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Cerebellar molecular layer interneurons - computational properties and roles in learning.

Jörntell, Henrik LU ; Bengtsson, Fredrik LU ; Schonewille, Martijn and De Zeeuw, Chris I (2010) In Trends in Neurosciences 33. p.524-532
Abstract
In recent years there has been an increased interest in the function of inhibitory interneurons. In the cerebellum this interest has been paired with successes in obtaining recordings from these neurons in vivo and genetic manipulations to probe their function during behavioral tasks such as motor learning. This review focuses on a synthesis of recent findings on the computational properties that these neurons confer to the cerebellar circuitry and on their recently discovered capacity for plasticity and learning in vivo. Since the circuitry of the cerebellar cortex is relatively well-defined, the specificity with which the potential roles of these interneurons can be described will help to guide new avenues of research on the functions of... (More)
In recent years there has been an increased interest in the function of inhibitory interneurons. In the cerebellum this interest has been paired with successes in obtaining recordings from these neurons in vivo and genetic manipulations to probe their function during behavioral tasks such as motor learning. This review focuses on a synthesis of recent findings on the computational properties that these neurons confer to the cerebellar circuitry and on their recently discovered capacity for plasticity and learning in vivo. Since the circuitry of the cerebellar cortex is relatively well-defined, the specificity with which the potential roles of these interneurons can be described will help to guide new avenues of research on the functions of interneurons in general. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Neurosciences
volume
33
pages
524 - 532
publisher
Elsevier
external identifiers
  • wos:000284493700005
  • pmid:20869126
  • scopus:77958155395
ISSN
1878-108X
DOI
10.1016/j.tins.2010.08.004
language
English
LU publication?
yes
id
a85bb391-3b7d-4d6c-ba2e-f7726e3ada73 (old id 1687814)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20869126?dopt=Abstract
date added to LUP
2010-10-07 15:40:41
date last changed
2017-07-30 04:54:07
@article{a85bb391-3b7d-4d6c-ba2e-f7726e3ada73,
  abstract     = {In recent years there has been an increased interest in the function of inhibitory interneurons. In the cerebellum this interest has been paired with successes in obtaining recordings from these neurons in vivo and genetic manipulations to probe their function during behavioral tasks such as motor learning. This review focuses on a synthesis of recent findings on the computational properties that these neurons confer to the cerebellar circuitry and on their recently discovered capacity for plasticity and learning in vivo. Since the circuitry of the cerebellar cortex is relatively well-defined, the specificity with which the potential roles of these interneurons can be described will help to guide new avenues of research on the functions of interneurons in general.},
  author       = {Jörntell, Henrik and Bengtsson, Fredrik and Schonewille, Martijn and De Zeeuw, Chris I},
  issn         = {1878-108X},
  language     = {eng},
  pages        = {524--532},
  publisher    = {Elsevier},
  series       = {Trends in Neurosciences},
  title        = {Cerebellar molecular layer interneurons - computational properties and roles in learning.},
  url          = {http://dx.doi.org/10.1016/j.tins.2010.08.004},
  volume       = {33},
  year         = {2010},
}