study. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1678455
- author
- Gillies, Mark C. ; Islam, Fakir M. A. ; Larsson, Jörgen LU ; Pasadhika, Sirichi ; Gaston, Chris ; Zhu, Meidong and Wong, Tien Y.
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- visual acuity, macular oedema, cataract surgery, IVTA injection
- in
- Clinical and Experimental Ophthalmology
- volume
- 38
- issue
- 6
- pages
- 605 - 612
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000280651800012
- scopus:77955346303
- pmid:20528977
- ISSN
- 1442-6404
- DOI
- 10.1111/j.1442-9071.2010.02341.x
- language
- English
- LU publication?
- yes
- id
- c91df104-9d78-465d-a352-15adf48db5e2 (old id 1678455)
- date added to LUP
- 2016-04-01 09:56:59
- date last changed
- 2022-01-25 18:15:28
@article{c91df104-9d78-465d-a352-15adf48db5e2,
abstract = {{P>Purpose: To describe the 3-year risk of cataract after intravitreal triamcinolone (IVTA) injections for diabetic macular oedema and the outcomes of cataract surgery. Methods: Prospective data from a randomized clinical trial were analysed. At baseline, 27 phakic eyes with diabetic macular oedema were randomized to receive IVTA and 25 to receive sham injection. After 2 years, initial sham-treated eyes were eligible to receive IVTA as the study became open label for the third year. The cumulative incidence of cataract surgery was the primary outcome of the study. Other outcomes assessed included progression of cataract, best-corrected logarithm of the minimal angle of resolution visual acuity before and after surgery and central macular thickness. Results: Over the 3 years of the study, 15/27 (56%) phakic eyes in the IVTA treated group underwent cataract surgery as compared with 2/25 (8%) initial sham-treated eyes (P < 0.001). Mean visual acuity 6 months after cataract surgery was better than at entry into the trial. Two (15%) of the eyes in the IVTA-treated group undergoing cataract surgery had a loss of > 15 letters. In the IVTA-treated group, 10/15 (67%) eyes that had three or more injections had progression of posterior subcapsular cataract by >= 2 grades as compared with only 2/12 (17%) eyes that had fewer than three injections (P = 0.009). Conclusions: Over half of the eyes receiving IVTA injections for diabetic macular oedema required cataract surgery within 3 years. In eyes with three or more IVTA injections, two-thirds had progression of posterior subcapsular cataract. Visual outcomes after cataract surgery were generally good, although a small proportion of eyes lost greater than 15 letters over the course of the study.}},
author = {{Gillies, Mark C. and Islam, Fakir M. A. and Larsson, Jörgen and Pasadhika, Sirichi and Gaston, Chris and Zhu, Meidong and Wong, Tien Y.}},
issn = {{1442-6404}},
keywords = {{visual acuity; macular oedema; cataract surgery; IVTA injection}},
language = {{eng}},
number = {{6}},
pages = {{605--612}},
publisher = {{Wiley-Blackwell}},
series = {{Clinical and Experimental Ophthalmology}},
title = {{Triamcinolone-induced cataract in eyes with diabetic macular oedema: 3-year prospective data from a randomized clinical trial}},
url = {{http://dx.doi.org/10.1111/j.1442-9071.2010.02341.x}},
doi = {{10.1111/j.1442-9071.2010.02341.x}},
volume = {{38}},
year = {{2010}},
}