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Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury?

Albinsson, Sebastian LU and Sessa, William C (2010) In Physiological Genomics okt.
Abstract
Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in vascular proliferative diseases. Recent studies have established micro-RNAs (miRNAs) as important mediators for the modulation of VSMC phenotype by targeting transcription factors and the cytoskeleton, which act as molecular switches for VSMC differentiation. The importance of miRNAs for VSMC development, differentiation and function is evident by the fact that loss of the miRNA processing enzyme Dicer in VSMCs results in embryonic lethality due to severe vascular abnormalities. In addition, a role of specific miRNAs for neointimal hyperplasia following vascular injury has been reported which provides interesting possibilities for future therapeutical... (More)
Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in vascular proliferative diseases. Recent studies have established micro-RNAs (miRNAs) as important mediators for the modulation of VSMC phenotype by targeting transcription factors and the cytoskeleton, which act as molecular switches for VSMC differentiation. The importance of miRNAs for VSMC development, differentiation and function is evident by the fact that loss of the miRNA processing enzyme Dicer in VSMCs results in embryonic lethality due to severe vascular abnormalities. In addition, a role of specific miRNAs for neointimal hyperplasia following vascular injury has been reported which provides interesting possibilities for future therapeutical targets against vascular disease. Herein, we summarize recent advances regarding the role of miRNAs in VSMC phenotype modulation and response to injury. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physiological Genomics
volume
okt
publisher
American Physiological Society
external identifiers
  • pmid:20841497
  • scopus:79957655520
ISSN
1094-8341
DOI
10.1152/physiolgenomics.00146.2010
language
English
LU publication?
yes
id
ab65b8d8-466d-4037-b609-b59f22f4dedb (old id 1688259)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20841497?dopt=Abstract
date added to LUP
2010-10-05 09:47:26
date last changed
2018-06-24 04:48:23
@article{ab65b8d8-466d-4037-b609-b59f22f4dedb,
  abstract     = {Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in vascular proliferative diseases. Recent studies have established micro-RNAs (miRNAs) as important mediators for the modulation of VSMC phenotype by targeting transcription factors and the cytoskeleton, which act as molecular switches for VSMC differentiation. The importance of miRNAs for VSMC development, differentiation and function is evident by the fact that loss of the miRNA processing enzyme Dicer in VSMCs results in embryonic lethality due to severe vascular abnormalities. In addition, a role of specific miRNAs for neointimal hyperplasia following vascular injury has been reported which provides interesting possibilities for future therapeutical targets against vascular disease. Herein, we summarize recent advances regarding the role of miRNAs in VSMC phenotype modulation and response to injury.},
  author       = {Albinsson, Sebastian and Sessa, William C},
  issn         = {1094-8341},
  language     = {eng},
  publisher    = {American Physiological Society},
  series       = {Physiological Genomics},
  title        = {Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury?},
  url          = {http://dx.doi.org/10.1152/physiolgenomics.00146.2010},
  volume       = {okt},
  year         = {2010},
}