A mass spectrometry-based strategy for the direct detection and quantification of some mycotoxins produced by Stachybotrys and Aspergillus in indoor environments.
(2007) In Applied and Environmental Microbiology 73(13). p.4211-4217- Abstract
- Dampness in buildings has been linked to adverse health effects, but the specific causative agents are unknown. Mycotoxins are secondary metabolites produced by molds and toxic to higher vertebrates. In this study, mass spectrometry was used to demonstrate the presence of mycotoxins predominantly produced by Aspergillus spp. and Stachybotrys spp. in buildings with either ongoing dampness or a history of water damage. Verrucarol and trichodermol, hydrolysis products of macrocyclic trichothecenes (including satratoxins), and trichodermin, predominately produced by Stachybotrys chartarum, were analyzed by gas chromatographytandem mass spectrometry, whereas sterigmatocystin (mainly produced by Aspergillus versicolor), satratoxin G, and... (More)
- Dampness in buildings has been linked to adverse health effects, but the specific causative agents are unknown. Mycotoxins are secondary metabolites produced by molds and toxic to higher vertebrates. In this study, mass spectrometry was used to demonstrate the presence of mycotoxins predominantly produced by Aspergillus spp. and Stachybotrys spp. in buildings with either ongoing dampness or a history of water damage. Verrucarol and trichodermol, hydrolysis products of macrocyclic trichothecenes (including satratoxins), and trichodermin, predominately produced by Stachybotrys chartarum, were analyzed by gas chromatographytandem mass spectrometry, whereas sterigmatocystin (mainly produced by Aspergillus versicolor), satratoxin G, and satratoxin H were analyzed by high-performance liquid chromatography-tandem mass spectrometry. These mycotoxin analytes were demonstrated in 45 of 62 building material samples studied, in three of eight settled dust samples, and in five of eight cultures of airborne dust samples. This is the first report on the use of tandem mass spectrometry for demonstrating mycotoxins in dust settled on surfaces above floor level in damp buildings. The direct detection of the highly toxic sterigmatocystin and macrocyclic trichothecene mycotoxins in indoor environments is important due to their potential health impacts. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/168398
- author
- Bloom, Erica LU ; Bal, Karol LU ; Nyman, Eva ; Must, Aime and Larsson, Lennart LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Applied and Environmental Microbiology
- volume
- 73
- issue
- 13
- pages
- 4211 - 4217
- publisher
- American Society for Microbiology
- external identifiers
-
- wos:000248070000016
- scopus:34447558683
- pmid:17483261
- ISSN
- 0099-2240
- DOI
- 10.1128/AEM.00343-07
- language
- English
- LU publication?
- yes
- id
- 44ca7952-52b4-4040-8d43-758d26ed5385 (old id 168398)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17483261&dopt=Abstract
- date added to LUP
- 2016-04-01 12:04:17
- date last changed
- 2022-04-21 01:58:24
@article{44ca7952-52b4-4040-8d43-758d26ed5385,
abstract = {{Dampness in buildings has been linked to adverse health effects, but the specific causative agents are unknown. Mycotoxins are secondary metabolites produced by molds and toxic to higher vertebrates. In this study, mass spectrometry was used to demonstrate the presence of mycotoxins predominantly produced by Aspergillus spp. and Stachybotrys spp. in buildings with either ongoing dampness or a history of water damage. Verrucarol and trichodermol, hydrolysis products of macrocyclic trichothecenes (including satratoxins), and trichodermin, predominately produced by Stachybotrys chartarum, were analyzed by gas chromatographytandem mass spectrometry, whereas sterigmatocystin (mainly produced by Aspergillus versicolor), satratoxin G, and satratoxin H were analyzed by high-performance liquid chromatography-tandem mass spectrometry. These mycotoxin analytes were demonstrated in 45 of 62 building material samples studied, in three of eight settled dust samples, and in five of eight cultures of airborne dust samples. This is the first report on the use of tandem mass spectrometry for demonstrating mycotoxins in dust settled on surfaces above floor level in damp buildings. The direct detection of the highly toxic sterigmatocystin and macrocyclic trichothecene mycotoxins in indoor environments is important due to their potential health impacts.}},
author = {{Bloom, Erica and Bal, Karol and Nyman, Eva and Must, Aime and Larsson, Lennart}},
issn = {{0099-2240}},
language = {{eng}},
number = {{13}},
pages = {{4211--4217}},
publisher = {{American Society for Microbiology}},
series = {{Applied and Environmental Microbiology}},
title = {{A mass spectrometry-based strategy for the direct detection and quantification of some mycotoxins produced by Stachybotrys and Aspergillus in indoor environments.}},
url = {{http://dx.doi.org/10.1128/AEM.00343-07}},
doi = {{10.1128/AEM.00343-07}},
volume = {{73}},
year = {{2007}},
}