Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury?
(2010) In Physiological Genomics okt.- Abstract
- Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in vascular proliferative diseases. Recent studies have established micro-RNAs (miRNAs) as important mediators for the modulation of VSMC phenotype by targeting transcription factors and the cytoskeleton, which act as molecular switches for VSMC differentiation. The importance of miRNAs for VSMC development, differentiation and function is evident by the fact that loss of the miRNA processing enzyme Dicer in VSMCs results in embryonic lethality due to severe vascular abnormalities. In addition, a role of specific miRNAs for neointimal hyperplasia following vascular injury has been reported which provides interesting possibilities for future therapeutical... (More)
- Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in vascular proliferative diseases. Recent studies have established micro-RNAs (miRNAs) as important mediators for the modulation of VSMC phenotype by targeting transcription factors and the cytoskeleton, which act as molecular switches for VSMC differentiation. The importance of miRNAs for VSMC development, differentiation and function is evident by the fact that loss of the miRNA processing enzyme Dicer in VSMCs results in embryonic lethality due to severe vascular abnormalities. In addition, a role of specific miRNAs for neointimal hyperplasia following vascular injury has been reported which provides interesting possibilities for future therapeutical targets against vascular disease. Herein, we summarize recent advances regarding the role of miRNAs in VSMC phenotype modulation and response to injury. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1688259
- author
- Albinsson, Sebastian LU and Sessa, William C
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physiological Genomics
- volume
- okt
- publisher
- American Physiological Society
- external identifiers
-
- pmid:20841497
- scopus:79957655520
- pmid:20841497
- ISSN
- 1094-8341
- DOI
- 10.1152/physiolgenomics.00146.2010
- language
- English
- LU publication?
- yes
- id
- ab65b8d8-466d-4037-b609-b59f22f4dedb (old id 1688259)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20841497?dopt=Abstract
- date added to LUP
- 2016-04-04 08:47:18
- date last changed
- 2022-01-29 03:59:07
@article{ab65b8d8-466d-4037-b609-b59f22f4dedb,
abstract = {{Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in vascular proliferative diseases. Recent studies have established micro-RNAs (miRNAs) as important mediators for the modulation of VSMC phenotype by targeting transcription factors and the cytoskeleton, which act as molecular switches for VSMC differentiation. The importance of miRNAs for VSMC development, differentiation and function is evident by the fact that loss of the miRNA processing enzyme Dicer in VSMCs results in embryonic lethality due to severe vascular abnormalities. In addition, a role of specific miRNAs for neointimal hyperplasia following vascular injury has been reported which provides interesting possibilities for future therapeutical targets against vascular disease. Herein, we summarize recent advances regarding the role of miRNAs in VSMC phenotype modulation and response to injury.}},
author = {{Albinsson, Sebastian and Sessa, William C}},
issn = {{1094-8341}},
language = {{eng}},
publisher = {{American Physiological Society}},
series = {{Physiological Genomics}},
title = {{Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury?}},
url = {{http://dx.doi.org/10.1152/physiolgenomics.00146.2010}},
doi = {{10.1152/physiolgenomics.00146.2010}},
volume = {{okt}},
year = {{2010}},
}