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Dopamine dysregulation of movement control in l-DOPA-induced dyskinesia.

Cenci Nilsson, Angela LU (2007) In Trends in Neurosciences 30(5). p.236-243
Abstract
The nigrostriatal dopamine (DA) system has an essential role in the selection and control of movement sequences, and its degeneration causes the characteristic motor symptoms of Parkinson's disease. Parkinsonian motor symptoms are alleviated by l-DOPA, but this treatment induces motor fluctuations and dyskinesias (abnormal involuntary movements). Clinical and experimental findings indicate that the motor complications of l-DOPA pharmacotherapy are triggered by transient and large changes in extracellular DA levels. The disruption of presynaptic DA homeostasis sets in motion a cascade of postsynaptic alterations, which prime the brain for a complicated motor response to dopaminomimetic treatment. l-DOPA-induced dyskinesia provides a... (More)
The nigrostriatal dopamine (DA) system has an essential role in the selection and control of movement sequences, and its degeneration causes the characteristic motor symptoms of Parkinson's disease. Parkinsonian motor symptoms are alleviated by l-DOPA, but this treatment induces motor fluctuations and dyskinesias (abnormal involuntary movements). Clinical and experimental findings indicate that the motor complications of l-DOPA pharmacotherapy are triggered by transient and large changes in extracellular DA levels. The disruption of presynaptic DA homeostasis sets in motion a cascade of postsynaptic alterations, which prime the brain for a complicated motor response to dopaminomimetic treatment. l-DOPA-induced dyskinesia provides a paradigm to study how the dysregulation of DA release and clearance results in maladaptive neuroplasticity sustaining abnormal patterns of movement. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Neurosciences
volume
30
issue
5
pages
236 - 243
publisher
Elsevier
external identifiers
  • wos:000246752000008
  • scopus:34047114733
ISSN
1878-108X
DOI
10.1016/j.tins.2007.03.005
language
English
LU publication?
yes
id
2c69d9b7-f41f-4720-9b0a-df8266563ece (old id 167866)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17400300&dopt=Abstract
date added to LUP
2007-07-11 11:12:47
date last changed
2017-11-05 04:36:57
@article{2c69d9b7-f41f-4720-9b0a-df8266563ece,
  abstract     = {The nigrostriatal dopamine (DA) system has an essential role in the selection and control of movement sequences, and its degeneration causes the characteristic motor symptoms of Parkinson's disease. Parkinsonian motor symptoms are alleviated by l-DOPA, but this treatment induces motor fluctuations and dyskinesias (abnormal involuntary movements). Clinical and experimental findings indicate that the motor complications of l-DOPA pharmacotherapy are triggered by transient and large changes in extracellular DA levels. The disruption of presynaptic DA homeostasis sets in motion a cascade of postsynaptic alterations, which prime the brain for a complicated motor response to dopaminomimetic treatment. l-DOPA-induced dyskinesia provides a paradigm to study how the dysregulation of DA release and clearance results in maladaptive neuroplasticity sustaining abnormal patterns of movement.},
  author       = {Cenci Nilsson, Angela},
  issn         = {1878-108X},
  language     = {eng},
  number       = {5},
  pages        = {236--243},
  publisher    = {Elsevier},
  series       = {Trends in Neurosciences},
  title        = {Dopamine dysregulation of movement control in l-DOPA-induced dyskinesia.},
  url          = {http://dx.doi.org/10.1016/j.tins.2007.03.005},
  volume       = {30},
  year         = {2007},
}