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Long term hearing degeneration after platinum-based chemotherapy in childhood.

Einarsson, Einar-Jon LU ; Petersen, Hannes ; Wiebe, Thomas LU ; Fransson, Per-Anders LU orcid ; Grenner, Jan LU ; Magnusson, Mås and Moëll, Christer (2010) In International Journal of Audiology 49(10). p.765-771
Abstract
The aim of this study was to investigate long-term development of hearing in subjects who had received platinum-based chemotherapy in childhood or adolescence. Another aim was to assess the self-reported hearing loss handicap and compare it to audiometric measurements. Medical records from individuals diagnosed with childhood cancer and treated with platinum-based chemotherapy between 1985 and 2000 at the University Hospital in Lund Sweden were reviewed retrospectively. Fifteen subjects, who fulfilled the eligibility criteria set for the study, underwent a thorough audiometric evaluation. The results show that the hearing loss, in subjects with ototoxicity had increased after the end of treatment, to include also the lower frequencies. The... (More)
The aim of this study was to investigate long-term development of hearing in subjects who had received platinum-based chemotherapy in childhood or adolescence. Another aim was to assess the self-reported hearing loss handicap and compare it to audiometric measurements. Medical records from individuals diagnosed with childhood cancer and treated with platinum-based chemotherapy between 1985 and 2000 at the University Hospital in Lund Sweden were reviewed retrospectively. Fifteen subjects, who fulfilled the eligibility criteria set for the study, underwent a thorough audiometric evaluation. The results show that the hearing loss, in subjects with ototoxicity had increased after the end of treatment, to include also the lower frequencies. The largest deterioration in hearing thresholds, up to 55 dB HL, was found at frequencies above 2 kHz. The findings also reveal that the subjects have a considerably greater hearing loss handicap and disability than would be expected from the results of the audiometric evaluations. The conclusion of this study is that children and adolescence treated with platinum-based chemotherapy should have regular audiometric follow-up examinations, also many years after the end of treatment. Furthermore, assessments of self-reported hearing disability should be made during and after chemotherapy. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Audiology
volume
49
issue
10
pages
765 - 771
publisher
Taylor & Francis
external identifiers
  • wos:000282817200006
  • pmid:20874050
  • scopus:77957596283
  • pmid:20874050
ISSN
1708-8186
DOI
10.3109/14992027.2010.485595
language
English
LU publication?
yes
id
9e543806-7bfb-4efc-b60c-b193786bdbaa (old id 1687754)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20874050?dopt=Abstract
date added to LUP
2016-04-04 08:16:30
date last changed
2024-01-12 04:23:53
@article{9e543806-7bfb-4efc-b60c-b193786bdbaa,
  abstract     = {{The aim of this study was to investigate long-term development of hearing in subjects who had received platinum-based chemotherapy in childhood or adolescence. Another aim was to assess the self-reported hearing loss handicap and compare it to audiometric measurements. Medical records from individuals diagnosed with childhood cancer and treated with platinum-based chemotherapy between 1985 and 2000 at the University Hospital in Lund Sweden were reviewed retrospectively. Fifteen subjects, who fulfilled the eligibility criteria set for the study, underwent a thorough audiometric evaluation. The results show that the hearing loss, in subjects with ototoxicity had increased after the end of treatment, to include also the lower frequencies. The largest deterioration in hearing thresholds, up to 55 dB HL, was found at frequencies above 2 kHz. The findings also reveal that the subjects have a considerably greater hearing loss handicap and disability than would be expected from the results of the audiometric evaluations. The conclusion of this study is that children and adolescence treated with platinum-based chemotherapy should have regular audiometric follow-up examinations, also many years after the end of treatment. Furthermore, assessments of self-reported hearing disability should be made during and after chemotherapy.}},
  author       = {{Einarsson, Einar-Jon and Petersen, Hannes and Wiebe, Thomas and Fransson, Per-Anders and Grenner, Jan and Magnusson, Mås and Moëll, Christer}},
  issn         = {{1708-8186}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{765--771}},
  publisher    = {{Taylor & Francis}},
  series       = {{International Journal of Audiology}},
  title        = {{Long term hearing degeneration after platinum-based chemotherapy in childhood.}},
  url          = {{http://dx.doi.org/10.3109/14992027.2010.485595}},
  doi          = {{10.3109/14992027.2010.485595}},
  volume       = {{49}},
  year         = {{2010}},
}