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Experimental Models for the Study of Female and Male Sexual Function

Giuliano, Francois; Pfaus, James; Balasubramanian, Srilatha; Hedlund, Petter LU ; Hisasue, Shin-ichi; Marson, Lesley and Wallen, Kim (2010) In Journal of Sexual Medicine 7(9). p.2970-2995
Abstract
Introduction. Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models. Aim. To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation. Methods. Consensus discussion over the past 18 months leading to summarized views of seven experts from six countries. Main Outcome Measure. Report was based on the critical analysis of scientific information available in literature and subcommittee presentations, discussions, and exchanges of ideas and feedback. Results. Fundamental research in animal models has led to considerable understanding of... (More)
Introduction. Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models. Aim. To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation. Methods. Consensus discussion over the past 18 months leading to summarized views of seven experts from six countries. Main Outcome Measure. Report was based on the critical analysis of scientific information available in literature and subcommittee presentations, discussions, and exchanges of ideas and feedback. Results. Fundamental research in animal models has led to considerable understanding of the physiological mechanisms underlying desire, arousal, genital, and other sexual responses and the design of rational pharmacological treatments for certain sexual dysfunctions in the male and female. Tissue and cellular in vitro systems have provided critical information on the in vivo interactions and modulations in the presence and absence of chemical, biological, vascular, neurologic, endocrine, and genetic inputs. The animal models seem indispensable for elucidating the biophysiological and etiopathological aspects of male and female sexual disorders. Conclusions. Useful insights into the human experience have been derived from basic research in ways that are far more difficult to obtain in humans, both scientifically and ethically. The animal model with a good predictive value can be used as a successful preclinical tool so long as the functional end points are homologous or analogous. The key issue is whether further evaluations are warranted to extrapolate the results in a clinical setting. Giuliano F, Pfaus J, Balasubramanian S, Hedlund P, Hisasue S, Marson L, and Wallen K. Experimental models for the study of female and male sexual function. J Sex Med 2010;7:2970-2995. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Studies, Behavioral, Female Sexual Function, Animal Models, Male Sexual Function, In Vitro Studies, In Vivo Studies
in
Journal of Sexual Medicine
volume
7
issue
9
pages
2970 - 2995
publisher
Wiley-Blackwell
external identifiers
  • wos:000281550700006
  • scopus:77956295224
ISSN
1743-6109
DOI
10.1111/j.1743-6109.2010.01960.x
language
English
LU publication?
yes
id
339fc12a-2ad8-494c-8853-b71fa96ee14b (old id 1697680)
date added to LUP
2010-10-22 16:23:16
date last changed
2018-05-29 09:50:27
@article{339fc12a-2ad8-494c-8853-b71fa96ee14b,
  abstract     = {Introduction. Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models. Aim. To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation. Methods. Consensus discussion over the past 18 months leading to summarized views of seven experts from six countries. Main Outcome Measure. Report was based on the critical analysis of scientific information available in literature and subcommittee presentations, discussions, and exchanges of ideas and feedback. Results. Fundamental research in animal models has led to considerable understanding of the physiological mechanisms underlying desire, arousal, genital, and other sexual responses and the design of rational pharmacological treatments for certain sexual dysfunctions in the male and female. Tissue and cellular in vitro systems have provided critical information on the in vivo interactions and modulations in the presence and absence of chemical, biological, vascular, neurologic, endocrine, and genetic inputs. The animal models seem indispensable for elucidating the biophysiological and etiopathological aspects of male and female sexual disorders. Conclusions. Useful insights into the human experience have been derived from basic research in ways that are far more difficult to obtain in humans, both scientifically and ethically. The animal model with a good predictive value can be used as a successful preclinical tool so long as the functional end points are homologous or analogous. The key issue is whether further evaluations are warranted to extrapolate the results in a clinical setting. Giuliano F, Pfaus J, Balasubramanian S, Hedlund P, Hisasue S, Marson L, and Wallen K. Experimental models for the study of female and male sexual function. J Sex Med 2010;7:2970-2995.},
  author       = {Giuliano, Francois and Pfaus, James and Balasubramanian, Srilatha and Hedlund, Petter and Hisasue, Shin-ichi and Marson, Lesley and Wallen, Kim},
  issn         = {1743-6109},
  keyword      = {Studies,Behavioral,Female Sexual Function,Animal Models,Male Sexual Function,In Vitro Studies,In Vivo Studies},
  language     = {eng},
  number       = {9},
  pages        = {2970--2995},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Sexual Medicine},
  title        = {Experimental Models for the Study of Female and Male Sexual Function},
  url          = {http://dx.doi.org/10.1111/j.1743-6109.2010.01960.x},
  volume       = {7},
  year         = {2010},
}